Regional variation in angiotensin converting enzyme activity in the human placenta

Brameld, J. M.; Hold, R.; Broughton Pipkin, F.

Abstract

Sensitivity of chorionic plate arteries to angiotensin II (AngII) is greatest at the placental periphery. Angiotensin converting enzyme (ACE) is central to the synthesis of AngII and is present in the placental vasculature. We measured vascular ACE activity/mg protein at 8-9 sites between the cord insertion and the periphery in 12 term placentae from normotensive, vaginally-delivered women. ACE increased from insertion to the periphery (P = 0.015); median ACE for each placenta was positively correlated with placental weight (P < 0.05) and placental:birthweight ratio (P < 0.02). We speculate that this may be related to fetal programming since placental:birthweight ratio is related to long-term health. © 2011 Elsevier Ltd. All rights reserved.

Citation

Brameld, J. M., Hold, R., & Broughton Pipkin, F. (2011). Regional variation in angiotensin converting enzyme activity in the human placenta. Placenta, 32(11), 906-908. https://doi.org/10.1016/j.placenta.2011.07.085

• Journal Article Type: Article
• Acceptance Date: Jul 27, 2011
• Online Publication Date: Sep 8, 2011
• Publication Date: 2011-11
• Deposit Date: Feb 9, 2021
• Journal: Placenta
• Print ISSN: 0143-4004
• Electronic ISSN: 1532-3102
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 32
• Issue: 11
• Pages: 906-908
• DOI: https://doi.org/10.1016/j.placenta.2011.07.085
• Public URL: https://nottingham-repository.worktribe.com/output/3185826
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S0143400411003742