All Outputs (24)

Elementary effects for models with dimensional inputs of arbitrary type and range: Scaling and trajectory generation (2023)
Journal Article

The Elementary Effects method is a global sensitivity analysis approach for identifying (un)important parameters in a model. However, it has almost exclusively been used where inputs are dimensionless and take values on [0, 1]. Here, we consider mode... Read More about Elementary effects for models with dimensional inputs of arbitrary type and range: Scaling and trajectory generation.

Modelling how plant cell-cycle progression leads to cell size regulation (2023)
Journal Article

Populations of cells typically maintain a consistent size, despite cell division rarely being precisely symmetrical. Therefore, cells must possess a mechanism of “size control”, whereby the cell volume at birth affects cell-cycle progression. While s... Read More about Modelling how plant cell-cycle progression leads to cell size regulation.

Multiscale asymptotic analysis reveals how cell growth and subcellular compartments affect tissue-scale hormone transport (2023)
Journal Article

Determining how cell-scale processes lead to tissue-scale patterns is key to understanding how hormones and morphogens are distributed within biological tissues and control developmental processes. In this article, we use multiscale asymptotic analys... Read More about Multiscale asymptotic analysis reveals how cell growth and subcellular compartments affect tissue-scale hormone transport.

Gibberellin and abscisic acid transporters facilitate endodermal suberin formation in Arabidopsis (2023)
Journal Article

The plant hormone gibberellin (GA) regulates multiple developmental processes. It accumulates in the root elongating endodermis, but how it moves into this cell file and the significance of this accumulation are unclear. Here we identify three NITRAT... Read More about Gibberellin and abscisic acid transporters facilitate endodermal suberin formation in Arabidopsis.

Long-distance hormone transport via the phloem (2023)
Journal Article

Several key plant hormones are synthesised in the shoot and are advected within the phloem to the root tip. In the root tip, these hormones regulate growth and developmental processes, and responses to environmental cues. However, we lack understandi... Read More about Long-distance hormone transport via the phloem.

In silico evidence for the utility of parsimonious root phenotypes for improved vegetative growth and carbon sequestration under drought (2022)
Journal Article

Drought is a primary constraint to crop yields and climate change is expected to increase the frequency and severity of drought stress in the future. It has been hypothesized that crops can be made more resistant to drought and better able to sequest... Read More about In silico evidence for the utility of parsimonious root phenotypes for improved vegetative growth and carbon sequestration under drought.

Uncertainty and error in SARS-CoV-2 epidemiological parameters inferred from population-level epidemic models (2022)
Journal Article

During the SARS-CoV2 pandemic, epidemic models have been central to policy-making. Public health responses have been shaped by model-based projections and inferences, especially related to the impact of various non-pharmaceutical interventions. Accom... Read More about Uncertainty and error in SARS-CoV-2 epidemiological parameters inferred from population-level epidemic models.

Modeling root loss reveals impacts on nutrient uptake and crop development (2022)
Journal Article

Abstract Despite the widespread prevalence of root loss in plants, its effects on crop productivity are not fully understood. While root loss reduces the capacity of plants to take up water and nutrients from the soil, it may provide benefits by decr... Read More about Modeling root loss reveals impacts on nutrient uptake and crop development.

Modelling reveals post-transcriptional regulation of GA metabolism enzymes in response to drought and cold (2022)
Journal Article

The hormone gibberellin (GA) controls plant growth and regulates growth responses to environmental stress. In monocotyledonous leaves, GA controls growth by regulating division-zone size. We used a systems approach to investigate the establishment of... Read More about Modelling reveals post-transcriptional regulation of GA metabolism enzymes in response to drought and cold.

Systems approaches reveal that ABCB and PIN proteins mediate co-dependent auxin efflux (2022)
Journal Article

Members of the B family of membrane-bound ATP-binding cassette (ABC) transporters represent key components of the auxin-efflux machinery in plants. Over the last two decades experimental studies have shown that modifying ABCB expression affects auxin... Read More about Systems approaches reveal that ABCB and PIN proteins mediate co-dependent auxin efflux.

Integrated root phenotypes for improved rice performance under low nitrogen availability (2022)
Journal Article

Greater nitrogen efficiency would substantially reduce the economic, energy and environmental costs of rice production. We hypothesized that synergistic balancing of the costs and benefits for soil exploration among root architectural phenes is benef... Read More about Integrated root phenotypes for improved rice performance under low nitrogen availability.

Auxin fluxes through plasmodesmata (2021)
Journal Article

Characterising the processes that control auxin dynamics is essential to understanding how auxin regulates plant development. Over recent years, several studies have investigated auxin diffusion through plasmodesmata, characterising this cell-to-cell... Read More about Auxin fluxes through plasmodesmata.

Differential biosynthesis and cellular permeability explain longitudinal gibberellin gradients in growing roots (2021)
Journal Article

Control over cell growth by mobile regulators underlies much of eukaryotic morphogenesis. In plant roots, cell division and elongation are separated into distinct longitudinal zones and both division and elongation are influenced by the growth regula... Read More about Differential biosynthesis and cellular permeability explain longitudinal gibberellin gradients in growing roots.

Roots or Flowers? Take a Guess (2020)
Book Chapter

Phosphorus is a growth-limiting nutrient for plants. The use of phosphate (Pi) fertiliser is unsustainable because its stocks are non-renew-able and the run-off of surplus fertiliser damages the environment.

Auxin fluxes through plasmodesmata modify root-tip auxin distribution (2020)
Journal Article

© 2020. Published by The Company of Biologists Ltd. Auxin is a key signal regulating plant growth and development. It is well established that auxin dynamics depend on the spatial distribution of efflux and influx carriers on the cell membranes. In t... Read More about Auxin fluxes through plasmodesmata modify root-tip auxin distribution.

Parameter inference to motivate asymptotic model reduction: an analysis of the gibberellin biosynthesis pathway (2018)
Journal Article
Band, L. R., & Preston, S. P. (2018). Parameter inference to motivate asymptotic model reduction: an analysis of the gibberellin biosynthesis pathway. Journal of Theoretical Biology, 457, 66-78. https://doi.org/10.1016/j.jtbi.2018.05.028

Developing effective strategies to use models in conjunction with experimental data is essential to understand the dynamics of biological regulatory networks. In this study, we demonstrate how combining parameter estimation with asymptotic analysis c... Read More about Parameter inference to motivate asymptotic model reduction: an analysis of the gibberellin biosynthesis pathway.

Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network (2018)
Journal Article
Scofield, S., Murison, A., Jones, A., Fozard, J., Aida, M., Band, L. R., …Murray, J. A. (2018). Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network. Development, 145(9), Article dev157081. https://doi.org/10.1242/dev.157081

© 2018. Published by The Company of Biologists Ltd. The Arabidopsis homeodomain transcription factor SHOOT MERISTEMLESS (STM) is crucial for shoot apical meristem (SAM) function, yet the components and structure of the STM gene regulatory network (GR... Read More about Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network.

Biphasic regulation of the transcription factor ABORTED MICROSPORES (AMS) is essential for tapetum and pollen development in Arabidopsis (2016)
Journal Article
Ferguson, A., Pearce, S., Band, L. R., Yang, C., Ferjentsikova, I., King, J., …Wilson, Z. A. (in press). Biphasic regulation of the transcription factor ABORTED MICROSPORES (AMS) is essential for tapetum and pollen development in Arabidopsis. New Phytologist, 213, https://doi.org/10.1111/nph.14200

Viable pollen is essential for plant reproduction and crop yield. Its production requires coordinated expression at specific stages during anther development, involving early meiosis-associated events and late pollen wall formation. The ABORTED MICRO... Read More about Biphasic regulation of the transcription factor ABORTED MICROSPORES (AMS) is essential for tapetum and pollen development in Arabidopsis.

Dynamic regulation of auxin oxidase and conjugating enzymes AtDAO1 and GH3 modulates auxin homeostasis (2016)
Journal Article
Mellor, N. L., Band, L. R., Pěnčík, A., Novak, O., Rashed, A., Holman, T., …Owen, M. R. (2016). Dynamic regulation of auxin oxidase and conjugating enzymes AtDAO1 and GH3 modulates auxin homeostasis. Proceedings of the National Academy of Sciences, 113(39), 11022-11027. https://doi.org/10.1073/pnas.1604458113

Auxin is a key hormone regulating plant growth and development. We combine experiments and mathematical modeling to reveal how auxin levels are maintained via feedback regulation of genes encoding key metabolic enzymes. We describe how regulation of... Read More about Dynamic regulation of auxin oxidase and conjugating enzymes AtDAO1 and GH3 modulates auxin homeostasis.

Cyclic programmed cell death stimulates hormone signaling and root development in Arabidopsis (2016)
Journal Article
Xuan, W., Band, L. R., Kumpf, R. P., Van Damme, D., Parizot, B., De Rop, G., …Beeckman, T. (2016). Cyclic programmed cell death stimulates hormone signaling and root development in Arabidopsis. Science, 351(6271), 384-387. https://doi.org/10.1126/science.aad2776

The plant root cap, surrounding the very tip of the growing root, perceives and transmits environmental signals to the inner root tissues. In Arabidopsis thaliana, auxin released by the root cap contributes to the regular spacing of lateral organs al... Read More about Cyclic programmed cell death stimulates hormone signaling and root development in Arabidopsis.