All Outputs (50)

Potentiation rather than distraction in a trace fear conditioning procedure (2016)
Journal Article
Pezze, M. A., Marshall, H. J., & Cassaday, H. J. (2016). Potentiation rather than distraction in a trace fear conditioning procedure. Behavioural Processes, 128, 41-61. https://doi.org/10.1016/j.beproc.2016.04.003

Trace conditioning procedures are defined by the introduction of a trace interval between conditioned stimulus (CS, e.g. noise or light) offset and unconditioned stimulus (US, e.g. footshock). The introduction of an additional stimulus as a distracto... Read More about Potentiation rather than distraction in a trace fear conditioning procedure.

Conditioned inhibition of emotional responses: retardation and summation with cues for IAPS outcomes (2015)
Journal Article
Thurston, M. D., & Cassaday, H. J. (2015). Conditioned inhibition of emotional responses: retardation and summation with cues for IAPS outcomes. Learning and Motivation, 52, https://doi.org/10.1016/j.lmot.2015.10.002

Conditioned inhibition occurs when a stimulus inhibits the responses that would normally occur to a conditioned stimulus that previously predicted an outcome of interest (the unconditioned stimulus, which elicits responding unconditionally). The pres... Read More about Conditioned inhibition of emotional responses: retardation and summation with cues for IAPS outcomes.

Effects of dopamine D1 modulation of the anterior cingulate cortex in a fear conditioning procedure (2015)
Journal Article
Pezze, M. A., Marshall, H., Domonkos, A., & Cassaday, H. J. (2015). Effects of dopamine D1 modulation of the anterior cingulate cortex in a fear conditioning procedure. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 65, https://doi.org/10.1016/j.pnpbp.2015.08.015

The anterior cingulate cortex (AC) component of the medial prefrontal cortex (mPFC) has been implicated in attention and working memory as measured by trace conditioning. Since dopamine (DA) is a key modulator of mPFC function, the present study eval... Read More about Effects of dopamine D1 modulation of the anterior cingulate cortex in a fear conditioning procedure.

Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex. (2015)
Journal Article
Cassaday, H., Pezze, M., Marshall, H., & Fone, K. (2015). Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex. European Neuropsychopharmacology, 25(11), 2145-2156. https://doi.org/10.1016/j.euroneuro.2015.07.018

© 2015 The Authors. Previous studies have shown that dopamine D1 receptor antagonists impair novel object recognition memory but the effects of dopamine D1 receptor stimulation remain to be determined. This study investigated the effects of the selec... Read More about Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex..

Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ⁹-tetrahydrocannabinol (THC) (2015)
Journal Article
Olarte-Sánchez, C., Valencia-Torres, L., Cassaday, H. J., Bradshaw, C., & Szabadi, E. (2015). Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ⁹-tetrahydrocannabinol (THC). Behavioural Processes, 113, https://doi.org/10.1016/j.beproc.2015.01.014

Rats’ performance on a progressive-ratio schedule maintained by sucrose (0.6 M, 50 μl) and corn oil (100%, 25 μl) reinforcers was assessed using a model derived from Killeen’s (1994) theory of scheduled-controlled behaviour, ‘Mathematical Principles... Read More about Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ⁹-tetrahydrocannabinol (THC).

Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex (2015)
Journal Article
Pezze, M. A., Marshall, H., & Cassaday, H. (in press). Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex. Psychopharmacology, 232(15), https://doi.org/10.1007/s00213-015-3903-4

Rationale: Trace conditioning may provide a behavioural model suitable to examine the maintenance of ‘on line’ information and its underlying neural substrates. Objectives: Experiment la was run to establish trace conditioning in a shortened proced... Read More about Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex.

Intraperitoneal sertraline and fluvoxamine increase contextual fear conditioning but are without effect on overshadowing between cues (2015)
Journal Article
Cassaday, H. J., & Thur, K. E. (2015). Intraperitoneal sertraline and fluvoxamine increase contextual fear conditioning but are without effect on overshadowing between cues. Pharmacology Biochemistry and Behavior, 129, https://doi.org/10.1016/j.pbb.2014.12.004

Treatment with selective serotonin reuptake inhibitors (SSRIs) can reduce contextual conditioning. Since contexts present a variety of potentially competing cues, impaired overshadowing may provide an account of such effects. The present study theref... Read More about Intraperitoneal sertraline and fluvoxamine increase contextual fear conditioning but are without effect on overshadowing between cues.

Ro 04-6790-induced cognitive enhancement: No effect in trace conditioning and novel object recognition procedures in adult male Wistar rats (2014)
Journal Article
Thur, K. E., Nelson, A. J., & Cassaday, H. J. (2014). Ro 04-6790-induced cognitive enhancement: No effect in trace conditioning and novel object recognition procedures in adult male Wistar rats. Pharmacology Biochemistry and Behavior, 127, https://doi.org/10.1016/j.pbb.2014.10.006

The evidence for cognitively enhancing effects of 5-hydroxytryptamine6 (5-HT6) receptor antagonists such as Ro 04-6790 is inconsistent and seems to depend on the behavioural test variant in use. Trace conditioning holds promise as a behavioral assay... Read More about Ro 04-6790-induced cognitive enhancement: No effect in trace conditioning and novel object recognition procedures in adult male Wistar rats.

From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations (2014)
Journal Article
Cassaday, H. J., Nelson, A. J., & Pezze, M. A. (2014). From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations. Frontiers in Neuroscience, 8(160), https://doi.org/10.3389/fnsys.2014.00160

Distinctions along the dorsal-ventral axis of medial prefrontal cortex (mPFC), between anterior cingulate (AC), prelimbic (PL) and infralimbic (IL) sub-regions, have been proposed on a variety of neuroanatomical and neurophysiological grounds. Conven... Read More about From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations.

Tourette-like behaviors in the normal population are associated with hyperactive/impulsive ADHD-like behaviors but do not relate to deficits in conditioned inhibition or response inhibition (2014)
Journal Article
Heym, N., Kantini, E., Checkley, H. L., & Cassaday, H. J. (2014). Tourette-like behaviors in the normal population are associated with hyperactive/impulsive ADHD-like behaviors but do not relate to deficits in conditioned inhibition or response inhibition. Frontiers in Psychology, 5(946), https://doi.org/10.3389/fpsyg.2014.00946

Attention-Deficit Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS) present as distinct conditions clinically; however, comorbidity and inhibitory control deficits have been proposed for both. Whilst such deficits have been studied widely with... Read More about Tourette-like behaviors in the normal population are associated with hyperactive/impulsive ADHD-like behaviors but do not relate to deficits in conditioned inhibition or response inhibition.

Do personality traits predict individual differences in excitatory and inhibitory learning? (2013)
Journal Article
He, Z., Cassaday, H. J., Bonardi, C., & Bibby, P. A. (2013). Do personality traits predict individual differences in excitatory and inhibitory learning?. Frontiers in Psychology, 4(245), https://doi.org/10.3389/fpsyg.2013.00245

Conditioned inhibition (CI) is demonstrated in classical conditioning when a stimulus is used to signal the omission of an otherwise expected outcome. This basic learning ability is involved in a wide range of normal behavior – and thus its disruptio... Read More about Do personality traits predict individual differences in excitatory and inhibitory learning?.

Paradoxical effects of low dose MDMA on latent inhibition in the rat (2013)
Journal Article
Nelson, A. J., Thur, K. E., Marsden, C., & Cassaday, H. J. (2013). Paradoxical effects of low dose MDMA on latent inhibition in the rat. Neuropharmacology, 67(4), https://doi.org/10.1016/j.neuropharm.2012.11.012

The cognitive effects of MDMA ('Ecstasy') are controversial, particularly in the case of acute administration of low doses. Latent inhibition (LI) refers to the reduction in conditioning to a stimulus that has received non-reinforced pre-exposure, an... Read More about Paradoxical effects of low dose MDMA on latent inhibition in the rat.

Dopamine D1 receptor involvement in latent inhibition and overshadowing (2012)
Journal Article
Nelson, A. J., Thur, K. E., & Cassaday, H. J. (2012). Dopamine D1 receptor involvement in latent inhibition and overshadowing. International Journal of Neuropsychopharmacology, 15(10), https://doi.org/10.1017/S1461145711001751

Latent inhibition (LI) manifests as poorer conditioning to a stimulus that has previously been experienced without consequence. There is good evidence of dopaminergic modulation of LI, as the effect is reliably disrupted by the indirect dopamine (DA... Read More about Dopamine D1 receptor involvement in latent inhibition and overshadowing.

When to hold that thought: an experimental study showing reduced inhibition of pre-trained associations in schizophrenia (2012)
Journal Article
He, Z., Cassaday, H. J., Park, S. B. G., & Bonardi, C. (2012). When to hold that thought: an experimental study showing reduced inhibition of pre-trained associations in schizophrenia. PLoS ONE, 7(7), Article e42175. https://doi.org/10.1371/journal.pone.0042175

Schizophrenia encompasses a wide variety of cognitive dysfunctions, a number of which can be understood as deficits of inhibition. To date, no research has examined ‘conditioned inhibition’ in schizophrenia - the ability of a stimulus that signal... Read More about When to hold that thought: an experimental study showing reduced inhibition of pre-trained associations in schizophrenia.

Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli (2012)
Journal Article
Nelson, A. J., Thur, K. E., Marsden, C. A., & Cassaday, H. J. (2012). Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli. International Journal of Neuropsychopharmacology, 15(4), https://doi.org/10.1017/S1461145711000599

There is good evidence that forebrain serotonergic systems modulate cognitive flexibility. Latent inhibition (LI) is a cross-species phenomenon which manifests as poor conditioning to a stimulus that has previously been experienced without consequenc... Read More about Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli.

Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing (2012)
Journal Article
Nelson, A. J., Thur, K. E., Marsden, C., & Cassaday, H. J. (2012). Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing. Journal of Psychopharmacology, 25(12), https://doi.org/10.1177/0269881110389211

Latent inhibition (LI) is demonstrated when non-reinforced pre-exposure to a to-be-conditioned stimulus retards later learning. Learning is similarly retarded in overshadowing, in this case using the relative intensity of competing cues to manipulate... Read More about Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing.

A clozapine-like effect of cyproheptadine on progressive ratio schedule performance (2011)
Journal Article
Olarte-Sánchez, C., Valencia Torres, L., Cassaday, H. J., Body, S., Bradshaw, C., Szabadi, E., & Goudie, A. (2012). A clozapine-like effect of cyproheptadine on progressive ratio schedule performance. Journal of Psychopharmacology, 26(6), 857-870. https://doi.org/10.1177/0269881111408961

The atypical antipsychotic drug clozapine has multiple pharmacological actions, some of which, including 5-hydroxytryptamine (5-HT2) and histamine (H1) receptor antagonist effects, are shared by the non-selective 5-HT receptor antagonist cyproheptadi... Read More about A clozapine-like effect of cyproheptadine on progressive ratio schedule performance.

Catecholaminergic depletion in nucleus accumbens enhances trace conditioning (2011)
Journal Article
Nelson, A. J., Thur, K. E., Spicer, C., Marsden, C., & Cassaday, H. J. (2011). Catecholaminergic depletion in nucleus accumbens enhances trace conditioning. Advances in Medical Sciences, 56(1), https://doi.org/10.2478/v10039-011-0014-2

Purpose: To examine the effect of dopamine depletion in nucleus accumbens on trace conditioning; to distinguish the role of core and shell sub-regions, as far as possible. Material/Methods: 6-hydroxydopamine was used to lesion dopamine terminals with... Read More about Catecholaminergic depletion in nucleus accumbens enhances trace conditioning.

The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects (2011)
Journal Article
Nelson, A. J., Cooper, M. T., Thur, K. E., Marsden, C. A., & Cassaday, H. J. (2011). The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects. Behavioral Neuroscience, 125(3), https://doi.org/10.1037/a0023337

There is good evidence that the medial prefrontal cortex (mPFC) is involved in different aspects of recognition memory. However, the mPFC is a heterogeneous structure, and the contribution of the prelimbic (PL) and infralimbic (IL) cortices to recogn... Read More about The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects.

Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition (2011)
Journal Article
Nelson, A. J., Thur, K. E., Horsley, R., Spicer, C., Marsden, C., & Cassaday, H. J. (2011). Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition. Pharmacology Biochemistry and Behavior, 98(1), https://doi.org/10.1016/j.pbb.2010.11.025

Latent inhibition (LI) manifests as poorer conditioning to a CS that has previously been presented without consequence. There is some evidence that LI can be potentiated by reduced mesoaccumbal dopamine (DA) function but the locus within the nucleus... Read More about Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition.