All Outputs (97)

In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration (2019)
Journal Article
Patel, U., Macri-Pellizzeri, L., Hossain, K. M. Z., Scammell, B. E., Grant, D. M., Scotchford, C. A., …Sottile, V. (2019). In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration. Journal of Tissue Engineering and Regenerative Medicine, 13(3), 396-405. https://doi.org/10.1002/term.2796

Phosphate glasses (PBG) are ideal materials for regenerative medicine strategies since their composition, degradation rates and ion release profiles can easily be controlled. Strontium has previously been found to simultaneously affect bone resorptio... Read More about In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration.

Effects of ZnO addition on thermal properties, degradation and biocompatibility of P45Mg24Ca16Na(15−x)Znx glasses (2019)
Journal Article
Wang, Y., Zhu, C., Parsons, A., Rudd, C., Ahmed, I., & Sharmin, N. (2019). Effects of ZnO addition on thermal properties, degradation and biocompatibility of P45Mg24Ca16Na(15−x)Znx glasses. Biomedical Glasses, 5(1), 53-66. https://doi.org/10.1515/bglass-2019-0005

Four phosphate-based glass formulations in the system P45Mg24Ca16Na(15−x)Znx, referred to as P45Znx (x = 0, 5, 10 and 15 mol%), were prepared using a melt quenching process. The effect of ZnO addition on density, molar volume, thermal properties and... Read More about Effects of ZnO addition on thermal properties, degradation and biocompatibility of P45Mg24Ca16Na(15−x)Znx glasses.

Ga and Ce ion-doped phosphate glass fibres with antibacterial properties and their composite for wound healing applications (2019)
Journal Article
Łapa, A., Cresswell, M., Campbell, I., Jackson, P., Goldmann, W. H., Detsch, R., …Boccaccini, A. R. (2019). Ga and Ce ion-doped phosphate glass fibres with antibacterial properties and their composite for wound healing applications. Journal of Materials Chemistry B, 7(44), 6981-6993. https://doi.org/10.1039/c9tb00820a

© 2019 The Royal Society of Chemistry. Novel gallium/cerium-doped phosphate glass fibres (PGF) were successfully manufactured by the melt-quenching and melt-spinning process. The amorphous character of the materials produced was confirmed using X-ray... Read More about Ga and Ce ion-doped phosphate glass fibres with antibacterial properties and their composite for wound healing applications.

Chitosan as a coupling agent for phosphate glass fibre/polycaprolactone composites (2018)
Journal Article
Tan, C., Rudd, C., Parsons, A. J., Sharmin, N., Zhang, J., Chen, W., & Ahmed, I. (2018). Chitosan as a coupling agent for phosphate glass fibre/polycaprolactone composites. Fibers, 6(4), Article 97. https://doi.org/10.3390/fib6040097

This study shows that chitosan (CS) could be highly useful as a coupling agent in phosphate glass fibre/polycaprolactone (PGF/PCL) composites, as it improved the interfacial shear strength by up to 78%. PGFs of composition 45P2O5-5B2O3-5Na2O-24CaO-10... Read More about Chitosan as a coupling agent for phosphate glass fibre/polycaprolactone composites.

Developing unique geometries of phosphate-based glasses and their prospective biomedical applications (2018)
Journal Article
Ahmed, I., Ren, H., & Booth, J. (2019). Developing unique geometries of phosphate-based glasses and their prospective biomedical applications. Johnson Matthey Technology Review, 63(1), 34-42. https://doi.org/10.1595/205651319x15426460058863

© 2019 Johnson Matthey Phosphate-based glasses are promising materials for a range of applications including biomedical, veterinary and optical. These glasses are distinguished by the presence of at least one terminal oxygen atom, which gives phospha... Read More about Developing unique geometries of phosphate-based glasses and their prospective biomedical applications.

The mechanical property, degradation and cytocompatibility analysis of novel phosphate glass fiber textiles (2018)
Journal Article
Zhu, C., Ahmed, I., Parsons, A., Liu, J., & Liu, X. (2019). The mechanical property, degradation and cytocompatibility analysis of novel phosphate glass fiber textiles. Textile Research Journal, 89(16), 3280-3290. https://doi.org/10.1177/0040517518809052

© The Author(s) 2018. Phosphate glass fibers have been widely considered as potential biomedical materials for orthopedical application due to their full degradability and excellent cytocompatibility. In this study, phosphate-based glass fibers were... Read More about The mechanical property, degradation and cytocompatibility analysis of novel phosphate glass fiber textiles.

Novel bioresorbable textile composites for medical applications (2018)
Presentation / Conference Contribution
Zhu, C., Ahmed, I., Parsons, A. J., Wang, Y., Tan, C., Liu, J., …Liu, X. (2018). Novel bioresorbable textile composites for medical applications. In N/A

Currently, phosphate glass fibre (PGF) reinforced composites are a potential solution for bone repairing due to sufficient mechanical properties and full bioresorbability. In this study, a small inkle-type loom for hand weaving facilitated the produc... Read More about Novel bioresorbable textile composites for medical applications.

Effects of Fe2O3 addition and annealing on the mechanical and dissolution properties of MgO- and CaO-containing phosphate glass fibres for bio-applications (2018)
Journal Article
Tan, C., Ahmed, I., Parsons, A. J., Zhu, C., Betanzos, F. B., & Liu, X. (2018). Effects of Fe2O3 addition and annealing on the mechanical and dissolution properties of MgO- and CaO-containing phosphate glass fibres for bio-applications. Biomedical Glasses, 4(1), https://doi.org/10.1515/bglass-2018-0006

This paper investigated the preparation of phosphate glass fibres (PGFs) in the following systems: i) 45P2O5-5B2O3-5Na2O-(29-x)CaO-16MgO-(x)Fe2O3and ii) 45P2O5-5B2O3-5Na2O-24CaO-(21-x)MgO-(x)Fe2O3(where x = 5, 8 and 11 mol%) for biomedical applicatio... Read More about Effects of Fe2O3 addition and annealing on the mechanical and dissolution properties of MgO- and CaO-containing phosphate glass fibres for bio-applications.

Flexible and transparent films produced from cellulose nanowhisker reinforced agarose (2018)
Journal Article
Felfel, R. M., Hossain, K. M. Z., Kabir, S. F., Yee, S. L., Ahmed, I., & Grant, D. M. (2018). Flexible and transparent films produced from cellulose nanowhisker reinforced agarose. Carbohydrate Polymers, 194, https://doi.org/10.1016/j.carbpol.2018.04.005

Transparent and flexible nanocomposite films with a range of Agarose to Cellulose Nano-Whisker (CNW) ratios were produced using never-dried CNWs. The incorporation of never-dried CNWs within Agarose played an important role in the surface roughness (... Read More about Flexible and transparent films produced from cellulose nanowhisker reinforced agarose.

Porous calcium phosphate glass microspheres for orthobiologic applications (2018)
Journal Article
Hossain, K. M. Z., Patel, U., Kennedy, A. R., Macri-Pellizzeri, L., Sottile, V., Grant, D. M., …Ahmed, I. (2018). Porous calcium phosphate glass microspheres for orthobiologic applications. Acta Biomaterialia, 72, 396-406. https://doi.org/10.1016/j.actbio.2018.03.040

© 2018 Orthobiologics is a rapidly advancing field utilising cell-based therapies and biomaterials to enable the body to repair and regenerate musculoskeletal tissues. This paper reports on a cost-effective flame spheroidisation process for producti... Read More about Porous calcium phosphate glass microspheres for orthobiologic applications.

Electric field-assisted orientation of short phosphate glass fibers on stainless steel for biomedical applications (2018)
Journal Article
Chen, Q., Jing, J., Qi, H., Ahmed, I., Yang, H., Liu, X., …Boccaccini, A. R. (2018). Electric field-assisted orientation of short phosphate glass fibers on stainless steel for biomedical applications. ACS Applied Materials and Interfaces, 10(14), 11529-11538. https://doi.org/10.1021/acsami.8b01378

Structural and compositional modifications of metallic implant surfaces are being actively investigated to achieve improved bone-to-implant bonding. In this study, a strategy to modify bulk metallic surfaces by electrophoretic deposition (EPD) of sho... Read More about Electric field-assisted orientation of short phosphate glass fibers on stainless steel for biomedical applications.

Live quantitative monitoring of mineral deposition in stem cells using tetracycline hydrochloride (2018)
Journal Article
Macri-Pellizzeri, L., De Melo, N., Ahmed, I., Grant, D. M., Scammell, B., & Sottile, V. (2018). Live quantitative monitoring of mineral deposition in stem cells using tetracycline hydrochloride. Tissue Engineering Part C Methods, 24(3), https://doi.org/10.1089/ten.TEC.2017.0400

The final stage of in vitro osteogenic differentiation is characterized by the production of mineral deposits containing calcium cations and inorganic phosphates, which populate the extracellular matrix surrounding the cell monolayer. Conventional hi... Read More about Live quantitative monitoring of mineral deposition in stem cells using tetracycline hydrochloride.

Simulating damage onset and evolution in fully bio-resorbable composite under three-point bending (2018)
Journal Article
Gao, X., Chen, M., Yang, X., Harper, L., Ahmed, I., & Lu, J. (2018). Simulating damage onset and evolution in fully bio-resorbable composite under three-point bending. Journal of the Mechanical Behavior of Biomedical Materials, 81, https://doi.org/10.1016/j.jmbbm.2018.02.022

This paper presents a strain-based damage model to predict the stress-strain relationship and investigate the damage onset and evolution of the fibre and matrix of a fully bio-resorbable phosphate glass fibre reinforced composite under three-point be... Read More about Simulating damage onset and evolution in fully bio-resorbable composite under three-point bending.

Single solvent based film casting method for the production of porous polymer films (2018)
Journal Article
Hossain, K. M. Z., Felfel, R. M., Ogbilikana, P. S., Thakker, D., Grant, D. M., Scotchford, C., & Ahmed, I. (2018). Single solvent based film casting method for the production of porous polymer films. Macromolecular Materials and Engineering, 303, https://doi.org/10.1002/mame.201700628

A single solvent based film casting process for fabricating porous polymer films was developed in this study. The porous film was produced by mixing concentrated polylactic acid/ chloroform solution (20 wt%) and fresh chloroform solvent followed by f... Read More about Single solvent based film casting method for the production of porous polymer films.

Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation (2017)
Journal Article
Gupta, D., Grant, D. M., Hossain, K. M. Z., Ahmed, I., & Sottile, V. (2018). Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation. Journal of Biomaterials Applications, 32(7), https://doi.org/10.1177/0885328217745699

Mesenchymal stem cells play a vital role in bone formation process by differentiating into osteoblasts, in a tissue that offers not a flat but a discontinuous three-dimensional (3D) topography in vivo. In order to understand how geometry may be affec... Read More about Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation.

Novel bioresorbable phosphate glass fiber textile composites for medical applications (2017)
Journal Article
Zhu, C., Ahmed, I., Parsons, A. J., Wang, Y., Tan, C., Liu, J., …Liu, X. (2018). Novel bioresorbable phosphate glass fiber textile composites for medical applications. Polymer Composites, 39(S1), E140-E151. https://doi.org/10.1002/pc.24499

A manual bench-top inkle-type loom was designed to enable hand woven textiles. These PGF textiles, along with unidirectional (UD) fiber mats made from the same batch of yarns, were utilized to manufacture fully resorbable textile composites (T-C), un... Read More about Novel bioresorbable phosphate glass fiber textile composites for medical applications.

Wet and dry flexural high cycle fatigue behaviour of fully bioresorbable glass fibre composites: In-situ polymerisation versus laminate stacking (2017)
Journal Article
Chen, M., Lu, J., Felfel, R. M., Parsons, A. J., Irvine, D. J., Rudd, C. D., & Ahmed, I. (2017). Wet and dry flexural high cycle fatigue behaviour of fully bioresorbable glass fibre composites: In-situ polymerisation versus laminate stacking. Composites Science and Technology, 150, 1-15. https://doi.org/10.1016/j.compscitech.2017.07.006

Fully bioresorbable phosphate based glass fibre reinforced polycaprolactone (PCL/PGF) composites are potentially excellent candidates to address current issues experienced with use of metal implants for hard tissue repair, such as stress shielding ef... Read More about Wet and dry flexural high cycle fatigue behaviour of fully bioresorbable glass fibre composites: In-situ polymerisation versus laminate stacking.

Structural and physico-chemical analysis of calcium/ strontium substituted, near-invert phosphate based glasses for biomedical applications (2017)
Journal Article
Patel, U., Moss, R., Hossain, K., Kennedy, A., Barney, E., Ahmed, I., & Hannon, A. (2017). Structural and physico-chemical analysis of calcium/ strontium substituted, near-invert phosphate based glasses for biomedical applications. Acta Biomaterialia, 60, 109-127. https://doi.org/10.1016/j.actbio.2017.07.002

Neutron diffraction, 23Na and 31P NMR and FTIR spectroscopy have been used to investigate the structural effects of substituting CaO with SrO in a 40P2O5·(16 x)CaO·20Na2O·24MgO·xSrO glass, where x is 0, 4, 8, 12 and 16 mol%. The 31P solid-state NMR r... Read More about Structural and physico-chemical analysis of calcium/ strontium substituted, near-invert phosphate based glasses for biomedical applications.

Mechanical, structural and dissolution properties of heat treated thin-film phosphate based glasses (2017)
Journal Article
Stuart, B. W., Gimeno-Fabra, M., Segal, J., Ahmed, I., & Grant, D. M. (2017). Mechanical, structural and dissolution properties of heat treated thin-film phosphate based glasses. Applied Surface Science, 416, 605-617. https://doi.org/10.1016/j.apsusc.2017.04.110

Here we show the deposition of 2.7 μm thick phosphate based glass films produced by magnetron sputtering, followed by post heat treatments at 500 °C. Variations in degradation properties pre and post heat treatment were attributed to the formation of... Read More about Mechanical, structural and dissolution properties of heat treated thin-film phosphate based glasses.

Structural, thermal and dissolution properties of MgO- and CaO-containing borophosphate glasses: effect of Fe2O3 addition (2017)
Journal Article
Tan, C., Ahmed, I., Parsons, A. J., Sharmin, N., Zhu, C., Liu, J., …Liu, X. (2017). Structural, thermal and dissolution properties of MgO- and CaO-containing borophosphate glasses: effect of Fe2O3 addition. Journal of Materials Science, 52(12), 7489-7502. https://doi.org/10.1007/s10853-017-0981-1

This paper investigated manufacture of high-durability phosphate glass fibres for biomedical applications. Five different borophosphate glass formulations in the systems of 45P2O5–5B2O3–5Na2O–(29 − x)CaO–16MgO–(x)Fe2O3 and 45P2O5–5B2O3–5Na2O–24CaO–(2... Read More about Structural, thermal and dissolution properties of MgO- and CaO-containing borophosphate glasses: effect of Fe2O3 addition.