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All Outputs (10)

Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences (2024)
Preprint / Working Paper
Deakin, B., Liddle, E., Rathnaiah, M., Gregory, C., Katshu, M., Wiliams, G., Conen, S., Smallman, R., Koelewijn, L. C., Anton, A., Kumar, J., Gasgoyne, L. E., Chen, C., Nikkheslat, N., Evans, J., Lanz, B., Walters, J., Talbot, P., Palaniyappan, L., Singh, K. D., …Liddle, P. F. Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences

It is widely thought that the onset of psychotic symptoms in schizophrenia may arise from an early neurotoxic phase, possibly related to oxidative stress or inflammation, and a late residual damage phase associated with persistent negative symptoms.... Read More about Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences.

Implementing and Evaluating a National Integrated Digital Registry and Clinical Decision Support System in Early Intervention in Psychosis Services (Early Psychosis Informatics Into Care): Co-Designed Protocol (2024)
Journal Article
Griffiths, S. L., Murray, G. K., Logeswaran, Y., Ainsworth, J., Allan, S. M., Campbell, N., …Upthegrove, R. (2024). Implementing and Evaluating a National Integrated Digital Registry and Clinical Decision Support System in Early Intervention in Psychosis Services (Early Psychosis Informatics Into Care): Co-Designed Protocol. JMIR Research Protocols, 13(1), Article e50177. https://doi.org/10.2196/50177

Background: Early intervention in psychosis (EIP) services are nationally mandated in England to provide multidisciplinary care to people experiencing first-episode psychosis, which disproportionately affects deprived and ethnic minority youth. Quali... Read More about Implementing and Evaluating a National Integrated Digital Registry and Clinical Decision Support System in Early Intervention in Psychosis Services (Early Psychosis Informatics Into Care): Co-Designed Protocol.

Second-generation antipsychotics and metabolic syndrome: a role for mitochondria (2023)
Journal Article
Mortimer, K. R. H., Katshu, M. Z. U. H., & Chakrabarti, L. (2023). Second-generation antipsychotics and metabolic syndrome: a role for mitochondria. Frontiers in Psychiatry, 14, Article 1257460. https://doi.org/10.3389/fpsyt.2023.1257460

Psychosis is a known risk factor for developing metabolic syndrome (MetS). The risk is even greater in patients who are taking second-generation antipsychotics (SGAs). SGAs exacerbate metabolic abnormalities and lead to a 3-fold increased risk of sev... Read More about Second-generation antipsychotics and metabolic syndrome: a role for mitochondria.

Measurement of brain glutathione with magnetic Resonance spectroscopy in Schizophrenia-Spectrum disorders - A systematic review and Meta-Analysis. (2023)
Journal Article
Murray, A. J., Humpston, C. S., Wilson, M., Rogers, J. C., Zia Ul Haq Katshu, M., Liddle, P. F., & Upthegrove, R. (2024). Measurement of brain glutathione with magnetic Resonance spectroscopy in Schizophrenia-Spectrum disorders - A systematic review and Meta-Analysis. Brain, Behavior, and Immunity, 115, 3-12. https://doi.org/10.1016/j.bbi.2023.09.017

Oxidative stress may contribute to declining course and poor outcomes in psychosis. However, in vivo Magnetic Resonance Spectroscopy studies yield disparate results due to clinical stage, sample demographics, neuroanatomical focus, sample size, and a... Read More about Measurement of brain glutathione with magnetic Resonance spectroscopy in Schizophrenia-Spectrum disorders - A systematic review and Meta-Analysis..

The chronic neuropsychiatric sequelae of COVID-19: The need for a prospective study of viral impact on brain functioning (2021)
Journal Article
Erausquin, G. A., Snyder, H., Carrillo, M., Hosseini, A. A., Brugha, T. S., Seshadri, S., & the CNS SARS‐CoV‐2 Consortium. (2021). The chronic neuropsychiatric sequelae of COVID-19: The need for a prospective study of viral impact on brain functioning. Alzheimer's and Dementia, 17(6), 1056-1065. https://doi.org/10.1002/alz.12255

Introduction: The increasing evidence of SARS-CoV-2 impact on the central nervous system (CNS) raises key questions on its impact for risk of later life cognitive decline, Alzheimer's disease (AD), and other dementia. Methods: The Alzheimer's Associa... Read More about The chronic neuropsychiatric sequelae of COVID-19: The need for a prospective study of viral impact on brain functioning.

Impaired recollection-based episodic memory as a cognitive endophenotype in schizophrenia (2020)
Journal Article
Abhishek, P., Nizamie, S. H., Jahan, M., Kumar, D., Goyal, N., Pachori, H., & Katshu, M. Z. U. H. (2020). Impaired recollection-based episodic memory as a cognitive endophenotype in schizophrenia. Journal of Clinical and Experimental Neuropsychology, 42(8), 759-770. https://doi.org/10.1080/13803395.2020.1801598

Introduction
Patients with schizophrenia show impaired recollection but largely preserved familiarity-based episodic memory. This study was done to clarify the endophenotypic nature of recollection and familiarity-based episodic memory in schizophre... Read More about Impaired recollection-based episodic memory as a cognitive endophenotype in schizophrenia.

Glutathione and glutamate in schizophrenia: a 7T MRS study (2018)
Journal Article
Kumar, J., Liddle, E. B., Fernandes, C. C., Palaniyappan, L., Hall, E. L., Robson, S. E., Simmonite, M., Fiesal, J., Katshu, M. Z., Qureshi, A., Skelton, M., Christodoulou, N. G., Brookes, M. J., Morris, P. G., & Liddle, P. F. (2018). Glutathione and glutamate in schizophrenia: a 7T MRS study. Molecular Psychiatry, 25(4), 873–882. https://doi.org/10.1038/s41380-018-0104-7

© 2018 The Author(s) In schizophrenia, abnormal neural metabolite concentrations may arise from cortical damage following neuroinflammatory processes implicated in acute episodes. Inflammation is associated with increased glutamate, whereas the antio... Read More about Glutathione and glutamate in schizophrenia: a 7T MRS study.

Evaluation of spontaneous dense array gamma oscillatory activity and minor physical anomalies as a composite neurodevelopmental endophenotype in schizophrenia (2014)
Journal Article
Tikka, S. K., Nizamie, S. H., Goyal, N., Pradhan, N., Tikka, D. L., & Katshu, M. Z. U. H. (2015). Evaluation of spontaneous dense array gamma oscillatory activity and minor physical anomalies as a composite neurodevelopmental endophenotype in schizophrenia. International Journal of Developmental Neuroscience, 40(1), 43-51. https://doi.org/10.1016/j.ijdevneu.2014.11.002