All Outputs (22)

High incidence of antibiotic resistance amongst isolates of Helicobacter pylori collected in Nottingham, UK, between 2001 and 2018 (2023)
Journal Article
Garvey, E., Rhead, J., Suffian, S., Whiley, D., Mahmood, F., Bakshi, N., …Robinson, K. (2023). High incidence of antibiotic resistance amongst isolates of Helicobacter pylori collected in Nottingham, UK, between 2001 and 2018. Journal of Medical Microbiology, 72(11), Article 001776. https://doi.org/10.1099/jmm.0.001776

Introduction. Helicobacter pylori is the leading cause of peptic ulcers and gastric cancer. The most common treatment regimens use combinations of two or three antibiotics and a proton pump inhibitor (PPI) to suppress stomach acid. The World Health O... Read More about High incidence of antibiotic resistance amongst isolates of Helicobacter pylori collected in Nottingham, UK, between 2001 and 2018.

Characterization of a Helicobacter pylori strain with high biofilm-forming ability (2023)
Journal Article
Wilkinson, D., Alsharaf, L., Thompson, S., Paulin, A., Takor, R., Zaitoun, A., …Winter, J. (2023). Characterization of a Helicobacter pylori strain with high biofilm-forming ability. Journal of Medical Microbiology, 72(6), Article 001710. https://doi.org/10.1099/jmm.0.001710

Introduction. Helicobacter pylori is highly polymorphic, and some strains are much more likely to cause disease than others. Biofilm formation can help bacteria to survive antibiotic treatment, immune attack and other stresses, promoting persistent i... Read More about Characterization of a Helicobacter pylori strain with high biofilm-forming ability.

The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation (2023)
Journal Article
Nabavi-Rad, A., Jamshidizadeh, S., Azizi, M., Yadegar, A., Robinson, K., Monaghan, T. M., & Reza Zali, M. (2023). The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation. Frontiers in Cellular and Infection Microbiology, 13, Article 1171469

Owing to the emergence and spread of multidrug resistance mechanisms in Helicobacter pylori, achieving a successful eradication has become exceedingly difficult. Thus, this study for the first time determines the effect of a combination of vitamin D3... Read More about The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation.

Genomic diversity of Helicobacter pylori populations from different regions of the human stomach (2022)
Journal Article
Wilkinson, D. J., Dickins, B., Robinson, K., & Winter, J. A. (2022). Genomic diversity of Helicobacter pylori populations from different regions of the human stomach. Gut Microbes, 14(1), Article 2152306. https://doi.org/10.1080/19490976.2022.2152306

Individuals infected with Helicobacter pylori harbor unique and diverse populations of quasispecies, but diversity between and within different regions of the human stomach and the process of bacterial adaptation to each location are not yet well und... Read More about Genomic diversity of Helicobacter pylori populations from different regions of the human stomach.

Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis (2022)
Journal Article
Southern, K. W., Castellani, C., Lammertyn, E., Smyth, A., VanDevanter, D., van Koningsbruggen-Rietschel, S., …Duff, A. (2023). Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis. Journal of Cystic Fibrosis, 22(1), 17-30. https://doi.org/10.1016/j.jcf.2022.10.002

Cystic fibrosis (CF) has entered the era of variant-specific therapy, tailored to the genetic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR modulators, the first variant-specific therapy available, have transfo... Read More about Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis.

The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa (2022)
Journal Article
Kaneko, K., Zaitoun, A. M., Letley, D. P., Rhead, J. L., Torres, J., Spendlove, I., …Robinson, K. (2022). The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa. Journal of Pathology, https://doi.org/10.1002/path.5990

High-level expression of decay-accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues. Therapeutic effects of CD55 inhibition in cancer have been reported. However, the role of Helicob... Read More about The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa.

A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19 (2021)
Preprint / Working Paper
Khan, F., Fabbri, L., Stewart, I., Robinson A., K., Smyth, A. R., & Jenkins, G. A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19

Background There is accumulating evidence for an overly activated immune response in severe Covid-19, with several studies exploring the therapeutic role of immunomodulation. Through systematic review and meta-analysis, we assess the effectiveness of... Read More about A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19.

Narrow band imaging and serology in the assessment of premalignant gastric pathology (2019)
Journal Article
White, J. R., Sami, S. S., Reddiar, D., Mannath, J., Ortiz Fernández-Sordo, J., Beg, S., …Ragunath, K. (2019). Narrow band imaging and serology in the assessment of premalignant gastric pathology. Scandinavian Journal of Gastroenterology, 53(12), 1611-1618. https://doi.org/10.1080/00365521.2018.1542455

Background: Patient outcomes in gastric adenocarcinoma are poor due to late diagnosis. Detecting and treating at the premalignant stage has the potential to improve this. Helicobacter pylori is also a strong risk factor for this disease.

Aims: Pri... Read More about Narrow band imaging and serology in the assessment of premalignant gastric pathology.

Association Between ABO Blood Groups and Helicobacter pylori Infection: A Meta-Analysis (2018)
Journal Article
Chakrani, Z., Robinson, K., & Taye, B. (2018). Association Between ABO Blood Groups and Helicobacter pylori Infection: A Meta-Analysis. Scientific Reports, 8(1), Article 17604. https://doi.org/10.1038/s41598-018-36006-x

There is no consensus among the existing literature on the relationship between ABO blood groups and risk of Helicobacter pylori infection. However, histo-blood group carbohydrates are proposed to influence the risk of acquiring this pathogen via eff... Read More about Association Between ABO Blood Groups and Helicobacter pylori Infection: A Meta-Analysis.

Association between infection with H. pylori and atopy in young Ethiopian children: a longitudinal study (2017)
Journal Article
Taye, B., Enquselassie, F., Tsegaye, A., Amberbir, A., Medhin, G., Fogarty, A. W., …Davey, G. (in press). Association between infection with H. pylori and atopy in young Ethiopian children: a longitudinal study. Clinical and Experimental Allergy, 47(10), https://doi.org/10.1111/cea.12995

Background: Epidemiological evidence from developed countries indicates that Helicobacter pylori infection correlates with a reduced risk of atopy and allergic disorders, however limited data are available from low-income countries.

Objective: We... Read More about Association between infection with H. pylori and atopy in young Ethiopian children: a longitudinal study.

Effect of Helicobacter pylori infection on growth trajectories in young Ethiopian children: a longitudinal study (2016)
Journal Article
Taye, B., Enquselassie, F., Tsegaye, A., Amberbir, A., Medhin, G., Fogarty, A., …Davey, G. (2016). Effect of Helicobacter pylori infection on growth trajectories in young Ethiopian children: a longitudinal study. International Journal of Infectious Diseases, 50, 57-66. https://doi.org/10.1016/j.ijid.2016.08.005

Background
Helicobacter pylori infection has been associated with early childhood growth impairment in high- and middle-income countries; however, few studies have examined this relationship within low-income countries or have used a longitudinal de... Read More about Effect of Helicobacter pylori infection on growth trajectories in young Ethiopian children: a longitudinal study.

Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy (2016)
Journal Article
Sinnett, C. G., Letley, D. P., Narayana, G. L., Patel, S. R., Hussein, N. R., Zaitoun, A. M., Robinson, K., & Atherton, J. C. (2016). Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy. Journal of Clinical Pathology, 69(11), 968-973. https://doi.org/10.1136/jclinpath-2016-203641

Aims Helicobacter pylori infection is the major cause of peptic ulceration and gastric cancer, and an important virulence determinant is its vacuolating cytotoxin, vacA. Previously, we have described allelic variation in vacA which determines toxin a... Read More about Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy.

Helicobacter pylori-mediated protection from allergy is associated with IL-10-secreting peripheral blood regulatory T cells (2016)
Journal Article
Hussain, K., Letley, D. P., Greenaway, A. B., Kenefeck, R., Winter, J. A., Tomlinson, W., …Robinson, K. (2016). Helicobacter pylori-mediated protection from allergy is associated with IL-10-secreting peripheral blood regulatory T cells. Frontiers in Immunology, 7, Article 71. https://doi.org/10.3389/fimmu.2016.00071

© 2016 Hussain, Letley, Greenaway, Kenefeck, Winter, Tomlinson, Rhead, Staples, Kaneko, Atherton and Robinson. Helicobacter pylori infections are usually established in early childhood and continuously stimulate immunity, including T-helper 1 (Th1),... Read More about Helicobacter pylori-mediated protection from allergy is associated with IL-10-secreting peripheral blood regulatory T cells.

Expression of the Helicobacter pylori virulence factor vacuolating cytotoxin A (vacA) is influenced by a potential stem-loop structure in the 5' untranslated region of the transcript (2015)
Journal Article

The vacuolating cytotoxin, VacA, is an important virulence factor secreted by the gastric pathogen Helicobacter pylori. Certain vacA genotypes are strongly associated with disease risk, but the association is not absolute. The factors determining vac... Read More about Expression of the Helicobacter pylori virulence factor vacuolating cytotoxin A (vacA) is influenced by a potential stem-loop structure in the 5' untranslated region of the transcript.

Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children (2015)
Journal Article
Taye, B., Enquselassie, F., Tsegaye, A., Amberbir, A., Medhin, G., Fogarty, A. W., …Davey, G. (2015). Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children. BMC Infectious Diseases, 15(1), Article 270. https://doi.org/10.1186/s12879-015-1012-y

Background

Epidemiological and clinical studies in high income countries have suggested that Helicobacter pylori (H. pylori) may cause anaemia, but evidence is lacking from low income countries.We examined associations between H. pylori infection... Read More about Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children.

Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis (2015)
Journal Article
Cook, K. W., Crooks, J., Hussain, K., O'Brien, K., Braitch, M., Kareem, H., Constantinescu, C. S., Robinson, K., & Gran, B. (2015). Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis. Frontiers in Microbiology, 6, Article 52. https://doi.org/10.3389/fmicb.2015.00052

Recent research has demonstrated that infection with the bacterial pathogen Helicobacter pylori is less common amongst patients with multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS). We aimed to compa... Read More about Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis.

Gut reactions (2014)
Journal Article
Robinson, K. (2014). Gut reactions

A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach (2014)
Journal Article
Winter, J., Letley, D., Cook, K., Rhead, J., Zaitoun, A., Ingram, R., Amilon, K., Croxall, N., Kaye, P., Robinson, K., & Atherton, J. (2014). A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach. Journal of Infectious Diseases, 210(6), 954–963. https://doi.org/10.1093/infdis/jiu154

Carriage of Helicobacter pylori strains producing more active (s1/i1) forms of VacA is strongly associated with gastric adenocarcinoma. To our knowledge, we are the first to determine effects of different polymorphic forms of VacA on inflammation and... Read More about A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach.

CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa (2014)
Journal Article
Cook, K. W., Letley, D. P., Ingram, R. J., Staples, E., Skjoldmose, H., Atherton, J. C., & Robinson, K. (2014). CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa. Gut, 63(10), 1550-1559. https://doi.org/10.1136/gutjnl-2013-306253

Background Helicobacter pylori-induced peptic ulceration is less likely to occur in patients with a strong gastric anti-inflammatory regulatory T cell (Treg) response. Migration of Tregs into the gastric mucosa is therefore important.

Objective To... Read More about CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa.

Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells (2014)
Journal Article
Winter, J., Letley, D., Rhead, J., Atherton, J., & Robinson, K. (2014). Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells. Infection and Immunity, 82(4), 1372-1381. https://doi.org/10.1128/iai.01443-13

Persistent Helicobacter pylori infection induces chronic inflammation in the human gastric mucosa, which is associated with development of peptic ulceration, gastric atrophy, and gastric adenocarcinoma. It has been postulated that secretion of immuno... Read More about Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells.