All Outputs (11)

Outcome assessment in dermatology clinical trials and cochrane reviews: call for a dermatology‐specific outcome taxonomy (2020)
Journal Article
Lange, T., Kottner, J., Weberschock, T., Hahnel, E., Apfelbacher, C., Brandstetter, S., …Schmitt, J. (2021). Outcome assessment in dermatology clinical trials and cochrane reviews: call for a dermatology‐specific outcome taxonomy. Journal of the European Academy of Dermatology and Venereology, 35(2), 523-535. https://doi.org/10.1111/jdv.16854

Background: Standardized outcome reporting is crucial for trial evidence synthesis and translation of findings into clinical decision making. The OMERACT 2.0 Filter and COMET outcome domain taxonomy propose frameworks for consistent reporting of outc... Read More about Outcome assessment in dermatology clinical trials and cochrane reviews: call for a dermatology‐specific outcome taxonomy.

Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable (2018)
Journal Article
Schmitt, J., Lange, T., Kottner, J., Prinsen, C. A. C., Weberschock, T., Hahnel, E., …Cochrane Skin Core Outcome Set Initiative (CS-COUSIN). (2019). Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable. Journal of Investigative Dermatology, 139(5), 1045-1053. https://doi.org/10.1016/j.jid.2018.11.019

Evidence-based healthcare requires that relevant outcomes for patients are included in clinical trials which investigating treatment effects allowing subsequent systematic reviews to summarize all relevant evidence to guide clinical practice. Current... Read More about Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable.

What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 2: prevention and treatment (2018)
Journal Article
Lloyd-Lavery, A., Rogers, N. K., Davies, E., Grindlay, D. J. C., & Thomas, K. S. (2018). What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 2: prevention and treatment. Clinical and Experimental Dermatology, 43(6), 653-658. https://doi.org/10.1111/ced.13554

This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 26 systematic reviews that were published... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 2: prevention and treatment.

What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology (2018)
Journal Article
Davies, E., Rogers, N. K., Lloyd-Lavery, A., Grindlay, D. J. C., & Thomas, K. S. (2018). What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology. Clinical and Experimental Dermatology, 43(4), 375-379. https://doi.org/10.1111/ced.13377

This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 15 systematic reviews that were published... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology.

What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 2. Treatment and prevention (2016)
Journal Article
Lloyd-Lavery, A., Rogers, N. K., Hatfield, S. J., Grindlay, D., Barnett, R., & Thomas, K. S. (2017). What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 2. Treatment and prevention. Clinical and Experimental Dermatology, 42(1), 3-7. https://doi.org/10.1111/ced.12967

This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE). It provides a summary of key findings from 12 systematic reviews (SRs) that were published or indexed during 2014, and focuses on the treatm... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 2. Treatment and prevention.

What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 1. Epidemiology, risk factors and outcomes (2016)
Journal Article
Hatfield, S. J., Rogers, N. K., Lloyd-Lavery, A., Grindlay, D., Barnett, R., & Thomas, K. S. (2016). What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 1. Epidemiology, risk factors and outcomes. Clinical and Experimental Dermatology, 41(8), 843-846. https://doi.org/10.1111/ced.12977

This review summarizes key findings from nine systematic reviews on atopic eczema (AE) published or first indexed in 2014. It focuses on epidemiology, disease processes and methodological issues. There is reasonable evidence to conclude that high bir... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 1. Epidemiology, risk factors and outcomes.

What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials (2016)
Journal Article
Nankervis, H., Thomas, K., Delamere, F. M., Barbarot, S., Smith, S., Rogers, N. K., & Williams, H. C. (in press). What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials. British Journal of Dermatology, 176(4), https://doi.org/10.1111/bjd.14999

Atopic eczema (AE) is a common chronic inflammatory skin condition. Whilst many AE treatment options are available, the evidence to support their efficacy varies in depth and quality. In 2000, an NIHR HTA systematic review identified and evaluated ex... Read More about What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials.

Strategies used for measuring long-term control in atopic dermatitis trials: A systematic review (2016)
Journal Article
Barbarot, S., Rogers, N. K., Abuabara, K., Aubert, H., Chalmers, J., Flohr, C., …Thomas, K. S. (2016). Strategies used for measuring long-term control in atopic dermatitis trials: A systematic review. Journal of The American Academy of Dermatology, 75(5), https://doi.org/10.1016/j.jaad.2016.05.043

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. There are no standardised methods for capturing long-term control of AD. Objective: To identify how long-term control has been captured in published randomised controlled t... Read More about Strategies used for measuring long-term control in atopic dermatitis trials: A systematic review.

Scoping systematic review of treatments for eczema (2016)
Journal Article
Nankervis, H., Thomas, K., Delamere, F. M., Barbarot, S., Rogers, N. K., & Williams, H. C. (2016). Scoping systematic review of treatments for eczema. Programme Grants for Applied Research, 4(7), https://doi.org/10.3310/pgfar04070

Background: Eczema is a very common chronic inflammatory skin condition. Objectives: To update the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) systematic review of treatments for atopic eczema, published in 2000,... Read More about Scoping systematic review of treatments for eczema.

Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma (2014)
Journal Article
Rogers, N. K., Clements, D., Dongre, A., Harrison, T. W., Shaw, D. E., & Johnson, S. R. (2014). Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma. PLoS ONE, 9(2), Article e90565. https://doi.org/10.1371/journal.pone.0090565

Airway remodelling describes the histopathological changes leading to fixed airway obstruction in patients with asthma and includes extra-cellular matrix (ECM) deposition. Matrix metalloproteinase-1 (MMP-1) is present in remodelled airways but its re... Read More about Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma.

Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration (2010)
Journal Article
Rogers, N., Paine, S., Bedford, L., & Layfield, R. (2010). Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration. Neuropathology and Applied Neurobiology, 36(2), 113-124. https://doi.org/10.1111/j.1365-2990.2010.01063.x

The significance of the accumulation of ubiquitin-positive intraneuronal inclusions in the brains of those affected with different neurodegenerative diseases is currently unclear. While one interpretation is that the disease mechanism(s) involves dys... Read More about Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration.