All Outputs (28)

Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells (2017)
Journal Article
Choi, M., Genereux, D. P., Goodson, J., Al-Azzawi, H., Allain, S. Q., Simon, N., …Laird, C. D. (2017). Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells. PLoS Genetics, 13(11), Article e1007060. https://doi.org/10.1371/journal.pgen.1007060

In storing and transmitting epigenetic information, organisms must balance the need to maintain information about past conditions with the capacity to respond to information in their current and future environments. Some of this information is encode... Read More about Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells.

Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin (2017)
Journal Article
Zeebaree, B. K., Kwong, W. Y., Mann, G. E., Gutierrez, C. G., & Sinclair, K. D. (2018). Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin. Theriogenology, 105, https://doi.org/10.1016/j.theriogenology.2017.09.014

Our understanding of the effects of temperature on granulosa cell (GC) physiology is primarily limited to in vitro studies conducted under atmospheric (approx 20% O2) conditions. In the current series of factorial experiments we identify important ef... Read More about Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin.

Epigenetics and developmental programming of welfare and production traits in farm animals (2016)
Journal Article
Sinclair, K. D., Rutherford, K., Wallace, J., Brameld, J., Stöger, R., Alberio, R., …Dwyer, C. (in press). Epigenetics and developmental programming of welfare and production traits in farm animals. Reproduction, Fertility and Development, 28(10), https://doi.org/10.1071/RD16102

The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referr... Read More about Epigenetics and developmental programming of welfare and production traits in farm animals.

Molecular determinants of a competent bovine corpus luteum: first- vs final-wave dominant follicles (2016)
Journal Article
Gregson, E., Webb, R., Sheldrick, E. L., Campbell, B. K., Mann, G. E., Liddell, S., & Sinclair, K. D. (2016). Molecular determinants of a competent bovine corpus luteum: first- vs final-wave dominant follicles. Reproduction, 151(6), 563-575. https://doi.org/10.1530/REP-15-0415

Reproductive management in cattle requires the synchrony of follicle development and oestrus before insemination. However, ovulation of follicles that have not undergone normal physiological maturation can lead to suboptimal luteal function. Here, we... Read More about Molecular determinants of a competent bovine corpus luteum: first- vs final-wave dominant follicles.

The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals (2016)
Journal Article
Lea, R. G., Amezaga, M. R., Loup, B., Mandon- Pépin, B., Stefansdottir, A., Filis, P., …Fowler, P. . A. (2016). The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals. Scientific Reports, 6, 22279. https://doi.org/10.1038/srep22279

The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on... Read More about The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals.

In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver (2015)
Journal Article
Drake, A. J., O'Shaughnessy, P. J., Bhattachyrya, S., Monteiro, A., Kerrigan, D., Goetz, S., …Fowler, P. A. (2015). In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver. BMC Medicine, 13, https://doi.org/10.1186/s12916-014-0251-x

Background: Maternal smoking is one of the most important modifiable risk factors for low birthweight, which is strongly associated with increased cardiometabolic disease risk in adulthood. Maternal smoking reduces the levels of the methyl donor vita... Read More about In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver.

Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development (2014)
Journal Article
Dunford, L. J., Sinclair, K. D., Kwong, W. Y., Sturrock, C., Clifford, B. L., Giles, T. C., & Gardner, D. S. (2014). Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development. FASEB Journal, 28(11), 4880-4892. https://doi.org/10.1096/fj.14-255364

This paper identifies a common nutritional pathway relating maternal through to fetal protein-energy malnutrition (PEM) and compromised fetal kidney development. Thirty-one twin-bearing sheep were fed either a control (n=15) or low-protein diet (n=16... Read More about Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development.

Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice (2014)
Journal Article
Watkins, A. J., & Sinclair, K. D. (2014). Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice. AJP - Heart and Circulatory Physiology, 306(10), Article H1444-H1452. https://doi.org/10.1152/ajpheart.00981.2013

Whilst the association between maternal periconceptional diet and adult offspring health is well characterised, our understanding of the impact of paternal nutrition at the time of conception on offspring phenotype remains poorly defined. Therefore,... Read More about Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice.