All Outputs (6)

Sex and age affect depot expression of Ca2+ channels in rat white fat adipocytes (2024)
Journal Article
Meng, Y., Toledo-Rodriguez, M., Fedorenko, O. A., & Smith, P. A. (2024). Sex and age affect depot expression of Ca2+ channels in rat white fat adipocytes. Journal of Molecular Endocrinology, 72(4), Article e230108. https://doi.org/10.1530/JME-23-0108

White adipose tissue (WAT) requires extracellular Ca2+ influx for lipolysis, differentiation, and expansion. This partly occurs via plasma membrane Ca2+ voltage-dependent channels (CaVs). However, WFA exists in different depots whose function varies... Read More about Sex and age affect depot expression of Ca2+ channels in rat white fat adipocytes.

Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression (2020)
Journal Article
Villota, S. D., Toledo-Rodriguez, M., & Leach, L. (2021). Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression. Diabetologia, 64, 195-210. https://doi.org/10.1007/s00125-020-05290-6

© 2020, The Author(s). Aims/hypothesis: Reduced occupancy of junctional occludin is a feature of human placental vessels in the diabetic milieu. However, the functional consequence of this and whether this loss is due to differential expression of oc... Read More about Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression.

Hippocampal TET1 and TET2 expression and DNA hydroxymethylation are affected by physical exercise in aged mice (2018)
Journal Article
Jessop, P., & Toledo-Rodriguez, M. (2018). Hippocampal TET1 and TET2 expression and DNA hydroxymethylation are affected by physical exercise in aged mice. Frontiers in Cell and Developmental Biology, 6, Article 45. https://doi.org/10.3389/fcell.2018.00045

The function of 5-hydroxymethylcytosine (5hmC) is poorly understood. 5hmC is an epigenetic modification of DNA, resulting from the oxidation of 5-methylcytosine (5mC) by the Fe2+, and 2-oxoglutarate-dependent, 10–11 translocation methylcytosine dioxy... Read More about Hippocampal TET1 and TET2 expression and DNA hydroxymethylation are affected by physical exercise in aged mice.

Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia (2016)
Journal Article
Gaskin, P. L., Toledo-Rodriguez, M., Alexander, S. P., & Fone, K. C. (in press). Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia. International Journal of Neuropsychopharmacology, https://doi.org/10.1093/ijnp/pyw062

Background: Dysfunction of dopaminergic, GABAergic and glutamatergic function underlies many core symptoms of schizophrenia. Combined neonatal injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, phencyclidine (PCP) and post-weaning soci... Read More about Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia.

Reconstruction and Simulation of Neocortical Microcircuitry (2015)
Journal Article
Graham, J., Gevaert, M., Berger, T., Kahou, G., Sanchez, C., Reimann, M., …Schürmann, F. (2015). Reconstruction and Simulation of Neocortical Microcircuitry. Cell, 163(2), 456-492. https://doi.org/10.1016/j.cell.2015.09.029

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from spa... Read More about Reconstruction and Simulation of Neocortical Microcircuitry.

Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety (2015)
Journal Article
Pan-Vazquez, A., Rye, N., Ameri, M., McSparron, B., Smallwood, G., Bickerdyke, J., …Toledo-Rodriguez, M. (2015). Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety. Molecular Brain, 8(1), https://doi.org/10.1186/s13041-015-0128-8

Background: Lack of physical activity and increased levels of stress contribute to the development of multiple physical and mental disorders. An increasing number of studies relate voluntary exercise with greater resilience to psychological stress, a... Read More about Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety.