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Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 2: education, training and capacity building (2022)
Journal Article
Layfield, C. P., Williams, H. C., & The UK Dermatology Clinical Trials Network. (2022). Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 2: education, training and capacity building. Clinical and Experimental Dermatology, 47(6), 1060-1067. https://doi.org/10.1111/ced.15132

In Part 1 of this 2-part review of the 20th anniversary of the UK Dermatology Clinical Trials Network (UK DCTN), we described its role in developing and supporting clinical trial proposals, elaborating on structure, process and clinical trials activi... Read More about Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 2: education, training and capacity building.

Avoidable research waste in dermatology: what are the solutions? (2022)
Journal Article
Williams, H. C. (2022). Avoidable research waste in dermatology: what are the solutions?. British Journal of Dermatology, 186(4), 599-601. https://doi.org/10.1111/bjd.20755

In the last editorial, I provided examples of research waste in dermatology and suggested that it was due to a system failure rather than just a few “bad apples”. Here, I focus on possible solutions, mainly in relation to clinical trials, building on... Read More about Avoidable research waste in dermatology: what are the solutions?.

Avoidable research waste in dermatology: what are the solutions? (2022)
Journal Article
Williams, H. C. (2022). Avoidable research waste in dermatology: what are the solutions?. British Journal of Dermatology, 186(4), 599-601. https://doi.org/10.1111/bjd.20755

In the last editorial, I provided examples of research waste in dermatology and suggested that it was due to a system failure rather than just a few “bad apples”. Here, I focus on possible solutions, mainly in relation to clinical trials, building on... Read More about Avoidable research waste in dermatology: what are the solutions?.

The HOME Core outcome set for clinical trials of atopic dermatitis (2022)
Journal Article
Williams, H. C., Schmitt, J., Thomas, K. S., Spuls, P. I., Simpson, E. L., Apfelbacher, C. J., …Boers, M. (2022). The HOME Core outcome set for clinical trials of atopic dermatitis. Journal of Allergy and Clinical Immunology, 149(6), 1899-1911. https://doi.org/10.1016/j.jaci.2022.03.017

Core outcome sets are critically important outcomes that should be measured in clinical trials. Their absence in atopic dermatitis is a form of research waste and impedes combining evidence to inform patient care. Here, we articulate the rationale fo... Read More about The HOME Core outcome set for clinical trials of atopic dermatitis.

Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics (2022)
Journal Article
Bosma, A. L., Ascott, A., Iskandar, R., Farquhar, K., Matthewman, J., Langendam, M. W., …Middelkamp-Hup, M. A. (2022). Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics. Journal of the European Academy of Dermatology and Venereology, 36(6), 807-819. https://doi.org/10.1111/jdv.18008

Atopic dermatitis is a heterogeneous disease, accompanied by a wide variation in disease presentation and the potential to identify many phenotypes that may be relevant for prognosis and treatment. We aimed to systematically review previously reporte... Read More about Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.

Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials (2022)
Journal Article
Williams, H. C., McPhee, M., Layfield, C., & The UK Dermatology Clinical Trials Network. (2022). Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials. Clinical and Experimental Dermatology, 47(6), 1048-1059. https://doi.org/10.1111/ced.15140

The UK Dermatology Clinical Trials Network (UK DCTN) was formed in 2002 with the aim of developing and supporting high-quality independent national clinical trials that address prioritized research questions for people with skin disease. Its philosop... Read More about Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials.

Response to ‘The role of curettage as an intervention for basal cell carcinoma’. Re. ‘Interventions for basal cell carcinoma: abridged Cochrane systematic review and GRADE assessments’: reply from the authors (2021)
Journal Article
Bath-Hextall, F. J., Thomson, J., Hogan, S., Leonardi-Bee, J., Williams, H. C., & Bath‐Hextall, F. (2022). Response to ‘The role of curettage as an intervention for basal cell carcinoma’. Re. ‘Interventions for basal cell carcinoma: abridged Cochrane systematic review and GRADE assessments’: reply from the authors. British Journal of Dermatology, 186(4), 751-752. https://doi.org/10.1111/bjd.20950

Patterns of Atopic Eczema Disease Activity from Birth through Midlife in 2 British Birth Cohorts (2021)
Journal Article
Abuabara, K., Ye, M., Margolis, D. J., Mcculloch, C. E., Mulick, A. R., Silverwood, R. J., …Langan, S. M. (2021). Patterns of Atopic Eczema Disease Activity from Birth through Midlife in 2 British Birth Cohorts. JAMA Dermatology, 157(10), 1191-1199. https://doi.org/10.1001/jamadermatol.2021.2489

Importance: Atopic eczema is characterized by a heterogenous waxing and waning course, with variable age of onset and persistence of symptoms. Distinct patterns of disease activity such as early-onset/resolving and persistent disease have been identi... Read More about Patterns of Atopic Eczema Disease Activity from Birth through Midlife in 2 British Birth Cohorts.

Realising the full potential of data-enabled trials in the UK: a call for action (2021)
Journal Article
Sydes, M. R., Barbachano, Y., Bowman, L., Denwood, T., Farmer, A., Garfield-Birkbeck, S., …Valentine, J. (2021). Realising the full potential of data-enabled trials in the UK: a call for action. BMJ Open, 11(6), 1-15. https://doi.org/10.1136/bmjopen-2020-043906

Rationale: Clinical trials are the gold standard for testing interventions. COVID-19 has further raised their public profile, and emphasised the need to deliver better, faster, more efficient trials for patient benefit. Considerable overlap exists be... Read More about Realising the full potential of data-enabled trials in the UK: a call for action.

Faculty Opinions Recommendation of [Scher JU and Schett G, Nat Rev Rheumatol 2021 17(2):119-124] (2021)
Other
Williams, H. (2021). Faculty Opinions Recommendation of [Scher JU and Schett G, Nat Rev Rheumatol 2021 17(2):119-124]

This is the best article I have ever read on the phenomenon of key opinion leaders (KOLs) – senior influencers who are paid by the pharmaceutical industry to influence prescribing by clinicians at meetings and through writing. The depth of analysis a... Read More about Faculty Opinions Recommendation of [Scher JU and Schett G, Nat Rev Rheumatol 2021 17(2):119-124].

Evidence-based management of eczema: five things that should be done more and five things that should be dropped (2021)
Journal Article
Olabi, B., & Williams, H. C. (2021). Evidence-based management of eczema: five things that should be done more and five things that should be dropped. Current Opinion in Allergy and Clinical Immunology, 21(4), 386-393. https://doi.org/10.1097/ACI.0000000000000750

Purpose of review

We provide readers with an evidence-informed opinion on current treatments for eczema (atopic dermatitis) with the intention of improving patient care. We suggest five treatment aspects that should be promoted and five that shou... Read More about Evidence-based management of eczema: five things that should be done more and five things that should be dropped.

Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve (2021)
Journal Article
Treweek, S., Banister, K., Bower, P., Cotton, S., Devane, D., Gardner, H. R., …Witham, M. D. (2021). Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve. Trials, 22(1), Article 337. https://doi.org/10.1186/s13063-021-05276-8

Background

Ensuring that a trial is designed so that its participants reflect those who might benefit from the results, or be spared harms, is key to the potential benefits of the trial reaching all they should. This paper describes the process, f... Read More about Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve.

Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma (2021)
Journal Article
Boitor, R., de Wolf, C., Weesie, F., Shipp, D. W., Varma, S., Veitch, D., …Notingher, I. (2021). Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma. Biomedical Optics Express, 12(4), 2015-2026. https://doi.org/10.1364/boe.417896

We present the first clinical integration of a prototype device based on integrated auto-fluorescence imaging and Raman spectroscopy (Fast Raman device) for intra-operative assessment of surgical margins during Mohs micrographic surgery of basal cell... Read More about Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma.

Association of frequent moisturizer use in early infancy with the development of food allergy (2021)
Journal Article
Perkin, M. R., Logan, K., Marrs, T., Radulovic, S., Craven, J., Boyle, R. J., …Flohr, C. (2021). Association of frequent moisturizer use in early infancy with the development of food allergy. Journal of Allergy and Clinical Immunology, 147(3), 967-976.e1. https://doi.org/10.1016/j.jaci.2020.10.044

Background
Food allergy is thought to develop through transcutaneous sensitization, especially in the presence of skin barrier impairment and inflammation. Regular moisturizer application to infant skin could potentially promote transcutaneous sensi... Read More about Association of frequent moisturizer use in early infancy with the development of food allergy.

Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers (2021)
Journal Article
Muller, I., Stuart, B., Sach, T., Hooper, J., Wilczynska, S., Steele, M., …Santer, M. (2021). Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers. BMJ Open, 11(2), Article e045583. https://doi.org/10.1136/bmjopen-2020-045583

Introduction Eczema care requires management of triggers and various treatments. We developed two online behavioural interventions to support eczema care called ECO (Eczema Care Online) for young people and ECO for families. This protocol describes t... Read More about Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers.