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Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment (2023)
Journal Article
Fayyaz, H. A., EL-Massik, M. A., Bahey-El-Din, M., Abdel-Bary, A., Abdallah, O. Y., & Eltaher, H. M. (2024). Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment. International Journal of Pharmaceutics, 649, Article 123663. https://doi.org/10.1016/j.ijpharm.2023.123663

Invasive pulmonary aspergillosis (IPA) is the most devastating Aspergillus-related lung disease. Voriconazole (VRZ) is the first-line treatment against IPA. Despite availability in oral and parenteral dosage forms, risks of systemic toxicity dictate... Read More about Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment.

Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing (2023)
Journal Article
Metwally, W. M., El-Habashy, S. E., El-Hosseiny, L. S., Essawy, M. M., Eltaher, H. M., El-Khordagui, L., & El-Khordagui, L. K. (2023). Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing. Biofabrication, 16(1), Article 015001. https://doi.org/10.1088/1758-5090/acfd60

There is a constant demand for novel materials/biomedical devices to accelerate the healing of hard-to-heal wounds. Herein, an innovative 3D-printed bioinspired construct was developed as an antibacterial/regenerative scaffold for diabetic wound heal... Read More about Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing.

Orally-delivered insulin-peptide nanocomplexes enhance transcytosis from cellular depots and improve diabetic blood glucose control (2023)
Journal Article
Rehmani, S., McLaughlin, C. M., Eltaher, H. M., Moffett, R. C., Flatt, P. R., & Dixon, J. E. (2023). Orally-delivered insulin-peptide nanocomplexes enhance transcytosis from cellular depots and improve diabetic blood glucose control. Journal of Controlled Release, 360, 93-109. https://doi.org/10.1016/j.jconrel.2023.06.006

Insulin regulates blood glucose levels, and is the mainstay for the treatment of type-1 diabetes and type-2 when other drugs provide inadequate control. Therefore, effective oral Insulin delivery would be a significant advance in drug delivery. Herei... Read More about Orally-delivered insulin-peptide nanocomplexes enhance transcytosis from cellular depots and improve diabetic blood glucose control.

Nano zinc oxide-functionalized nanofibrous microspheres: A bioactive hybrid platform with antimicrobial, regenerative and hemostatic activities (2023)
Journal Article
Metwally, W. M., El-Habashy, S. E., El-Nikhely, N. A., Mahmoud, H. E., Eltaher, H. M., & El-Khordagui, L. (2023). Nano zinc oxide-functionalized nanofibrous microspheres: A bioactive hybrid platform with antimicrobial, regenerative and hemostatic activities. International Journal of Pharmaceutics, 638, Article 122920. https://doi.org/10.1016/j.ijpharm.2023.122920

Bioactive hybrid constructs are at the cutting edge of innovative biomaterials. PLA nanofibrous microspheres (NF-MS) were functionalized with zinc oxide nanoparticles (nZnO) and DDAB-modified nZnO (D-nZnO) for developing inorganic/nano-microparticula... Read More about Nano zinc oxide-functionalized nanofibrous microspheres: A bioactive hybrid platform with antimicrobial, regenerative and hemostatic activities.

Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings (2022)
Journal Article
Eltaher, H. M., Blokpoel Ferreras, L. A., Jalal, A. R., & Dixon, J. (2022). Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings. Biomaterials Advances, 143, Article 213177. https://doi.org/10.1016/j.bioadv.2022.213177

Nanotechnologies are being increasingly applied as systems for peptide and nucleic acid macromolecule drug delivery. However systemic targeting of these, or efficient topical and localized delivery remains an issue. A controlled release system that c... Read More about Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings.

Prodigiosin-Functionalized Probiotic Ghosts as a Bioinspired Combination Against Colorectal Cancer Cells (2022)
Journal Article
Saleh, N., Mahmoud, H. E., Eltaher, H., Helmy, M., El-Khordagui, L., & Hussein, A. A. (2023). Prodigiosin-Functionalized Probiotic Ghosts as a Bioinspired Combination Against Colorectal Cancer Cells. Probiotics and Antimicrobial Proteins, 15(5), 1271-1286. https://doi.org/10.1007/s12602-022-09980-y

Lactobacillus acidophilus ghosts (LAGs) with the unique safety of a probiotic, inherent tropism for colon cells, and multiple bioactivities offer promise as drug carriers for colon targeting. Our objective was to evaluate LAGs functionalized with pro... Read More about Prodigiosin-Functionalized Probiotic Ghosts as a Bioinspired Combination Against Colorectal Cancer Cells.

Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal (2021)
Journal Article
El-Melegy, M. G., Eltaher, H. M., Gaballah, A., & El-Kamel, A. H. (2021). Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal. European Journal of Pharmaceutics and Biopharmaceutics, 168, 166-183. https://doi.org/10.1016/j.ejpb.2021.08.020

Hepatocellular carcinoma (HCC) is a prevalent liver cancer representing the fourth most lethal cancer worldwide. Trans-Resveratrol (T-R) possesses a promising anticancer activity against HCC. However, it suffers from poor bioavailability because of t... Read More about Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal.

3D printed bioinspired scaffolds integrating doxycycline nanoparticles: Customizable implants for in vivo osteoregeneration (2021)
Journal Article
El-Habashy, S. E., El-Kamel, A. H., Essawy, M. M., Abdelfattah, E. Z. A., & Eltaher, H. M. (2021). 3D printed bioinspired scaffolds integrating doxycycline nanoparticles: Customizable implants for in vivo osteoregeneration. International Journal of Pharmaceutics, 607, Article 121002. https://doi.org/10.1016/j.ijpharm.2021.121002

3D printing has revolutionized pharmaceutical research, with applications encompassing tissue regeneration and drug delivery. Adopting 3D printing for pharmaceutical drug delivery personalization via nanoparticle-reinforced hydrogel scaffolds promise... Read More about 3D printed bioinspired scaffolds integrating doxycycline nanoparticles: Customizable implants for in vivo osteoregeneration.

3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair (2021)
Journal Article
Hamid, O. A., Eltaher, H. M., Sottile, V., & Yang, J. (2021). 3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair. Materials Science and Engineering: C, 120, Article 111707. https://doi.org/10.1016/j.msec.2020.111707

© 2020 Elsevier B.V. Development of a biomimetic tubular scaffold capable of recreating developmental neurogenesis using pluripotent stem cells offers a novel strategy for the repair of spinal cord tissues. Recent advances in 3D printing technology h... Read More about 3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair.

Hybrid bioactive hydroxyapatite/polycaprolactone nanoparticles for enhanced osteogenesis (2020)
Journal Article
El-Habashy, S. E., Eltaher, H. M., Gaballah, A., Zaki, E. I., Mehanna, R. A., & El-Kamel, A. H. (2021). Hybrid bioactive hydroxyapatite/polycaprolactone nanoparticles for enhanced osteogenesis. Materials Science and Engineering: C, 119, Article 111599. https://doi.org/10.1016/j.msec.2020.111599

Hydroxyapatite nanoparticles (HApN) are largely employed as osteogenic inorganic material. Inorganic/polymeric hybrid nanostructures can provide versatile bioactivity for superior osteogenicity, particularly as nanoparticles. Herein, we present hybri... Read More about Hybrid bioactive hydroxyapatite/polycaprolactone nanoparticles for enhanced osteogenesis.

Human-scale tissues with patterned vascular networks by additive manufacturing of sacrificial sugar-protein composites (2020)
Journal Article
Eltaher, H. M., Abukunna, F. E., Ruiz-Cantu, L., Stone, Z., Yang, J., & Dixon, J. E. (2020). Human-scale tissues with patterned vascular networks by additive manufacturing of sacrificial sugar-protein composites. Acta Biomaterialia, 113, 339-349. https://doi.org/10.1016/j.actbio.2020.06.012

© 2020 Combating necrosis, by supplying nutrients and removing waste, presents the major challenge for engineering large three-dimensional (3D) tissues. Previous elegant work used 3D printing with carbohydrate glass as a cytocompatible sacrificial te... Read More about Human-scale tissues with patterned vascular networks by additive manufacturing of sacrificial sugar-protein composites.

Vancomycin-functionalized Eudragit-based nanofibers: Tunable drug release and wound healing efficacy (2020)
Journal Article
Abdel-Rahman, L. M., Eltaher, H. M., Abdelraouf, K., Bahey-El-Din, M., Ismail, C., Kenawy, E. R. S., & El-Khordagui, L. K. (2020). Vancomycin-functionalized Eudragit-based nanofibers: Tunable drug release and wound healing efficacy. Journal of Drug Delivery Science and Technology, 58, Article 101812. https://doi.org/10.1016/j.jddst.2020.101812

There is an unmet demand for local vancomycin (VAN) delivery scaffolds with site retention and tunable release properties for cutaneous and surgical wounds. Nanofibers as drug delivery/cell regeneration promoting scaffolds offer great promise in this... Read More about Vancomycin-functionalized Eudragit-based nanofibers: Tunable drug release and wound healing efficacy.