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Correction: Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain (PLoS ONE 12:2: (e0172724) DOI: 10.1371/journal.pone.0172724) (2017)
Journal Article
Lewis, J. E., Brameld, J. M., Hill, P., Cocco, C., Noli, B., Ferri, G. L., …Jethwa, P. H. (2017). Correction: Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain (PLoS ONE 12:2: (e0172724) DOI: 10.1371/journal.pone.0172724). PLoS ONE, 12(7), https://doi.org/10.1371/journal.pone.0182594

© 2017 Lewis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cred... Read More about Correction: Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain (PLoS ONE 12:2: (e0172724) DOI: 10.1371/journal.pone.0172724).

Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women (2017)
Journal Article
Alshammari, G., Khan, R., Brameld, J. M., Amer, S. A., & Lomax, M. A. (2017). Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women. European Review for Medical and Pharmacological Sciences, 21(5),

OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory m... Read More about Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women.

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth (2016)
Journal Article
Brown, D. M., Williams, H., Ryan, K., Wilson, T., Daniel, Z. C., Mareko, M. H. D., Emes, R. D., Harris, D. W., Wattis, J. A., Dryden, I. L., Hodgman, T. C., Brameld, J. M., & Parr, T. (2016). Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth. Scientific Reports, 6(1), https://doi.org/10.1038/srep28693

We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20ppm in feed) or Reporcin (recombin... Read More about Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth.

Improving efficiency in meat production (2016)
Journal Article
Brameld, J. M., & Parr, T. (in press). Improving efficiency in meat production. Proceedings of the Nutrition Society, https://doi.org/10.1017/S0029665116000161

Selective breeding and improved nutritional management over the past 20–30 years has resulted in dramatic improvements in growth efficiency for pigs and poultry, particularly lean tissue growth. However, this has been achieved using high-quality feed... Read More about Improving efficiency in meat production.

Thyroid hormone and vitamin D regulate VGF expression and promoter activity (2016)
Journal Article
Lewis, J. E., Brameld, J. M., Hill, P., Wilson, D., Barrett, P., Ebling, F. J., & Jethwa, P. H. (2016). Thyroid hormone and vitamin D regulate VGF expression and promoter activity. Journal of Molecular Endocrinology, 56(2), 123-134. https://doi.org/10.1530/JME-15-0224

The Siberian hamster (Phodopus sungorus) survives winter by decreasing food intake and catabolizing abdominal fat reserves, resulting in a sustained, profound loss of body weight. Hypothalamic tanycytes are pivotal for this process. In these cells, s... Read More about Thyroid hormone and vitamin D regulate VGF expression and promoter activity.

Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential Residual Feed Intake in pigs (2015)
Journal Article
Jing, L., Wu, H., Miao, Y., Cao, J., Brameld, J. M., Parr, T., & Zhao, S. (2015). Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential Residual Feed Intake in pigs. Scientific Reports, 5, Article 11953. https://doi.org/10.1038/srep11953

Feed efficiency (FE) can be measured by feed conversion ratio (FCR) or residual feed intake (RFI). In this study, we measured the FE related phenotypes of 236 castrated purebred Yorkshire boars, and selected 10 extreme individuals with high and low R... Read More about Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential Residual Feed Intake in pigs.

Differential effects of short-term β agonist and growth hormone treatments on expression of myosin heavy chain IIB and associated metabolic genes in sheep muscle (2014)
Journal Article
Hemmings, K. M., Daniel, Z. C., Buttery, P. J., Parr, T., & Brameld, J. M. (2015). Differential effects of short-term β agonist and growth hormone treatments on expression of myosin heavy chain IIB and associated metabolic genes in sheep muscle. Animal, 9(2), 285-294. https://doi.org/10.1017/s175173111400233x

Growth hormone (GH) and β agonists increase muscle mass, but the mechanisms for this response are unclear and the magnitude of response is thought to vary with age of animal. To investigate the mechanisms driving the muscle response to these agents,... Read More about Differential effects of short-term β agonist and growth hormone treatments on expression of myosin heavy chain IIB and associated metabolic genes in sheep muscle.

Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to adipose cells (2013)
Journal Article
Ryan, K. J., Daniel, Z. C., Craggs, L. J., Parr, T., & Brameld, J. M. (2013). Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to adipose cells. Journal of Endocrinology, 217(1), 45-58. https://doi.org/10.1530/JOE-12-0234

Fat infiltration within muscle is one of a number of features of vitamin D deficiency, which leads to a decline in muscle functionality. The origin of this fat is unclear, but one possibility is that it forms from myogenic precursor cells present in... Read More about Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to adipose cells.

Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity (2012)
Journal Article
Murphy, M., Samms, R., Warner, A., Bolborea, M., Barrett, P., Fowler, M. J., …Ebling, F. J. (2013). Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity. Journal of Neuroendocrinology, 25(2), 180-189. https://doi.org/10.1111/j.1365-2826.2012.02383.x

The present study aimed to investigate the actions of fibroblast growth factor 21 (FGF21) on energy balance in a natural model of relative fatness, the Siberian hamster. Hamsters were studied under long days (LD) to promote weight gain, or short days... Read More about Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity.

Effects of manipulating hypothalamic triiodothyronine concentrations on seasonal body weight and torpor cycles in Siberian hamsters (2012)
Journal Article
Murphy, M., Jethwa, P. H., Warner, A., Barrett, P., Nilaweera, K. N., Brameld, J. M., & Ebling, F. J. (2012). Effects of manipulating hypothalamic triiodothyronine concentrations on seasonal body weight and torpor cycles in Siberian hamsters. Endocrinology, 153(1), 101-112. https://doi.org/10.1210/en.2011-1249

Siberian hamsters display photoperiodically regulated annual cycles in body weight, appetite, and reproduction. Previous studies have revealed a profound up-regulation of type 3 deiodinase (DIO3) mRNA in the ventral ependyma of the hypothalamus assoc... Read More about Effects of manipulating hypothalamic triiodothyronine concentrations on seasonal body weight and torpor cycles in Siberian hamsters.

Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis (2011)
Journal Article
Brown, D. M., Parr, T., & Brameld, J. M. (2012). Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis. Journal of Muscle Research and Cell Motility, 32(6), 383-390. https://doi.org/10.1007/s10974-011-9267-4

The regulation of muscle fibre transitions has mainly been studied in vivo using conventional histological or immunohistochemical techniques. In order to investigate the molecular regulation of myosin heavy chain (MyHC) isoform expression in cell cul... Read More about Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis.

Regional variation in angiotensin converting enzyme activity in the human placenta (2011)
Journal Article
Brameld, J. M., Hold, R., & Broughton Pipkin, F. (2011). Regional variation in angiotensin converting enzyme activity in the human placenta. Placenta, 32(11), 906-908. https://doi.org/10.1016/j.placenta.2011.07.085

Sensitivity of chorionic plate arteries to angiotensin II (AngII) is greatest at the placental periphery. Angiotensin converting enzyme (ACE) is central to the synthesis of AngII and is present in the placental vasculature. We measured vascular ACE a... Read More about Regional variation in angiotensin converting enzyme activity in the human placenta.

Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes (2011)
Journal Article
Graham, N. S., May, S. T., Daniel, Z. C., Emmerson, Z. F., Brameld, J. M., & Parr, T. (2011). Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes. Animal, 5(6), 861-866. https://doi.org/10.1017/S1751731110002533

Affymetrix GeneChip microarrays are a powerful tool to study global gene expression profiles and have been used on many species. However, no sheep-specific Affymetrix GeneChip is currently available and the bovine array is fairly limited in its cover... Read More about Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes.

Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. I. Regulation of myogenesis and environmental impact (2011)
Journal Article
Rehfeldt, C., Te Pas, M. F., Wimmers, K., Brameld, J. M., Nissen, P. M., Berri, C., …Oksbjerg, N. (2011). Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. I. Regulation of myogenesis and environmental impact. Animal, 5(5), 703-717. https://doi.org/10.1017/S1751731110002089

Skeletal muscle development in vertebrates - also termed myogenesis - is a highly integrated process. Evidence to date indicates that the processes are very similar across mammals, poultry and fish, although the timings of the various steps differ co... Read More about Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. I. Regulation of myogenesis and environmental impact.

Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. II - Genetic factors related to animal performance and advances in methodology (2011)
Journal Article
Rehfeldt, C., Te Pas, M. F., Wimmers, K., Brameld, J. M., Nissen, P. M., Berri, C., …Oksbjerg, N. (2011). Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. II - Genetic factors related to animal performance and advances in methodology. Animal, 5(5), 718-730. https://doi.org/10.1017/S1751731110002454

Selective breeding is an effective tool to improve livestock. Several selection experiments have been conducted to study direct selection responses as well as correlated responses in traits of skeletal muscle growth and function. Moreover, comparison... Read More about Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. II - Genetic factors related to animal performance and advances in methodology.

Biological mechanisms of fetal development relating to postnatal growth, efficiency and carcass characteristics in ruminants (2010)
Book Chapter
Brameld, J. M., Greenwood, P. L., & Bell, A. W. (2010). Biological mechanisms of fetal development relating to postnatal growth, efficiency and carcass characteristics in ruminants. In P. L. Greenwood, A. W. Bell, P. E. Vercoe, & G. J. Viljoen (Eds.), Managing the Prenatal Environment to Enhance Livestock Productivity (93-119). Springer Publishing Company. https://doi.org/10.1007/978-90-481-3135-8_4

Copyright © International Atomic Energy Agency 2010. All Rights Reserved. Over recent years there has been a lot of interest in the effects of prenatal environment on subsequent development of tissues and the postnatal consequences. In farm animal sp... Read More about Biological mechanisms of fetal development relating to postnatal growth, efficiency and carcass characteristics in ruminants.

Effects of photoperiod on daily locomotor activity, energy expenditure, and feeding behavior in a seasonal mammal (2010)
Journal Article
Warner, A., Jethwa, P. H., Wyse, C. A., I'Anson, H., Brameld, J. M., & Ebling, F. J. (2010). Effects of photoperiod on daily locomotor activity, energy expenditure, and feeding behavior in a seasonal mammal. AJP - Regulatory, Integrative and Comparative Physiology, 298(5), R1409-R1416. https://doi.org/10.1152/ajpregu.00279.2009

The objective of this study was to determine whether the previously observed effects of photoperiod on body weight in Siberian hamsters were due to changes in the daily patterns of locomotor activity, energy expenditure, and/or feeding behavior. Adul... Read More about Effects of photoperiod on daily locomotor activity, energy expenditure, and feeding behavior in a seasonal mammal.