AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development

Bitoun, E.; Finelli, M. J.; Oliver, P. L.; Lee, S.; Davies, K. E.

doi:10.1523/jneurosci.5188-09.2009

All Outputs (24)

Differential Phosphorylation of Smad1 Integrates BMP and Neurotrophin Pathways through Erk/Dusp in Axon Development (2013)
Journal Article
Finelli, M., Murphy, K., Chen, L., & Zou, H. (2013). Differential Phosphorylation of Smad1 Integrates BMP and Neurotrophin Pathways through Erk/Dusp in Axon Development. Cell Reports, 3(5), 1592-1606. https://doi.org/10.1016/j.celrep.2013.04.011

Sensory axon development requires concerted actions of growth factors for the precise control of axonal outgrowth and target innervation. How developing sensory neurons integrate different cues is poorly understood. We demonstrate here that Smad1 act... Read More about Differential Phosphorylation of Smad1 Integrates BMP and Neurotrophin Pathways through Erk/Dusp in Axon Development.

The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy (2013)
Journal Article
Carroll, B., Mohd-Naim, N., Maximiano, F., Frasa, M., McCormack, J., Finelli, M., Thoresen, S., Perdios, L., Daigaku, R., Francis, R., Futter, C., Dikic, I., & Braga, V. (2013). The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy. Developmental Cell, 25(1), 15-28. https://doi.org/10.1016/j.devcel.2013.03.005

Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration (2011)
Journal Article
Oliver, P. L., Finelli, M. J., Edwards, B., Bitoun, E., Butts, D. L., Becker, E. B. E., Cheeseman, M. T., Davies, B., & Davies, K. E. (2011). Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration. PLoS Genetics, 7(10), Article e1002338. https://doi.org/10.1371/journal.pgen.1002338

Oxidative stress is a common etiological feature of neurological disorders, although the pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration remain unclear. We have identified the role of oxidation resistance 1 (Ox... Read More about Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration.

AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development (2009)
Journal Article
Bitoun, E., Finelli, M. J., Oliver, P. L., Lee, S., & Davies, K. E. (2009). AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development. Journal of Neuroscience, 29(49), 15366-15374. https://doi.org/10.1523/jneurosci.5188-09.2009

Deregulation of the insulin-like growth factor 1 (IGF-1) signaling pathway is a recurrent finding in mouse models and human patients with cerebellar ataxia and thus represents a common pathological cascade in neuronal cell death that may be targeted... Read More about AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development.