Electric field-assisted orientation of short phosphate glass fibers on stainless steel for biomedical applications
Chen, Qiang; Jing, Jiajia; Qi, Hongfei; Ahmed, Ifty; Yang, Haiou; Liu, Xianhu; Lu, T. L.; Boccaccini, Aldo R.
Associate Professor IFTY AHMED firstname.lastname@example.org
T. L. Lu
Aldo R. Boccaccini
Structural and compositional modifications of metallic implant surfaces are being actively investigated to achieve improved bone-to-implant bonding. In this study, a strategy to modify bulk metallic surfaces by electrophoretic deposition (EPD) of short phosphate glass fibers (sPGF) is presented. Random and aligned orientation of sPGF embedded in a poly(acrylic acid) matrix is achieved by vertical and horizontal EPD, respectively. The influence of EPD parameters on the degree of alignment is investigated to pave the way for the fabrication of highly aligned sPGF structures in large areas. Importantly, the oriented sPGF structure in the coating, owing to the synergistic effects of bioactive composition and fiber orientation, plays an important role in directional cell migration and enhanced proliferation. Moreover, gene expression of MC3T3-E1 cells cultured with different concentrations of sPGF is thoroughly assessed to elucidate the potential stimulating effect of sPGF on osteogenic differentiation. This study represents an innovative exploitation of EPD to develop textured surfaces by orientation of fibers in the macroscale, which shows great potential for directional functionalization of metallic implants.
|Journal Article Type||Article|
|Publication Date||Apr 11, 2018|
|Journal||ACS Applied Materials & Interfaces|
|Publisher||American Chemical Society|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Chen, Q., Jing, J., Qi, H., Ahmed, I., Yang, H., Liu, X., …Boccaccini, A. R. (2018). Electric field-assisted orientation of short phosphate glass fibers on stainless steel for biomedical applications. ACS Applied Materials and Interfaces, 10(14), 11529-11538. doi:10.1021/acsami.8b01378|
Electric Field-Assisted Orientation of Short Phosphate Glass Fibers
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