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Reconstruction and Simulation of Neocortical Microcircuitry

Graham, Joe W.; Gevaert, Michael Emiel; Berger, Thomas K.; Kahou, Guy Antoine Atenekeng; Sanchez, Carlos Aguado; Reimann, Michael W.; Markram, Henry; Muller, Eilif; Ramaswamy, Srikanth; Reimann, Michael W.; Abdellah, Marwan; Sanchez, Carlos Aguado; Ailamaki, Anastasia; Alonso-Nanclares, Lidia; Antille, Nicolas; Arsever, Selim; Kahou, Guy Antoine Atenekeng; Berger, Thomas K.; Bilgili, Ahmet; Buncic, Nenad; Chalimourda, Athanassia; Chindemi, Giuseppe; Courcol, Jean-Denis; Delalondre, Fabien; Delattre, Vincent; Druckmann, Shaul; Dumusc, Raphael; Dynes, James; Eilemann, Stefan; Gal, Eyal; Gevaert, Michael Emiel; Ghobril, Jean-Pierre; Gidon, Albert; Graham, Joe W.; Gupta, Anirudh; Haenel, Valentin; Hay, Etay; Heinis, Thomas; Hernando, Juan B.; Hines, Michael; Kanari, Lida; Keller, Daniel; Kenyon, John; Khazen, Georges; Kim, Yihwa; King, James G.; Kisvarday, Zoltan; Kumbhar, Pramod; Lasserre, Sébastien; Le Bé, Jean-Vincent; Magalhães, Bruno R.C.; Merchán-Pérez, Angel; Meystre, Julie; Morrice, Benjamin Roy; Muller, Jeffrey; Muñoz-Céspedes, Alberto; Muralidhar, Shruti; Muthurasa, Keerthan; Nachbaur, Daniel; Newton, Taylor H.; Nolte, Max; Ovcharenko, Aleksandr; Palacios, Juan; Pastor, Luis; Perin, Rodrigo; Ranjan, Rajnish; Riachi, Imad; Rodríguez, José-Rodrigo; Riquelme, Juan Luis; Rössert, Christian; Sfyrakis, Konstantinos; Shi, Ying; Shillcock, Julian C.; Silberberg, Gilad; Silva, Ricardo; Tauheed, Farhan; Telefont, Martin; Toledo-Rodriguez, Maria; Tränkler, Thomas; Van Geit, Werner; Díaz, Jafet Villafranca; Walker, Richard; Wang, Yun; Zaninetta, Stefano M.; DeFelipe, Javier; Hill, Sean L.; Segev, Idan; Schürmann, Felix

Authors

Joe W. Graham

Michael Emiel Gevaert

Thomas K. Berger

Guy Antoine Atenekeng Kahou

Carlos Aguado Sanchez

Michael W. Reimann

Henry Markram

Eilif Muller

Srikanth Ramaswamy

Michael W. Reimann

Marwan Abdellah

Carlos Aguado Sanchez

Anastasia Ailamaki

Lidia Alonso-Nanclares

Nicolas Antille

Selim Arsever

Guy Antoine Atenekeng Kahou

Thomas K. Berger

Ahmet Bilgili

Nenad Buncic

Athanassia Chalimourda

Giuseppe Chindemi

Jean-Denis Courcol

Fabien Delalondre

Vincent Delattre

Shaul Druckmann

Raphael Dumusc

James Dynes

Stefan Eilemann

Eyal Gal

Michael Emiel Gevaert

Jean-Pierre Ghobril

Albert Gidon

Joe W. Graham

Anirudh Gupta

Valentin Haenel

Etay Hay

Thomas Heinis

Juan B. Hernando

Michael Hines

Lida Kanari

Daniel Keller

John Kenyon

Georges Khazen

Yihwa Kim

James G. King

Zoltan Kisvarday

Pramod Kumbhar

Sébastien Lasserre

Jean-Vincent Le Bé

Bruno R.C. Magalhães

Angel Merchán-Pérez

Julie Meystre

Benjamin Roy Morrice

Jeffrey Muller

Alberto Muñoz-Céspedes

Shruti Muralidhar

Keerthan Muthurasa

Daniel Nachbaur

Taylor H. Newton

Max Nolte

Aleksandr Ovcharenko

Juan Palacios

Luis Pastor

Rodrigo Perin

Rajnish Ranjan

Imad Riachi

José-Rodrigo Rodríguez

Juan Luis Riquelme

Christian Rössert

Konstantinos Sfyrakis

Ying Shi

Julian C. Shillcock

Gilad Silberberg

Ricardo Silva

Farhan Tauheed

Martin Telefont

Thomas Tränkler

Werner Van Geit

Jafet Villafranca Díaz

Richard Walker

Yun Wang

Stefano M. Zaninetta

Javier DeFelipe

Sean L. Hill

Idan Segev

Felix Schürmann



Abstract

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm3 containing ∼31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ∼8 million connections with ∼37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies.

Journal Article Type Article
Publication Date 2015-10
Journal Cell
Print ISSN 0092-8674
Electronic ISSN 0092-8674
Publisher Elsevier (Cell Press)
Peer Reviewed Peer Reviewed
Volume 163
Issue 2
Pages 456-492
APA6 Citation Graham, J., Gevaert, M., Berger, T., Kahou, G., Sanchez, C., Reimann, M., …Schürmann, F. (2015). Reconstruction and Simulation of Neocortical Microcircuitry. Cell, 163(2), 456-492. https://doi.org/10.1016/j.cell.2015.09.029
DOI https://doi.org/10.1016/j.cell.2015.09.029
Keywords General Biochemistry, Genetics and Molecular Biology
Publisher URL http://www.sciencedirect.com/science/article/pii/S0092867415011915
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This article is maintained by: Elsevier; Article Title: Reconstruction and Simulation of Neocortical Microcircuitry; Journal Title: Cell; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.cell.2015.09.029; Content Type: article; Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.
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