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All Outputs (32)

Risk of mortality following surgery in patients with a previous cerebrovascular accident or acute coronary syndrome: a 10-year database linkage between Hospital Episode Statistics, Myocardial Infarction National Audit Project, and Office for National Statistics (2023)
Journal Article
Chalitsios, C. V., Luney, M. S., Lindsay, W., Sanders, R. D., McKeever, T. M., & Moppett, I. (2024). Risk of mortality following surgery in patients with a previous cerebrovascular accident or acute coronary syndrome: a 10-year database linkage between Hospital Episode Statistics, Myocardial Infarction National Audit Project, and Office for National Statistics. JAMA Surgery, 159(2), 140-149. https://doi.org/10.1001/jamasurg.2023.5951

Importance: There is a lack of consensus regarding the interval of time-dependent postoperative mortality risk following an acute coronary syndrome or stroke.
Objective: To determine the magnitude and duration of risk associated with the time interv... Read More about Risk of mortality following surgery in patients with a previous cerebrovascular accident or acute coronary syndrome: a 10-year database linkage between Hospital Episode Statistics, Myocardial Infarction National Audit Project, and Office for National Statistics.

Patient characteristics, anaesthetic workload and techniques in the UK: an analysis from the 7th National Audit Project (NAP7) activity survey (2023)
Journal Article
Kane, A. D., Soar, J., Armstrong, R. A., Kursumovic, E., Davies, M. T., Oglesby, F. C., Cortes, L., Taylor, C., Moppett, I. K., Agarwal, S., Cordingley, J., Dorey, J., Finney, S. J., Kunst, G., Lucas, D. N., Nickols, G., Mouton, R., Nolan, J. P., Patel, B., Pappachan, V. J., …Kailainathan, P. (2023). Patient characteristics, anaesthetic workload and techniques in the UK: an analysis from the 7th National Audit Project (NAP7) activity survey. Anaesthesia, 78(6), 701-711. https://doi.org/10.1111/anae.15989

Detailed contemporary knowledge of the characteristics of the surgical population, national anaesthetic workload, anaesthetic techniques and behaviours are essential to monitor productivity, inform policy and direct research themes. Every 3–4 years,... Read More about Patient characteristics, anaesthetic workload and techniques in the UK: an analysis from the 7th National Audit Project (NAP7) activity survey.

Early mortality outcomes of patients with fragility hip fracture and concurrent SARS-CoV-2 infection: a systematic review and meta-analysis (2021)
Journal Article
Alcock, H., Moppett, E., & Moppett, I. (2021). Early mortality outcomes of patients with fragility hip fracture and concurrent SARS-CoV-2 infection: a systematic review and meta-analysis. Bone & Joint Open, 2(5), 314-322. https://doi.org/10.1302/2633-1462.25.BJO-2020-0183.R1

Aims
Hip fracture is a common condition of the older, frailer person. This population is also at risk from SARS-CoV-2 infection. It is important to understand the impact of coexistent hip fracture and SARS-CoV-2 for informed decision-making at patie... Read More about Early mortality outcomes of patients with fragility hip fracture and concurrent SARS-CoV-2 infection: a systematic review and meta-analysis.

Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals (2020)
Journal Article
Luney, M., Lindsay, W., McKeever, T. M., & Moppett, I. K. (2020). Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals. BMJ Open, 10(10), Article e037904. https://doi.org/10.1136/bmjopen-2020-037904

Introduction: An increasing number of people who have a history of acute coronary syndrome or cerebrovascular accident (termed cardiovascular events) are being considered for surgery. Up-to-date evidence of the impact of these prior events is needed... Read More about Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals.

A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF) (2020)
Journal Article
Gillies, M., Ghaffar, S., Moppett, I., Docherty, A., Clarke, S., Rea, N., Stephen, J., Keerie, C., Ray, D., White, T., McLullich, A., Mills, N., Rowley, M., Murthy, K., Pearse, R., Stanworth, S., & Walsh, T. (2021). A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF). British Journal of Anaesthesia, 126(1), 77-86. https://doi.org/10.1016/j.bja.2020.06.048

Background
The optimum transfusion strategy in patients with fractured neck of femur is uncertain, particularly if there is coexisting cardiovascular disease.

Methods
We conducted a prospective, single-centre, randomised feasibility trial of tw... Read More about A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF).

Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis (2020)
Journal Article
Noah, A. M., Almghairbi, D., & Moppett, I. K. (2020). Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis. Clinical Neurology and Neurosurgery, 196, Article 106036. https://doi.org/10.1016/j.clineuro.2020.106036

Thinning of retinal layers, measured using optical coherence tomography (OCT), is associated with some neurodegenerative disorders such as established Alzheimer’s disease and multiple sclerosis. The evidence for retinal layer thinning in both mild co... Read More about Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis.

Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching (2020)
Journal Article
Morgan, L., McKeever, T. M., Nightingale, J., Deakin, D. E., & Moppett, I. K. (2020). Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching. Anaesthesia, 75(9), 1173-1179. https://doi.org/10.1111/anae.15042

Around 76,000 people fracture their hip annually in the UK at a considerable personal, social and financial cost. Despite longstanding debate, the optimal mode of anaesthesia (general or spinal) remains unclear. Our aim was to assess whether there is... Read More about Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching.

Guidance in an uncertain world (2020)
Journal Article
Moppett, I. K., Gardiner, D., & Harvey, D. J. R. (2020). Guidance in an uncertain world. British Journal of Anaesthesia, 125(1), 7-9. https://doi.org/10.1016/j.bja.2020.04.003

In the face of the coronavirus pandemic, clinicians are looking to multiple sources for guidance. Good guidance provides a helpful tool to support decision making by experienced and highly-trained healthcare professionals. However, in the context of... Read More about Guidance in an uncertain world.

Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial (2020)
Journal Article
Macho, O., Borges, F. K., Bhandari, M., Guerra-Farfan, E., Patel, A., Sigamani, A., Umer, M., Tiboni, M. E., Villar-Casares, M. D. M., Tandon, V., Tomas-Hernandez, J., Teixidor-Serra, J., Avram, V. R., Winemaker, M., Ramokgopa, M. T., Szczeklik, W., Landoni, G., Wang, C. Y., Begum, D., Neary, J. D., …Quintas, S. (2020). Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial. Lancet, 395(10225), 698-708. https://doi.org/10.1016/s0140-6736%2820%2930058-1

Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine (2020)
Journal Article
Lindsay, W. A., Murphy, M. M., Almghairbi, D. S., & Moppett, I. K. (2020). Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine. Anaesthesia, 75(6), 809-815. https://doi.org/10.1111/anae.14967

The applicability of the results of any clinical trial will depend to a large extent on whether the study population is representative of the population seen in clinical practice. The growing older surgical population presents challenges for peri-ope... Read More about Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine.

The effect of intravenous iron on erythropoiesis in older people with hip fracture (2019)
Journal Article
Moppett, I., Rowlands, M., Mannings, A., Marufu, T., Sahota, O., & Yeung, J. (2019). The effect of intravenous iron on erythropoiesis in older people with hip fracture. Age and Ageing, 48(5), 751–755. https://doi.org/10.1093/ageing/afz049

Background: Anaemia following hip fracture is common and associated with worse outcomes. Intravenous iron is a potential non-transfusion treatment for this anaemia and has been found to reduce transfusion rates in previous observational studies. Ther... Read More about The effect of intravenous iron on erythropoiesis in older people with hip fracture.

Short-term morbidity factors associated with length of hospital stay (LOS): development and validation of a hip fracture specific postoperative morbidity survey (HF-POMS) (2019)
Journal Article
Moppett, I. (2019). Short-term morbidity factors associated with length of hospital stay (LOS): development and validation of a hip fracture specific postoperative morbidity survey (HF-POMS). Injury, 50(4), 931-938. https://doi.org/10.1016/j.injury.2019.03.009

Background: We aimed to describe and quantify postoperative complications in the older hip fracture population, develop and validate a hip fracture postoperative morbidity survey tool (HF–POMS).

Methods: A prospective clinical observation study o... Read More about Short-term morbidity factors associated with length of hospital stay (LOS): development and validation of a hip fracture specific postoperative morbidity survey (HF-POMS).

Hip fracture outcomes in patients with COPD (2018)
Journal Article
Buss, L., McKeever, T. M., Nightingale, J., Akyea, R., Ollivere, B., Moppett, I., & Bolton, C. E. (2018). Hip fracture outcomes in patients with COPD. British Journal of Anaesthesia, 121(6), 1377-1379. https://doi.org/10.1016/j.bja.2018.09.008+hideArticle+Info

Hip fractures are common in patients with COPD and contemporary outcome data is needed. Patients admitted with a hip fracture to one acute trust (2010-2015) were assessed prospectively (UK National Hip Fracture Database audit) and mortality data col... Read More about Hip fracture outcomes in patients with COPD.

Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial (2018)
Journal Article
Rowlands, M., Walt, G. V. D., Bradley, J., Mannings, A., Armstrong, S., Bedforth, N. M., Moppett, I. K., & Sahota, O. (2018). Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial. BMJ Open, 8(4), Article e019650. https://doi.org/10.1136/bmjopen-2017-019650

Objective

Fractured neck of femur is a severely painful condition with significant mortality and morbidity. We investigated whether early and continuous use of femoral nerve block can improve pain on movement and mobility after surgery in older p... Read More about Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial.

Anaesthesia workload measurement devices: qualitative systematic review (2018)
Journal Article
Almghairbi, D. S., Marufu, T. C., & Moppett, I. K. (2018). Anaesthesia workload measurement devices: qualitative systematic review. BMJ Simulation & Technology Enhanced Learning, 4(3), 112-116. https://doi.org/10.1136/bmjstel-2017-000263

Background: Management of mental workload is a key aspect of safety in anaesthesia but there is no gold standard tool to assess mental workload, risking confusion in clinical and research use of such tools.

Objective: This review assessed currentl... Read More about Anaesthesia workload measurement devices: qualitative systematic review.

International Fragility Fracture Network Delphi consensus statement on the principles of anaesthesia for patients with hip fracture (2018)
Journal Article
White, S., Altermatt, F., Barry, J., Ben-David, B., Coburn, M., Coluzzi, F., Degoli, M., Dillane, D., Foss, N., Gelmanas, A., Griffiths, R., Karpetas, G., Kim, J.-H., Kluger, M., Lau, P.-W., Matot, I., McBrien, M., McManus, S., Montoya-Pelaez, L., Moppett, I., …Xuebing, X. (2018). International Fragility Fracture Network Delphi consensus statement on the principles of anaesthesia for patients with hip fracture. Anaesthesia, 73(7), 863-874. https://doi.org/10.1111/anae.14225

Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics (2018)
Journal Article
Sanderson, M., Chikhani, M., Blyth, E., Wood, S., Moppett, I. K., McKeever, T., & Simmonds, M. J. (2018). Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics. Journal of the Intensive Care Society, 19(4), 299-304. https://doi.org/10.1177/1751143718758975

Background

Sepsis represents a significant public health burden, costing the NHS £2.5 billion annually, with 35% mortality in 2006. The aim of this exploratory study was to investigate risk factors predictive of 30-day mortality amongst patients w... Read More about Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics.

An observational feasibility study of a new anaesthesia drug storage tray (2018)
Journal Article
Almghairbi, D. S., Sharp, L., Griffiths, R., Evley, R., Gupta, S., & Moppett, I. K. (2018). An observational feasibility study of a new anaesthesia drug storage tray. Anaesthesia, 73(3), 356-364. https://doi.org/10.1111/anae.14187

Drug errors in the anaesthetic domain remains a serious cause of iatrogenic harm. To help reduce this issue, we aimed to explore the potential impact of a simple colour-coded tray to drug preparation and storage on safe drug administration during ana... Read More about An observational feasibility study of a new anaesthesia drug storage tray.

Tight intra-operative blood pressure control versus standard care for patients undergoing hip fracture repair - Hip Fracture Intervention Study for Prevention of Hypotension (HIP-HOP) trial: study protocol for a randomised controlled trial (2017)
Journal Article
Moppett, I. K., White, S., Griffiths, R., & Buggy, D. (in press). Tight intra-operative blood pressure control versus standard care for patients undergoing hip fracture repair - Hip Fracture Intervention Study for Prevention of Hypotension (HIP-HOP) trial: study protocol for a randomised controlled trial. Trials, 18(1), https://doi.org/10.1186/s13063-017-2066-5

Background: Hypotension during anaesthesia for hip fracture surgery is common. Recent data suggest that there is an association between the lowest intra-operative blood pressure and mortality, even when adjusted for co-morbidities. This is consistent... Read More about Tight intra-operative blood pressure control versus standard care for patients undergoing hip fracture repair - Hip Fracture Intervention Study for Prevention of Hypotension (HIP-HOP) trial: study protocol for a randomised controlled trial.