Jonathan R White
Narrow band imaging and serology in the assessment of premalignant gastric pathology
White, Jonathan R; Sami, Sarmed S; Reddiar, Dona; Mannath, Jayan; Ortiz Fern�ndez-Sordo, Jacobo; Beg, Sabina; Scott, Robert; Thiagarajan, Prarthana; Ahmad, Saqib; Parra-Blanco, Adolfo; Kasi, Madhavi; Telakis, Emmanouil; Sultan, Alyshah A; Davis, Jillian; Figgins, Adam; Kaye, Philip; Robinson, Karen; Atherton, John C; Ragunath, Krish
Authors
Sarmed S Sami
Dona Reddiar
Jayan Mannath
Jacobo Ortiz Fern�ndez-Sordo
Sabina Beg
Robert Scott
Prarthana Thiagarajan
Saqib Ahmad
Adolfo Parra-Blanco
Madhavi Kasi
Emmanouil Telakis
Alyshah A Sultan
Jillian Davis
Adam Figgins
Philip Kaye
Professor KAREN ROBINSON karen.robinson@nottingham.ac.uk
PROFESSOR IN GASTROINTESTINAL INFECTION AND IMMUNITY
John C Atherton
Krish Ragunath
Abstract
Background: Patient outcomes in gastric adenocarcinoma are poor due to late diagnosis. Detecting and treating at the premalignant stage has the potential to improve this. Helicobacter pylori is also a strong risk factor for this disease.
Aims: Primary aims were to assess the diagnostic accuracy of magnified narrow band imaging (NBI-Z) endoscopy and serology in detecting normal mucosa, H. pylori gastritis and gastric atrophy. Secondary aims were to compare the diagnostic accuracies of two classification systems using both NBI-Z and white light endoscopy with magnification (WLE-Z) and evaluate the inter-observer agreement.
Methods: Patients were prospectively recruited. Images of gastric mucosa were stored with histology and serum for IgG H. pylori and Pepsinogen (PG) I/II ELISAs. Blinded expert endoscopists agreed on mucosal pattern. Mucosal images and serological markers were compared with histology. Kappa statistics determined inter-observer variability for randomly allocated images among four experts and four non-experts.
Results: 116 patients were prospectively recruited. Diagnostic accuracy of NBI-Z for determining normal gastric mucosa was 0.87(95%CI 0.82–0.92), H. pylori gastritis 0.65(95%CI 0.55–0.75) and gastric atrophy 0.88(95%CI 0.81–0.94). NBI-Z was superior to serology at detecting gastric atrophy: NBI-Z gastric atrophy 0.88(95%CI 0.81-0.94) vs PGI/II ratio
Citation
White, J. R., Sami, S. S., Reddiar, D., Mannath, J., Ortiz Fernández-Sordo, J., Beg, S., Scott, R., Thiagarajan, P., Ahmad, S., Parra-Blanco, A., Kasi, M., Telakis, E., Sultan, A. A., Davis, J., Figgins, A., Kaye, P., Robinson, K., Atherton, J. C., & Ragunath, K. (2019). Narrow band imaging and serology in the assessment of premalignant gastric pathology. Scandinavian Journal of Gastroenterology, 53(12), 1611-1618. https://doi.org/10.1080/00365521.2018.1542455
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 23, 2018 |
Online Publication Date | Jan 2, 2019 |
Publication Date | Jan 2, 2019 |
Deposit Date | Jan 10, 2019 |
Publicly Available Date | Jan 3, 2020 |
Journal | Scandinavian Journal of Gastroenterology |
Print ISSN | 0036-5521 |
Electronic ISSN | 1502-7708 |
Publisher | Taylor and Francis |
Peer Reviewed | Peer Reviewed |
Volume | 53 |
Issue | 12 |
Pages | 1611-1618 |
DOI | https://doi.org/10.1080/00365521.2018.1542455 |
Keywords | Endoscopy, narrow band imaging, white light endoscopy, serology, H. pylori gastritis, gastric atrophy, intestinal metaplasia |
Public URL | https://nottingham-repository.worktribe.com/output/1459417 |
Publisher URL | https://www.tandfonline.com/doi/full/10.1080/00365521.2018.1542455 |
Additional Information | This is an Accepted Manuscript of an article published by Taylor & Francis in Scandinavian Journal of Gastroenterology on 2 Jan 2019, available online: http://www.tandfonline.com/10.1080/00365521.2018.1542455. Corresponding author: Jonathan R White Corresponding author email: jonathan.white@nottingham.ac.uk |
Contract Date | Jan 10, 2019 |
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