All Outputs (8)

Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly (2018)
Journal Article
Al-Dabbagh, S., McPhee, J. S., Piasecki, M., Stewart, C. E., & Al-Shanti, N. (2019). Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly. Journals of Gerontology, Series A, 74(9), 1375–1385. https://doi.org/10.1093/gerona/gly238

The key objective of this work was to investigate the impact of young and old human lymphocyte secretomes on C2C12 myoblasts regeneration. Conditioned media (CMs) were harvested from isolated young and older lymphocytes treated with (activated AC), o... Read More about Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly.

The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans (2018)
Journal Article
Wilkinson, D. J., Piasecki, M., & Atherton, P. J. (2018). The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans. Ageing Research Reviews, 47, 123-132. https://doi.org/10.1016/j.arr.2018.07.005

Age-related loss of skeletal muscle mass and function, sarcopenia, is associated with physical frailty and increased risk of morbidity (chronic diseases), in addition to all-cause mortality. The loss of muscle mass occurs incipiently from middle-age... Read More about The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans.

Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls (2018)
Journal Article
Piasecki, J., McPhee, J., Hannam, K., Deere, K., Elhakeem, A., Piasecki, M., Degens, H., Tobias, J., & Ireland, A. (2018). Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls. Archives of Osteoporosis, 13, https://doi.org/10.1007/s11657-018-0486-9

Summary: We examined bone density in older athletes and controls. Sprinters had greater hip and spine bone density than endurance athletes and controls, whereas values were similar in the latter two groups. These results could not be explained by dif... Read More about Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls.

Handgrip strength cannot be assumed a proxy for overall muscle strength (2018)
Journal Article
Yeung, S. S., Reijnierse, E. M., Trappenburg, M. C., Hogrel, J.-Y., McPhee, J. S., Piasecki, M., Sipila, S., Salpakoski, A., Butler-Browne, G., Pääsuke, M., Gapeyeva, H., Narici, M. V., Meskers, C. G., & Maier, A. B. (2018). Handgrip strength cannot be assumed a proxy for overall muscle strength. Journal of the American Medical Directors Association, 19(8), 703-709. https://doi.org/10.1016/j.jamda.2018.04.019

Objectives: Dynapenia, low muscle strength, is predictive for negative health outcomes and is usually expressed as handgrip strength (HGS). Whether HGS can be a proxy for overall muscle strength and whether this depends on age and health status is co... Read More about Handgrip strength cannot be assumed a proxy for overall muscle strength.

Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men (2018)
Journal Article
Piasecki, M., Ireland, A., Piasecki, J., Stashuk, D., Swiecicka, A., Rutter, M., Jones, D., & McPhee, J. (2018). Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men. Journal of Physiology, 596(9), https://doi.org/10.1113/JP275520

Sarcopenia results from the progressive loss of skeletal muscle mass and reduced function in older age. It is likely to be associated with the well‐documented reduction of motor unit numbers innervating limb muscles and the increase in size of surviv... Read More about Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men.

The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia (2018)
Journal Article
McPhee, J. S., Cameron, J., Maden-Wilkinson, T., Piasecki, M., Yap, M. H., Jones, D. A., & Degens, H. (2018). The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia. Journals of Gerontology, Series A, 73(10), 1287-1294. https://doi.org/10.1093/gerona/gly040

The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia remain unclear. To investigate, 40 older (20 women; age 72 ± 4 years) and 31 younger adults (15 women, age 22 ± 3 years) comple... Read More about The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia.

The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners (2018)
Journal Article
Piasecki, J., Ireland, A., Piasecki, M., Cameron, J., McPhee, J. S., & Degens, H. (2018). The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners. Scandinavian Journal of Medicine and Science in Sports, 28(5), 1559-1568. https://doi.org/10.1111/sms.13062

Regular intense endurance exercise can lead to amenorrhea with possible adverse consequences for bone health. We compared whole body and regional bone strength and skeletal muscle characteristics between amenorrheic (AA: n = 14) and eumenorrheic (EA:... Read More about The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners.

The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles (2018)
Journal Article
Piasecki, M., Ireland, A., Piasecki, J., Stashuk, D., McPhee, J., & Jones, D. (2018). The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles. European Journal of Applied Physiology, 118(4), 767-775. https://doi.org/10.1007/s00421-018-3811-5

Purpose

Current methods for estimating muscle motor unit (MU) number provide values which are remarkably similar for muscles of widely differing size, probably because surface electrodes sample from similar and relatively small volumes in each mus... Read More about The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles.