Research Repository

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Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea (2018)
Journal Article
Laviola, M., Das, A., Chikhani, M., Bates, D., & Hardman, J. (2019). Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea. British Journal of Anaesthesia, 122(3), 395-401. doi:10.1016/j.bja.2018.11.012

Background Apnoeic oxygenation can come close to matching the oxygen demands of the apnoeic patient but does not facilitate carbon dioxide (CO2) elimination, potentially resulting in dangerous hypercapnia. Numerous studies have shown that high-flo... Read More

Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score (2018)
Journal Article
Sinha, R., Correia, R., Gardner, D., Grau-Roma, L., de Brot, S., Hardman, J., …Norris, A. (2018). Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score. Laryngoscope Investigative Otolaryngology, doi:10.1002/lio2.168. ISSN 2378-8038

Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed... Read More

An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation (2018)
Journal Article
Saffaran, S., Wang, W., Das, A., Schmitt, W., Becker-Pelster, E., Hardman, J. G., …Bates, D. G. (in press). An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation. CPT: Pharmacometrics and Systems Pharmacology, doi:10.1002/psp4.12308. ISSN 2163-8306

This study uses a highly fidelity computational simulator of pulmonary physiology to evaluate the impact of a soluble guanylate cyclase (sGC) modulator on gas exchange in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypert... Read More

Cohort study of preoperative blood pressure and risk of 30-day mortality after elective non-cardiac surgery (2017)
Journal Article
Venkatesan, S., Myles, P., Hardman, J., Manning, H., Mozid, A., Andersson, C., …Sanders, R. (2017). Cohort study of preoperative blood pressure and risk of 30-day mortality after elective non-cardiac surgery. British Journal of Anaesthesia, 119(1), 65-77. doi:10.1093/bja/aex056

Background Preoperative blood pressure (BP) thresholds associated with increased postoperative mortality remain unclear. We investigated the relationship between preoperative BP and 30-day mortality after elective non-cardiac surgery. Methods... Read More

Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome (2017)
Journal Article
Das, A., Haque, M., Chikhani, M., Cole, O., Wang, W., Hardman, J. G., & Bates, D. G. (2017). Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome. BMC Pulmonary Medicine, 17(34), doi:10.1186/s12890-017-0369-7. ISSN 1471-2466

Background: Clinical trials have, so far, failed to establish clear beneficial outcomes of recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome (ARDS), and the effects of RMs on the cardiovascular system remain poor... Read More

Visuospatial ability as a predictor of novice performance in ultrasound–guided regional anesthesia (2015)
Journal Article
Atif, S., Ferguson, E., Thanawala, V., Bedforth, N. M., Hardman, J., & McCahon, R. A. (2015). Visuospatial ability as a predictor of novice performance in ultrasound–guided regional anesthesia. Anesthesiology, 123(5), doi:10.1097/ALN.0000000000000870

Background: Visuospatial ability correlates positively with novice performance of simple laparoscopic tasks. The aims of this study were to identify if visuospatial ability could predict technical performance of an ultrasound–guided needle task by n... Read More

Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation (2015)
Journal Article
Das, A., Cole, O., Chikhani, M., Wang, W., Ali, T., Haque, M., …Hardman, J. G. (2015). Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation. Critical Care, 19, doi:10.1186/s13054-014-0723-6

Introduction: Direct comparison of the relative efficacy of different recruitment maneuvers (RMs) for patients with acute respiratory distress syndrome (ARDS) via clinical trials is difficult, due to the heterogeneity of patient populations and disea... Read More

Cost effectiveness of epidural steroid injections to manage chronic lower back pain (2012)
Journal Article
Whynes, D. K., McCahon, R. A., Ravenscroft, A., & Hardman, J. (2012). Cost effectiveness of epidural steroid injections to manage chronic lower back pain. BMC Anesthesiology, 12(26), doi:10.1186/1471-2253-12-26. ISSN 1471-2253

Background The efficacy of epidural steroid injections in the management of chronic low back pain is disputed, yet the technique remains popular amongst physicians and patients alike. This study assesses the cost effectiveness of injections administ... Read More