Skip to main content

Research Repository

Advanced Search

All Outputs (58)

Endocannabinoids in aqueous humour of patients with or without diabetes (2020)
Journal Article
Richardson, P. S., Ortori, C., Barrett, D. A., O'Sullivan, S. E., & Idris, I. (2020). Endocannabinoids in aqueous humour of patients with or without diabetes. BMJ Open Ophthalmology, 5(1), Article e000425. https://doi.org/10.1136/bmjophth-2019-000425

Objective The primary aim was to determine endocannabinoid (EC) concentrations of 2-arachidonoylglycerol (2-AG), oleoylethanolamine (OEA), palmitoylethanolamine (PEA) and anandamide (AEA) in the aqueous humour of patients, and to investigate any diff... Read More about Endocannabinoids in aqueous humour of patients with or without diabetes.

Clinical characteristics and patient treatment satisfaction with Humalog U-200 in patients with type 2 diabetes mellitus: an observational study (2019)
Journal Article
Mamza, J., Anyanwagu, U., Alkharaiji, M., & Idris, I. (2020). Clinical characteristics and patient treatment satisfaction with Humalog U-200 in patients with type 2 diabetes mellitus: an observational study. Journal of Drug Assessment, 9(1), 8-12. https://doi.org/10.1080/21556660.2019.1704415

Background There is limited data on the real world evidence of Humalog 200 units/ml KwikPen (U-200) insulin. We assessed the use of U-200 insulin in UK routine clinical practice to provide information on clinical characteristics, treatment satisfacti... Read More about Clinical characteristics and patient treatment satisfaction with Humalog U-200 in patients with type 2 diabetes mellitus: an observational study.

Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men (2019)
Journal Article
Gharahdaghi, N., Rudrappa, S., Brook, M. S., Idris, I., Crossland, H., Hamrock, C., Aziz, H., Kadi, F., Tarum, J., Greenhaff, P. L., Constantin‐Teodosiu, D., Cegielski, J., Phillips, B. E., Wilkinson, D. J., Szewczyk, N. J., Smith, K., & Atherton, P. J. (2019). Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men. Journal of Cachexia, Sarcopenia and Muscle, 10(6), 1276-1294. https://doi.org/10.1002/jcsm.12472

Background: The andropause is associated with declines in serum testosterone (T), loss of muscle mass (sarcopenia) and frailty. Two major interventions purported to offset sarcopenia are anabolic steroid therapies and resistance exercise training (RE... Read More about Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men.

Effect of Bariatric Surgery on Cardiovascular Events and Metabolic Outcomes in Obese Patients with Insulin-Treated Type 2 Diabetes: a Retrospective Cohort Study (2019)
Journal Article
Alkharaiji, M., Anyanwagu, U., Donnelly, R., & Idris, I. (2019). Effect of Bariatric Surgery on Cardiovascular Events and Metabolic Outcomes in Obese Patients with Insulin-Treated Type 2 Diabetes: a Retrospective Cohort Study. Obesity Surgery, 29(10), 3154-3164. https://doi.org/10.1007/s11695-019-03809-4

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Aims: To compare non-fatal cardiovascular (CV) events and metabolic outcomes, among obese patients with insulin-treated type 2 diabetes who underwent bariatric surgery compared wi... Read More about Effect of Bariatric Surgery on Cardiovascular Events and Metabolic Outcomes in Obese Patients with Insulin-Treated Type 2 Diabetes: a Retrospective Cohort Study.

The effect of oral essential amino acids on incretin hormone production in youth and ageing (2019)
Journal Article
Abdulla, H., Bass, J., Stokes, T., Gorissen, S., McGlory, C., Phillips, B., Phillips, S., Smith, K., Idris, I., & Atherton, P. (2019). The effect of oral essential amino acids on incretin hormone production in youth and ageing. Endocrinology, Diabetes and Metabolism, 2(4), Article e00085. https://doi.org/10.1002/edm2.85

Background
The effect of substantive doses of essential amino acids (EAA) on incretin and insulin production, and the impact of age upon this effect, is ill‐defined.

Methods
A 15‐g oral EAA drink was administered to young (N = 8; 26 ± 4.4 years)... Read More about The effect of oral essential amino acids on incretin hormone production in youth and ageing.

Efficacy and Safety of Pioglitazone Monotherapy in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials (2019)
Journal Article
Alam, F., Islam, M. A., Mohamed, M., Ahmad, I., Kamal, M. A., Donnelly, R., Idris, I., & Gan, S. H. (2019). Efficacy and Safety of Pioglitazone Monotherapy in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Scientific Reports, 9, Article 5389. https://doi.org/10.1038/s41598-019-41854-2

Pioglitazone, the only thiazolidinedione drug in clinical practice is under scrutiny due to reported adverse effects, it’s unique insulin sensitising action provides rationale to remain as a therapeutic option for managing type 2 diabetes mellitus (T... Read More about Efficacy and Safety of Pioglitazone Monotherapy in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Albuminuria regression and all-cause mortality among insulin-treated patients with Type 2 diabetes: analysis of a large UK Primary Care cohort (2019)
Journal Article
Anyanwagu, U., Donnelly, R., & Idris, I. (2019). Albuminuria regression and all-cause mortality among insulin-treated patients with Type 2 diabetes: analysis of a large UK Primary Care cohort. American Journal of Nephrology, 49(2), 146-155. https://doi.org/10.1159/000496276

Background: Overt albuminuria (urinary albumin-creatinine ratio (ACR) >300mg/g) is an established risk factor for progression of nephropathy and total mortality. However, whether, a reduction in ACR translates into a reduction in mortality and/or car... Read More about Albuminuria regression and all-cause mortality among insulin-treated patients with Type 2 diabetes: analysis of a large UK Primary Care cohort.

Individual and combined relationship between reduced eGFR and/or increased urinary albumin excretion rate with mortality risk among insulin treated patients with Type 2 diabetes in routine practice (2018)
Journal Article
Anyanwagu, U., Donnelly, R., & Idris, I. (2019). Individual and combined relationship between reduced eGFR and/or increased urinary albumin excretion rate with mortality risk among insulin treated patients with Type 2 diabetes in routine practice. Kidney Diseases, 5(2), 91–99. https://doi.org/10.1159/000493731

Background: Low estimated glomerular filtration rate (eGFR) and increased urinary albumin-to-creatinine ratio (ACR) are well-recognised prognostic markers of cardiovascular (CV) risk, but their individual and combine relationship with CV disease and... Read More about Individual and combined relationship between reduced eGFR and/or increased urinary albumin excretion rate with mortality risk among insulin treated patients with Type 2 diabetes in routine practice.

Tier 3 specialist weight management service and pre-bariatric multicomponent weight management programmes for adults with obesity living in the UK: a systemic review (2018)
Journal Article
Alkharaiji, M., Anyanwagu, U., Donnelly, R., & Idris, I. (2019). Tier 3 specialist weight management service and pre-bariatric multicomponent weight management programmes for adults with obesity living in the UK: a systemic review. Endocrinology, Diabetes and Metabolism, 2(1), Article e00042. https://doi.org/10.1002/edm2.42

Background: NHS England has recommended a multidisciplinary weight management services (MWMS -Tier 3 services) for patients requiring specialised management of obesity, including bariatric surgery, but clinical and measurable health-related outcomes... Read More about Tier 3 specialist weight management service and pre-bariatric multicomponent weight management programmes for adults with obesity living in the UK: a systemic review.

Short-Term Impact of Bariatric Surgery on Best-Corrected Distance Visual Acuity and Diabetic Retinopathy Progression (2018)
Journal Article
Richardson, P., Hulpus, A., & Idris, I. (2018). Short-Term Impact of Bariatric Surgery on Best-Corrected Distance Visual Acuity and Diabetic Retinopathy Progression. Obesity Surgery, 28(11), 3711-3713. https://doi.org/10.1007/s11695-018-3445-z

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. The immediate impact of rapid glucose lowering induced by bariatric surgery on diabetic retinopathy (DR) progression remains unclear. We present 3-year changes in the best-correct... Read More about Short-Term Impact of Bariatric Surgery on Best-Corrected Distance Visual Acuity and Diabetic Retinopathy Progression.

The relationship between urinary albumin excretion, cardiovascular outcomes and total mortality among a large cohort of insulin-treated patients with type 2 diabetes in routine primary care practices (2018)
Journal Article
Anyanwagu, U., Donnelly, R., & Idris, I. (2020). The relationship between urinary albumin excretion, cardiovascular outcomes and total mortality among a large cohort of insulin-treated patients with type 2 diabetes in routine primary care practices. Nephrology Dialysis Transplantation, 35(3), 471-477. https://doi.org/10.1093/ndt/gfy258

© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. BACKGROUND: Albuminuria is a recognized diagnostic and prognostic marker of chronic kidney disease and cardiovascular (CV) risk but the well-known... Read More about The relationship between urinary albumin excretion, cardiovascular outcomes and total mortality among a large cohort of insulin-treated patients with type 2 diabetes in routine primary care practices.

Genetic polymorphisms of the endocannabinoid system in obesity and diabetes (2018)
Journal Article
Doris, J. M., Millar, S. A., Idris, I., & O'Sullivan, S. E. (2019). Genetic polymorphisms of the endocannabinoid system in obesity and diabetes. Diabetes, Obesity and Metabolism, 21(2), 382-387. https://doi.org/10.1111/dom.13504

The endocannabinoid system (ECS) is involved in many physiological processes including fertility, pain and energy regulation. The aim of this systematic review was to examine the contribution of single nucleotide polymorphisms (SNPs) of the ECS to ad... Read More about Genetic polymorphisms of the endocannabinoid system in obesity and diabetes.

Treatment choice, medication adherence and glycemic efficacy in people with type 2 diabetes: a UK clinical practice database study (2018)
Journal Article
Gordon, J., McEwan, P., Idris, I., Evans, M., & Puelles, J. (2018). Treatment choice, medication adherence and glycemic efficacy in people with type 2 diabetes: a UK clinical practice database study. BMJ Open Diabetes Research and Care, 6(1), Article e000512. https://doi.org/10.1136/bmjdrc-2018-000512

Objective

Using primary care data obtained from the UK Clinical Practice Research Datalink, this retrospective cohort study examined the relationships between medication adherence and clinical outcomes in patients with type 2 diabetes.

Researc... Read More about Treatment choice, medication adherence and glycemic efficacy in people with type 2 diabetes: a UK clinical practice database study.

Effects of obesity on metabolic and cardiovascular outcomes following insulin initiation in patients with type 2 diabetes (2017)
Journal Article
Anyanwagu, U., Mamza, J., Donnelly, R., & Idris, I. (2018). Effects of obesity on metabolic and cardiovascular outcomes following insulin initiation in patients with type 2 diabetes. Obesity Research and Clinical Practice, 12(1), 72-84. https://doi.org/10.1016/j.orcp.2017.08.005

Objectives
Insulin therapy induces weight gain but whether it causes long term adverse metabolic and CV outcomes in obese patients remains unclear.

Methods
A retrospective cohort study of 12,725 insulin initiators with T2D derived from UK Genera... Read More about Effects of obesity on metabolic and cardiovascular outcomes following insulin initiation in patients with type 2 diabetes.

Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: results of a randomised controlled trial (RCT) using two dietary approaches (2017)
Journal Article
Baldry, E., Aithal, G. P., Kaye, P., Idris, I., Bennett, A., Leeder, P. C., & MacDonald, I. A. (2017). Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: results of a randomised controlled trial (RCT) using two dietary approaches. Diabetes, Obesity and Metabolism, 19(8), https://doi.org/10.1111/dom.12918

Short-term very low energy diets (VLED) are used in clinical practice prior to bariatric surgery, however, regimens vary and outcomes for a short intervention are unclear. We examined the effect of two VLEDs; a food-based diet (FD) and meal replaceme... Read More about Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: results of a randomised controlled trial (RCT) using two dietary approaches.

Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review (2016)
Journal Article
Rudrappa, S. S., Wilkinson, D., Greenhaff, P. L., Smith, K., Idris, I., & Atherton, P. J. (2016). Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review. Frontiers in Physiology, 7(361), https://doi.org/10.3389/fphys.2016.00361

The ever increasing burden of an ageing population and pandemic of metabolic syndrome worldwide demands further understanding of the modifiable risk factors in reducing disability and morbidity associated with these conditions. Disuse skeletal muscle... Read More about Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review.