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Maternal one-carbon metabolism during the periconceptional period and human foetal brain growth: A systematic review (2021)
Journal Article
Rubini, E., Baijens, I. M., Horánszky, A., Schoenmakers, S., Sinclair, K. D., Zana, M., Dinnyés, A., Steegers-Theunissen, R. P., & Rousian, M. (2021). Maternal one-carbon metabolism during the periconceptional period and human foetal brain growth: A systematic review. Genes, 12(10), Article 1634. https://doi.org/10.3390/genes12101634

The maternal environment during the periconceptional period influences foetal growth and development, in part, via epigenetic mechanisms moderated by one-carbon metabolic pathways. During embryonic development, one-carbon metabolism is involved in br... Read More about Maternal one-carbon metabolism during the periconceptional period and human foetal brain growth: A systematic review.

Preimplantation genetic testing for aneuploidy improves live birth rates with in vitro produced bovine embryos: A blind retrospective study (2021)
Journal Article
Silvestri, G., Canedo-Ribeiro, C., Serrano-Albal, M., Labrecque, R., Blondin, P., Larmer, S. G., Marras, G., Tutt, D. A., Handyside, A. H., Farré, M., Sinclair, K. D., & Griffin, D. K. (2021). Preimplantation genetic testing for aneuploidy improves live birth rates with in vitro produced bovine embryos: A blind retrospective study. Cells, 10(9), Article 2284. https://doi.org/10.3390/cells10092284

Approximately one million in vitro produced (IVP) cattle embryos are transferred world-wide each year as a way to improve the rates of genetic gain. The most advanced programmes also apply genomic selection at the embryonic stage by SNP genotyping an... Read More about Preimplantation genetic testing for aneuploidy improves live birth rates with in vitro produced bovine embryos: A blind retrospective study.

Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation (2021)
Journal Article
Clare, C. E., Pestinger, V., Kwong, W. Y., Tutt, D. A. R., Xu, J., Byrne, H. M., Barrett, D. A., Emes, R. D., & Sinclair, K. D. (2021). Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation. International Journal of Molecular Sciences, 22(4), Article 1838. https://doi.org/10.3390/ijms22041838

One-carbon (1C) metabolism provides methyl groups for the synthesis and/or methylation 20 of purines and pyrimidines, biogenic amines, proteins and phospholipids. Our understanding of 21 how 1C pathways operate, however, pertains mostly to the (rat)... Read More about Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation.