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All Outputs (52)

‘Blood in pee’ campaign: Increased demand on secondary care with no change in cancers diagnosed (2018)
Journal Article
Patel, K., Hall, S. J., Shraddha, K., Stanford, R., Williams, S., & Lund, J. (2019). ‘Blood in pee’ campaign: Increased demand on secondary care with no change in cancers diagnosed. Journal of Clinical Urology, 12(1), 15-19. https://doi.org/10.1177/2051415818801187

Objective:
As part of the national Be Clear on Cancer campaign, the ‘blood in pee’ campaign was launched in 2013. We aimed to evaluate the impact of the campaign on 2-week wait (2WW) referrals and the resulting diagnoses of malignancy at a single tr... Read More about ‘Blood in pee’ campaign: Increased demand on secondary care with no change in cancers diagnosed.

Fibrin glue obliteration is safe, effective and minimally invasive as first line treatment for pilonidal sinus disease in children (2018)
Journal Article
Hardy, E., Herrod, P., Sian, T., Boyd-Carson, H., Blackwell, J., Lund, J., & Quarmby, J. (2019). Fibrin glue obliteration is safe, effective and minimally invasive as first line treatment for pilonidal sinus disease in children. Journal of Pediatric Surgery, 54(8), 1668-1670. https://doi.org/10.1016/j.jpedsurg.2018.07.024

Background / Purpose: Sacrococcygeal pilonidal sinus disease (PSD) has an incidence of 1.2–2.5/1000 in children. Onset is around puberty. Symptoms of recurrent abscess and chronic suppuration may interfere with education and social integration. Treat... Read More about Fibrin glue obliteration is safe, effective and minimally invasive as first line treatment for pilonidal sinus disease in children.

The use of cannabinoids in colitis: a systematic review and meta-analysis (2018)
Journal Article
Couch, D. G., Maudslay, H., Doleman, B., Lund, J. N., & O'Sullivan, S. (2018). The use of cannabinoids in colitis: a systematic review and meta-analysis. Inflammatory Bowel Diseases, 24(4), 680-697. https://doi.org/10.1093/ibd/izy014

Background: Clinical trials investigating the use of cannabinoid drugs for the treatment of intestinal inflammation are anticipated secondary to preclinical literature demonstrating efficacy in reducing inflammation.
Methods: We systematically revie... Read More about The use of cannabinoids in colitis: a systematic review and meta-analysis.

Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery (Protocol) (2018)
Journal Article
Doleman, B., Leonardi-Bee, J., Heinink, T. P., Lund, J., & Williams, J. P. (2018). Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery (Protocol). Cochrane Database of Systematic Reviews, 3, https://doi.org/10.1002/14651858.CD012978

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To evaluate in adult participants undergoing all types of surgery, the effects of pre-emptive and preventive non-steroidal anti-inflammatory drugs (NSAIDs) com... Read More about Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery (Protocol).

A multicentre integration of a computer-led follow-up of prostate cancer is valid and safe (2018)
Journal Article
Salem, H. A., Salem, H. A., Caddeo, G., McFarlane, J., Patel, K., Cochrane, L., …Lund, J. (2018). A multicentre integration of a computer-led follow-up of prostate cancer is valid and safe. BJU International, 122(3), 418-426. https://doi.org/10.1111/bju.14157

© 2018 The Authors BJU International published by John Wiley & Sons Ltd on behalf of BJU International Objective: To test a computer-led follow-up service for prostate cancer in two UK hospitals; the testing aimed to validate the computer expert sy... Read More about A multicentre integration of a computer-led follow-up of prostate cancer is valid and safe.

Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost‑efective and should be replaced with universally performed pre‑endoscopy serology in patients on a suspected cancer pathway (2018)
Journal Article
Herrod, P., & Lund, J. N. (in press). Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost‑efective and should be replaced with universally performed pre‑endoscopy serology in patients on a suspected cancer pathway. Techniques in Coloproctology, 22(2), https://doi.org/10.1007/s10151-018-1756-7

Background: Random duodenal biopsy to exclude coeliac disease during upper gastrointestinal endoscopy for the investigation of iron defciency anaemia remains a common procedure, but is expensive and time-consuming. Serological investigation for coeli... Read More about Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost‑efective and should be replaced with universally performed pre‑endoscopy serology in patients on a suspected cancer pathway.

NICE guidance on sepsis is of limited value in postoperative colorectal patients: the scores that cry ‘wolf!’ (2018)
Journal Article
Herrod, P., Cox, M., Keevil, H., Smith, K., & Lund, J. N. (2018). NICE guidance on sepsis is of limited value in postoperative colorectal patients: the scores that cry ‘wolf!’. Annals of The Royal College of Surgeons of England, 100(4), 275-278. https://doi.org/10.1308/rcsann.2017.0227

Background and aims
Late recognition of sepsis and consequent death remains a problem. To address this, the National Institute for Health and Care Excellence has published updated guidance recommending the use of the Quick Sequential Organ Failure A... Read More about NICE guidance on sepsis is of limited value in postoperative colorectal patients: the scores that cry ‘wolf!’.

Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men (2017)
Journal Article
Mitchell, W. K., Phillips, B. E., Hill, I., Greenhaff, P. L., Lund, J. N., Williams, J. P., …Atherton, P. J. (2017). Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men. Clinical Science, 131(21), https://doi.org/10.1042/CS20171230

Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a “muscle-full” state. However, the e... Read More about Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.

Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon (2017)
Journal Article
Couch, D. G., Tasker, C., Theophilidou, E., Lund, J. N., & O'Sullivan, S. (2017). Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon. Clinical Science, 131(21), https://doi.org/10.1042/CS20171288

Objective: We sought to quantify the anti-inflammatory effects of two cannabinoid drugs, cannabidiol (CBD) and palmitoylethanolamide (PEA), in cultured cell lines and compared this effect with experimentally inflamed explant human colonic tissue. The... Read More about Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon.

DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease (2017)
Journal Article
Jeziorska, D. M., Murray, R. J. S., De Gobbi, M., Gaentzsch, R., Garrick, D., Ayyub, H., …Tufarelli, C. (2017). DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease. Proceedings of the National Academy of Sciences, 114(36), E7526-E7535. https://doi.org/10.1073/pnas.1703087114

The human genome contains ∼30,000 CpG islands (CGIs). While CGIs associated with promoters nearly always remain unmethylated, many of the ∼9,000 CGIs lying within gene bodies become methylated during development and differentiation. Both promoter and... Read More about DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease.

A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle (2017)
Journal Article
Brook, M. S., Wilkinson, D., Mitchell, W. K., Lund, J. N., Phillips, B. E., Szewczyk, N. J., …Atherton, P. J. (2017). A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle. AJP - Endocrinology and Metabolism, 313(6), Article E681-E689. https://doi.org/10.1152/ajpendo.00157.2017

Current methods to quantify in vivo RNA dynamics are limited. Here, we developed a novel stable isotope (D2O) methodology to quantify RNA synthesis (i.e., ribosomal biogenesis) in cells, animal models, and humans. First, proliferating C2C12 cells wer... Read More about A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle.

Robotic colorectal surgery: previous laparoscopic colorectal experience is not essential (2017)
Journal Article
Sian, T. S., Tierney, G. M., Park, H., Lund, J. N., Speake, W. J., Hurst, N. G., …Tou, S. (2018). Robotic colorectal surgery: previous laparoscopic colorectal experience is not essential. Journal of Robotic Surgery, 12(2), 271-275. https://doi.org/10.1007/s11701-017-0728-7

A background in minimally invasive colorectal surgery (MICS) has been thought to be essential prior to robotic-assisted colorectal surgery (RACS). Our aim was to determine whether MICS is essential prior to starting RACS training based on results fro... Read More about Robotic colorectal surgery: previous laparoscopic colorectal experience is not essential.

Baseline morphine consumption may explain between-study heterogeneity in meta-analyses of adjuvant analgesics and improve precision and accuracy of effect estimates (2017)
Journal Article
Doleman, B., Sutton, A. J., Sherwin, M., Lund, J. N., & Williams, J. P. (2018). Baseline morphine consumption may explain between-study heterogeneity in meta-analyses of adjuvant analgesics and improve precision and accuracy of effect estimates. Anesthesia and Analgesia, 126(2), 648-660. https://doi.org/10.1213/ANE.0000000000002237

BACKGROUND: Statistical heterogeneity can increase the uncertainty of results and reduce the quality of evidence derived from systematic reviews. At present, it is uncertain what the major factors are that account for heterogeneity in meta-analyses o... Read More about Baseline morphine consumption may explain between-study heterogeneity in meta-analyses of adjuvant analgesics and improve precision and accuracy of effect estimates.

Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer (2017)
Journal Article
Vafadar-Isfahani, N., Parr, C., McMillan, L. E., Sanner, J., Yeo, Z., Saddington, S., …Tufarelli, C. (2017). Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer. Epigenetics, 12(6), 465-475. https://doi.org/10.1080/15592294.2017.1300729

Hypomethylation of LINE-1 repeats in cancer has been proposed as the main mechanism behind their activation; this assumption, however, was based on findings from early studies that were biased toward young and transpositionally active elements. Here,... Read More about Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer.

Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers (2017)
Journal Article
Heinink, T. P., Read, D. J., Mitchell, W. K., Bhalla, A., Lund, J. N., Phillips, B. E., & Williams, J. P. (2018). Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers. Clinical Physiology and Functional Imaging, 38(2), 213-219. https://doi.org/10.1111/cpf.12401

Background

Oesophageal Doppler monitoring (ODM) is used clinically to optimize cardiac output (CO) and guide fluid therapy. Despite limited experimental evidence, it is assumed that increasing CO increases visceral microvascular blood flow (MBF).... Read More about Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers.

Fibrin glue for pilonidal sinus disease (2017)
Journal Article
Lund, J. N., Tou, S., Doleman, B., & Williams, J. P. (in press). Fibrin glue for pilonidal sinus disease. Cochrane Database of Systematic Reviews, 2017(1), Article CD011923. https://doi.org/10.1002/14651858.CD011923.pub2

Background
Pilonidal sinus disease is a common condition that mainly affects young adults. This condition can cause significant pain and impairment of normal activities. No consensus currently exists on the optimum treatment for pilonidal sinus and... Read More about Fibrin glue for pilonidal sinus disease.

Simulation fails to replicate stress in trainees performing a technical procedure in the clinical environment (2016)
Journal Article
Baker, B., Bhalla, A., Doleman, B., Yarnold, E., Simons, S., Lund, J. N., & Williams, J. P. (in press). Simulation fails to replicate stress in trainees performing a technical procedure in the clinical environment. Medical Teacher, 39(1), https://doi.org/10.1080/0142159X.2016.1230188

Introduction: Simulation-based training (SBT) has become an increasingly important method by which doctors learn. Stress has an impact upon learning, performance, technical, and non-technical skills. However, there are currently no studies that compa... Read More about Simulation fails to replicate stress in trainees performing a technical procedure in the clinical environment.

Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition (2016)
Journal Article
Mitchell, W. K., Wilkinson, D. J., Phillips, B. E., Lund, J. N., Smith, K., & Atherton, P. J. (2016). Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition. Advances in Nutrition, 7(4), 828S-838S. https://doi.org/10.3945/an.115.011650

Healthy individuals maintain remarkably constant skeletal muscle mass across much of adult life, suggesting the existence of robust homeostatic mechanisms. Muscle exists in dynamic equilibrium whereby the influx of amino acids (AAs) and the resulting... Read More about Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition.