Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men

Sayda, M. H.; Abdul-Aziz, M. H.; Gharahdaghi, N.; Wilkinson, D. J.; Greenhaff, P. L.; Philips, B. E.; Smith, K.; Idris, I.; Atherton, P. J.

doi:10.1038/s41598-022-21814-z

Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies (2025)
Journal Article
Long, T., Milbourn, C. C., Smith, A., Linn Su Khin, K., Page, A. J., Idris, I., Yang, Q., Young, R. L., & Eldeghaidy, S. (2025). Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies. Life, 15(7), Article 1075. https://doi.org/10.3390/life15071075

Sweet sensing is a fundamental sensory experience that plays a critical role not only in food preference, reward and dietary behaviour but also in glucose metabolism. Sweet taste receptors (STRs), composed of a heterodimer of taste receptor type 1 me... Read More about Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies.

The legacy effect of early HbA1c control on microvascular complications and hospital admissions in type 2 diabetes: findings from a large UK study (2025)
Journal Article
Aldafas, R., Vinogradova, Y., Crabtree, T. S. J., Gordon, J., & Idris, I. (2025). The legacy effect of early HbA1c control on microvascular complications and hospital admissions in type 2 diabetes: findings from a large UK study. Therapeutic Advances in Endocrinology and Metabolism, 16, 1-14. https://doi.org/10.1177/20420188251350897

Introduction
There is conflicting evidence regarding optimal glycaemic targets to reflect the legacy effect of hyperglycaemia in people with type 2 diabetes (T2D). We examined the risks of microvascular complications and hospital admission with HbA... Read More about The legacy effect of early HbA1c control on microvascular complications and hospital admissions in type 2 diabetes: findings from a large UK study.

Healthcare Utilisation and Costs in Adults with Type 2 Diabetes Treated with First- or Second-Generation Basal Insulins in England (2025)
Journal Article
Holden, N., Diribe, O., Palmer, K., Puttanna, A., Mahieu, A., Nicholls, C., Li Marston, X., Denholm, N., Saberi Hosnijeh, F., & Idris, I. (2025). Healthcare Utilisation and Costs in Adults with Type 2 Diabetes Treated with First- or Second-Generation Basal Insulins in England. BMJ Open Diabetes Research and Care, 13(3), Article e005027. https://doi.org/10.1136/bmjdrc-2025-005027

Introduction: The prevalence of people with type 2 diabetes (T2D) on basal insulin (BI) is rising to improve glucose control and minimize minimise complications. However, limited evidence exists regarding the economic impact of second-generation BI a... Read More about Healthcare Utilisation and Costs in Adults with Type 2 Diabetes Treated with First- or Second-Generation Basal Insulins in England.

Mechanism of Diabetes Remission or Improvement in Glucose Control Following Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy: A Systematic Review and Meta-Analysis (2025)
Journal Article
Wilmington, R., Ardavani, A., Hasan, N., Alhindi, Y., Ramzan, I., Anyiam, O., & Idris, I. (2025). Mechanism of Diabetes Remission or Improvement in Glucose Control Following Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy: A Systematic Review and Meta-Analysis. Obesities, 5(1), Article 14. https://doi.org/10.3390/obesities5010014

Background: The mechanisms of diabetes remission following bariatric surgery independent of calorie restriction and weight loss remain unclear. Objectives: To undertake a systematic review and meta-analysis to investigate mechanisms underpinning diab... Read More about Mechanism of Diabetes Remission or Improvement in Glucose Control Following Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy: A Systematic Review and Meta-Analysis.

Association between prescribed oral antidiabetic medication for type 2 diabetes mellitus and risk of skin cancer: a systematic review and meta-analysis (2024)
Journal Article
Simpson, C., Leducq, S., Venables, Z., Yiu, Z. Z., Rhodes, L. E., Idris, I., & Gran, S. (2024). Association between prescribed oral antidiabetic medication for type 2 diabetes mellitus and risk of skin cancer: a systematic review and meta-analysis. British Journal of Dermatology, 192(1), 165-167. https://doi.org/10.1093/bjd/ljae341

Metabolic effects of very-low calorie diet, Semaglutide or combination of the two, in individuals with type 2 diabetes mellitus (2024)
Journal Article
Oluwaseun, A., Bethan, P., Katie, Q., Daniel, W., Kenneth, S., Philip, A., & Iskandar, I. (2024). Metabolic effects of very-low calorie diet, Semaglutide or combination of the two, in individuals with type 2 diabetes mellitus. Clinical Nutrition, 43(8), 1907-1913. https://doi.org/10.1016/j.clnu.2024.06.034

Background & aims

Very-low calorie diets (VLCD) and the glucagon-like peptide-1 receptor agonist (GLP1RA) Semaglutide induce significant weight loss and improve glycaemic control in individuals with type 2 diabetes (T2D). This pilot study was cond... Read More about Metabolic effects of very-low calorie diet, Semaglutide or combination of the two, in individuals with type 2 diabetes mellitus.

A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications (2024)
Journal Article
Abuawwad, M., Tibude, A., Bansi, D., Idris, I., & Madhok, B. (2024). A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications. Diabetes, Obesity and Metabolism, 26(7), 2546-2553. https://doi.org/10.1111/dom.15613

Metabolic and bariatric surgeries have been shown to be the most effective strategy to induce and maintain significant weight loss for people living with severe obesity. However, ongoing concerns regarding operative risks, irreversibility and excess... Read More about A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications.

Associations between zinc deficiency, taste changes and salivary flow rate following gastric bypass and sleeve gastrectomy surgeries (2024)
Journal Article
Mozaffar, B., Mozaffar, H., Alkharaiji, M., Elbahrawy, A., & Idris, I. (2024). Associations between zinc deficiency, taste changes and salivary flow rate following gastric bypass and sleeve gastrectomy surgeries. Journal of Nutrition and Metabolism, 2024, Article 1197571. https://doi.org/10.1155/2024/1197571

Background. The prevalence of taste change (hypogeusia) and its association with zinc deficiency is unclear due to differences in methods of assessment. We investigate the prevalence of hypogeusia using mixed methods and link it with changes in zinc... Read More about Associations between zinc deficiency, taste changes and salivary flow rate following gastric bypass and sleeve gastrectomy surgeries.

Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis (2024)
Journal Article
Aldafas, R., Crabtree, T., Alkharaiji, M., Vinogradova, Y., & Idris, I. (2024). Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis. Age and Ageing, 53(1), Article afad254. https://doi.org/10.1093/ageing/afad254

Objective: Sodium-glucose cotransporter-2 inhibitors (SGLT2Is) reduce cardio-metabolic and renal outcomes in patients with type 2 diabetes (T2D) but their efficacy and safety in older or frail individuals remains unclear. Methods: We searched PubMed,... Read More about Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis.

The Effects of Preoperative Glycaemic Control (HbA1c) on Bariatric and Metabolic Surgery Outcomes: Data from a Tertiary-Referral Bariatric Centre in the UK (2024)
Journal Article
Wilmington, R., Abuawwad, M., Holt, G., Anderson, R., Aldafas, R., Awad, S., & Idris, I. (2024). The Effects of Preoperative Glycaemic Control (HbA1c) on Bariatric and Metabolic Surgery Outcomes: Data from a Tertiary-Referral Bariatric Centre in the UK. Obesity Surgery, 34, 850-854. https://doi.org/10.1007/s11695-023-06964-x

Background: Current recommendations advocate the achievement of an optimal glucose control (HbA1c < 69mmol/mol) prior to elective surgery to reduce risks of peri- and post-operative complications, but the relevance for this glycaemic threshold prior... Read More about The Effects of Preoperative Glycaemic Control (HbA1c) on Bariatric and Metabolic Surgery Outcomes: Data from a Tertiary-Referral Bariatric Centre in the UK.

Liraglutide 3.0mg (Saxenda©) for weight loss and remission of pre-diabetes. Real- world clinical evaluation of effectiveness among patients awaiting bariatric surgery (2023)
Journal Article
Wilmington, R., Ardavani, A., Simenacz, A., Green, C., & Idris, I. (2024). Liraglutide 3.0mg (Saxenda©) for weight loss and remission of pre-diabetes. Real- world clinical evaluation of effectiveness among patients awaiting bariatric surgery. Obesity Surgery, 34, 286-289. https://doi.org/10.1007/s11695-023-06895-7

Objective
The effectiveness of liraglutide 3.0 mg (Saxenda) therapy to induce weight loss among obese patients prior to bariatric surgery remains uncertain.

Methods
Clinical data was retrospectively obtained from patients with prediabetes (HbA1c... Read More about Liraglutide 3.0mg (Saxenda©) for weight loss and remission of pre-diabetes. Real- world clinical evaluation of effectiveness among patients awaiting bariatric surgery.

The use of non‐invasive brain stimulation techniques to reduce body weight and food cravings: A systematic review and meta‐analysis (2023)
Journal Article
Alhindi, Y. A., Khalifa, N., Al-Khyatt, W., & Idris, I. (2023). The use of non‐invasive brain stimulation techniques to reduce body weight and food cravings: A systematic review and meta‐analysis. Clinical Obesity, 13(6), Article e12611. https://doi.org/10.1111/cob.12611

Several studies demonstrated non‐invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are safe and simple techniques that can reduce body weight, food cravings... Read More about The use of non‐invasive brain stimulation techniques to reduce body weight and food cravings: A systematic review and meta‐analysis.

Peri- and Postoperative Outcomes for Obstructive Sleep Apnoea Patients after Bariatric Surgery—a Systematic Review and Meta-analysis (2023)
Journal Article
Katasani, T., Holt, G., Al-Khyatt, W., & Idris, I. (2023). Peri- and Postoperative Outcomes for Obstructive Sleep Apnoea Patients after Bariatric Surgery—a Systematic Review and Meta-analysis. Obesity Surgery, 33, 2016-2024. https://doi.org/10.1007/s11695-023-06557-8

Background
Obstructive sleep apnoea (OSA) is prevalent among patients undergoing bariatric surgery. Previous studies have reported a higher risk of complications, ICU admission and longer length of stay in patients with OSA following surgery. Howeve... Read More about Peri- and Postoperative Outcomes for Obstructive Sleep Apnoea Patients after Bariatric Surgery—a Systematic Review and Meta-analysis.

Non-invasive imaging of functional pancreatic islet beta-cell mass in people with type 1 diabetes mellitus (2023)
Journal Article
Joshi, S. S., Singh, T., Kershaw, L. E., Gibb, F. W., Dweck, M. R., Williams, M., Idris, I., Semple, S., Forbes, S., Newby, D. E., & Reynolds, R. M. (2023). Non-invasive imaging of functional pancreatic islet beta-cell mass in people with type 1 diabetes mellitus. Diabetic Medicine, 40(10), Article e15111. https://doi.org/10.1111/dme.15111

To investigate whether manganese-enhanced magnetic resonance imaging can assess functional pancreatic beta-cell mass in people with type 1 diabetes mellitus. In a prospective case-control study, 20 people with type 1 diabetes mellitus (10 with low (≥... Read More about Non-invasive imaging of functional pancreatic islet beta-cell mass in people with type 1 diabetes mellitus.

The Effectiveness of Zinc Supplementation in Taste Disorder Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2023)
Journal Article
Mozaffar, B., Ardavani, A., Muzafar, H., & Idris, I. (2023). The Effectiveness of Zinc Supplementation in Taste Disorder Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Nutrition and Metabolism, 2023, Article 6711071. https://doi.org/10.1155/2023/6711071

Introduction. Food taste and flavour affect food choice and acceptance, which are essential to maintain good health and quality of life. Reduced circulating zinc levels have been shown to adversely affect the taste, but the efficacy of zinc supplemen... Read More about The Effectiveness of Zinc Supplementation in Taste Disorder Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Efficacy and safety of intensive versus conventional glucose targets in people with type 2 diabetes: a systematic review and meta-analysis (2023)
Journal Article
Aldafas, R., Crabtree, T., Vinogradova, Y., Gordon, J. P., & Idris, I. (2023). Efficacy and safety of intensive versus conventional glucose targets in people with type 2 diabetes: a systematic review and meta-analysis. Expert Review of Endocrinology and Metabolism, 18(1), 95-110. https://doi.org/10.1080/17446651.2023.2166489

Objective: The aim of study is to re-evaluate the risk-benefits of intensive glycemic control in the context of multi-factorial intervention in adults with T2D.

Methods: We searched Ovid MEDLINE, Embase, Cochrane, and CINHAL for randomized contro... Read More about Efficacy and safety of intensive versus conventional glucose targets in people with type 2 diabetes: a systematic review and meta-analysis.

Liraglutide 3.0 (Saxenda) in bariatric patients: a retrospective real-world clinical evaluation of effectiveness (2022)
Journal Article
Simenacz, A., Wilmington, R., Green, C., Ardavani, A., & Idris, I. (2022). Liraglutide 3.0 (Saxenda) in bariatric patients: a retrospective real-world clinical evaluation of effectiveness. The British Journal of Diabetes, 22(2), 121-124. https://doi.org/10.15277/bjd.2022.350

Background: Glucagon-like peptide-1 analogues such as liraglutide 3.0 mg (Saxenda) have yielded signiﬁcant weight loss in clinical trials when combined with lifestyle interventions. Despite the recent approval of liraglutide 3.0 mg, its success among... Read More about Liraglutide 3.0 (Saxenda) in bariatric patients: a retrospective real-world clinical evaluation of effectiveness.

Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men (2022)
Journal Article
Abdulla, H., Phillips, B., Wilkinson, D., Gates, A., Limb, M., Jandova, T., Bass, J., Lewis, J., Williams, J., Smith, K., Idris, I., & Atherton, P. (2023). Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men. Journal of Clinical Endocrinology and Metabolism, 108(4), 971-978. https://doi.org/10.1210/clinem/dgac613

Introduction
Ageing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion, independent of insulin action. We thus hypot... Read More about Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men.

A Literature Review of Taste Change and Zinc Deficiency After Bariatric Surgery: Could There Be a Causal Link? (2022)
Journal Article
Mozaffar, B., & Idris, I. (2023). A Literature Review of Taste Change and Zinc Deficiency After Bariatric Surgery: Could There Be a Causal Link?. Obesity Surgery, 33, 313-331. https://doi.org/10.1007/s11695-022-06197-4

In this review, we collated evidence relating to taste change and zinc deficiency in relation to bariatric surgery (BS) and effects of zinc replacement on taste perception and speculate on the possible role of zinc deficiency to induce taste change a... Read More about A Literature Review of Taste Change and Zinc Deficiency After Bariatric Surgery: Could There Be a Causal Link?.

Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men (2022)
Journal Article
Sayda, M. H., Abdul-Aziz, M. H., Gharahdaghi, N., Wilkinson, D. J., Greenhaff, P. L., Philips, B. E., Smith, K., Idris, I., & Atherton, P. J. (2022). Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men. Scientific Reports, 12, Article 19273. https://doi.org/10.1038/s41598-022-21814-z

Higher plasma leucine, isoleucine and valine (BCAA) concentrations are associated with diabetes, obesity and insulin resistance (IR). Here, we evaluated the effects of 6-weeks very-low calorie diet (VLCD) upon fasting BCAA in overweight (OW) non-diab... Read More about Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men.

All Outputs (58)