All Outputs (7)

Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals (2020)
Journal Article
Luney, M., Lindsay, W., McKeever, T. M., & Moppett, I. K. (2020). Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals. BMJ Open, 10(10), Article e037904. https://doi.org/10.1136/bmjopen-2020-037904

Introduction: An increasing number of people who have a history of acute coronary syndrome or cerebrovascular accident (termed cardiovascular events) are being considered for surgery. Up-to-date evidence of the impact of these prior events is needed... Read More about Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals.

A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF) (2020)
Journal Article
Gillies, M., Ghaffar, S., Moppett, I., Docherty, A., Clarke, S., Rea, N., Stephen, J., Keerie, C., Ray, D., White, T., McLullich, A., Mills, N., Rowley, M., Murthy, K., Pearse, R., Stanworth, S., & Walsh, T. (2021). A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF). British Journal of Anaesthesia, 126(1), 77-86. https://doi.org/10.1016/j.bja.2020.06.048

Background
The optimum transfusion strategy in patients with fractured neck of femur is uncertain, particularly if there is coexisting cardiovascular disease.

Methods
We conducted a prospective, single-centre, randomised feasibility trial of tw... Read More about A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF).

Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis (2020)
Journal Article
Noah, A. M., Almghairbi, D., & Moppett, I. K. (2020). Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis. Clinical Neurology and Neurosurgery, 196, Article 106036. https://doi.org/10.1016/j.clineuro.2020.106036

Thinning of retinal layers, measured using optical coherence tomography (OCT), is associated with some neurodegenerative disorders such as established Alzheimer’s disease and multiple sclerosis. The evidence for retinal layer thinning in both mild co... Read More about Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis.

Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching (2020)
Journal Article
Morgan, L., McKeever, T. M., Nightingale, J., Deakin, D. E., & Moppett, I. K. (2020). Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching. Anaesthesia, 75(9), 1173-1179. https://doi.org/10.1111/anae.15042

Around 76,000 people fracture their hip annually in the UK at a considerable personal, social and financial cost. Despite longstanding debate, the optimal mode of anaesthesia (general or spinal) remains unclear. Our aim was to assess whether there is... Read More about Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching.

Guidance in an uncertain world (2020)
Journal Article
Moppett, I. K., Gardiner, D., & Harvey, D. J. R. (2020). Guidance in an uncertain world. British Journal of Anaesthesia, 125(1), 7-9. https://doi.org/10.1016/j.bja.2020.04.003

In the face of the coronavirus pandemic, clinicians are looking to multiple sources for guidance. Good guidance provides a helpful tool to support decision making by experienced and highly-trained healthcare professionals. However, in the context of... Read More about Guidance in an uncertain world.

Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial (2020)
Journal Article
Macho, O., Borges, F. K., Bhandari, M., Guerra-Farfan, E., Patel, A., Sigamani, A., Umer, M., Tiboni, M. E., Villar-Casares, M. D. M., Tandon, V., Tomas-Hernandez, J., Teixidor-Serra, J., Avram, V. R., Winemaker, M., Ramokgopa, M. T., Szczeklik, W., Landoni, G., Wang, C. Y., Begum, D., Neary, J. D., …Quintas, S. (2020). Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial. Lancet, 395(10225), 698-708. https://doi.org/10.1016/s0140-6736%2820%2930058-1

Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine (2020)
Journal Article
Lindsay, W. A., Murphy, M. M., Almghairbi, D. S., & Moppett, I. K. (2020). Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine. Anaesthesia, 75(6), 809-815. https://doi.org/10.1111/anae.14967

The applicability of the results of any clinical trial will depend to a large extent on whether the study population is representative of the population seen in clinical practice. The growing older surgical population presents challenges for peri-ope... Read More about Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine.