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All Outputs (13)

Galacto-oligosaccharides fed during gestation increase Rotavirus A specific antibodies in sow colostrum, modulate the microbiome, and reduce infectivity in neonatal piglets in a commercial farm setting (2023)
Journal Article

Introduction: Rotavirus A is a major cause of acute dehydrating diarrhea in neonatal pigs resulting in significant mortality, morbidity, reduced performance and economic loss. Commercially available prebiotic galacto-oligosaccharides are similar to t... Read More about Galacto-oligosaccharides fed during gestation increase Rotavirus A specific antibodies in sow colostrum, modulate the microbiome, and reduce infectivity in neonatal piglets in a commercial farm setting.

Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs (2022)
Journal Article

Weaning represents one of the most critical periods in pig production associated with increase in disease risk, reduction in performance and economic loss. Physiological changes faced by piglets during the weaning period have been well characterised,... Read More about Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs.

Common colonic community indicators of the suckling pig microbiota where diversity and abundance correlate with performance (2022)
Journal Article

The primary objective of this study was to investigate if common colonic community indicators could be identified from the microbiota of 22-day-old suckling pigs in repeated small-scale trials. A total of three separate trials were conducted at diffe... Read More about Common colonic community indicators of the suckling pig microbiota where diversity and abundance correlate with performance.

Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus (2021)
Journal Article

The long-term control strategy of SARS-CoV-2 and other major respiratory viruses needs to in-clude antivirals to treat acute infections, in addition to the judicious use of effective vaccines. Whilst COVID-19 vaccines are being rolled out for mass va... Read More about Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus.

An Optimized Reverse Genetics System Suitable for Efficient Recovery of Simian, Human, and Murine-Like Rotaviruses (2020)
Journal Article

Copyright © 2020 American Society for Microbiology. An entirely plasmid-based reverse genetics (RG) system was recently developed for rotavirus (RV), opening new avenues for in-depth molecular dissection of RV biology, immunology, and pathogenesis. S... Read More about An Optimized Reverse Genetics System Suitable for Efficient Recovery of Simian, Human, and Murine-Like Rotaviruses.

Viabilité et quantification d’une levure probiotique dans le système digestif du porc (2016)
Journal Article
Le Bon, M., Bravo de Laguna, F., Chevaux, E., & Mellits, K. H. (in press). Viabilité et quantification d’une levure probiotique dans le système digestif du porc. Journees de la Recherche Porcine en France, 48,

Viability and colonisation of a probiotic yeast in the digestive tract of piglets Probiotics have been defined as « live microorganisms which when administered in adequate amounts confer a health benefit on the host» (WHO, 2001). This definition i... Read More about Viabilité et quantification d’une levure probiotique dans le système digestif du porc.

Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and proinflammatory dysregulation (2015)
Journal Article
Chang, P., Kuchipudi, S. V., Mellits, K., Sebastian, S., James, J., Liu, J., …Chang, K.-C. (2015). Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and proinflammatory dysregulation. Scientific Reports, 5(17999), https://doi.org/10.1038/srep17999

Pigs are evidently more resistant to avian than swine influenza A viruses, mediated in part through frontline epithelial cells and alveolar macrophages (AM). Although porcine AM (PAM) are crucial in influenza virus control, their mode of control is u... Read More about Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and proinflammatory dysregulation.

Efficiency of disinfectants against Rotavirus in the presence and absence of organic matter (2015)
Journal Article
Chandler-Bostock, R., & Mellits, K. (in press). Efficiency of disinfectants against Rotavirus in the presence and absence of organic matter. Letters in Applied Microbiology, 61(6), https://doi.org/10.1111/lam.12502

Rotavirus is an enteric pathogen that causes morbidity and mortality in young mammals, including pigs. Outbreaks of rotavirus on commercial farms have a significant economic impact in terms of losses in production. Effective cleaning and disinfection... Read More about Efficiency of disinfectants against Rotavirus in the presence and absence of organic matter.

Diversity of group A rotavirus on a UK pig farm (2015)
Journal Article
Chandler-Bostock, R., Hancox, L., Payne, H., Iturriza-Gomara, M., Daly, J. M., & Mellits, K. (2015). Diversity of group A rotavirus on a UK pig farm. Veterinary Microbiology, 180(3-4), 205-211. https://doi.org/10.1016/j.vetmic.2015.09.009

Group A rotaviruses (GARV) are a significant cause of enteritis in young pigs. The aim of this study was to extend our understanding of the molecular epidemiology of porcine GARV in the UK by investigating the genetic diversity of GARV on a conventio... Read More about Diversity of group A rotavirus on a UK pig farm.

Genetic diversity of porcine group A rotavirus strains in the UK (2014)
Journal Article
Chandler-Bostock, R., Hancox, L. R., Nawaz, S., Watts, O., Iturriza-Gomara, M., & Mellits, K. M. (2014). Genetic diversity of porcine group A rotavirus strains in the UK. Veterinary Microbiology, 173(1-2), https://doi.org/10.1016/j.vetmic.2014.06.030

Rotavirus is endemic in pig farms where it causes a loss in production. This study is the first to characterise porcine rotavirus circulating in UK pigs. Samples from diarrheic pigs with rotavirus enteritis obtained between 2010 and 2012 were genotyp... Read More about Genetic diversity of porcine group A rotavirus strains in the UK.