A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection

Abedin, Asiya; Mohammed, Imran; Hopkinson, Andrew; Dua, Harminder S.

doi:10.1167/iovs.07-0645

All Outputs (65)

Signalling pathways involved in ribonuclease-7 expression (2010)
Journal Article
Mohammed, I., Yeung, A., Abedin, A., Hopkinson, A., & Dua, H. S. (2011). Signalling pathways involved in ribonuclease-7 expression. Cellular and Molecular Life Sciences, 68(11), 1941-1952. https://doi.org/10.1007/s00018-010-0540-2

Antimicrobial peptides are host defence molecules that play a potential role in preventing infection at the epithelial surfaces. Ribonuclease (RNase)-7 has been shown to possess a broad spectrum of microbicidal activity against various pathogens. Her... Read More about Signalling pathways involved in ribonuclease-7 expression.

Localization and Gene Expression of Human β-Defensin 9 at the Human Ocular Surface Epithelium (2010)
Journal Article
Mohammed, I., Suleman, H., Otri, A. M., Kulkarni, B. B., Chen, P., Hopkinson, A., & Dua, H. S. (2010). Localization and Gene Expression of Human β-Defensin 9 at the Human Ocular Surface Epithelium. Investigative Ophthalmology & Visual Science, 51(9), 4677-4682. https://doi.org/10.1167/iovs.10-5334

Purpose: Antimicrobial peptides (AMPs) are multifunctional host defense molecules. Human β-defensin 9 (HBD9) has previously been shown to be downregulated during ocular surface (OS) infection or inflammation. Here, the authors aimed to study localiz... Read More about Localization and Gene Expression of Human β-Defensin 9 at the Human Ocular Surface Epithelium.

Architecture and distribution of human corneal nerves (2009)
Journal Article
Al-Aqaba, M. A., Fares, U., Suleman, H., Lowe, J., & Dua, H. S. (2010). Architecture and distribution of human corneal nerves. British Journal of Ophthalmology, 94(6), 784-789. https://doi.org/10.1136/bjo.2009.173799

Epidermal Growth Factor Variations in Amniotic Membrane Used for Ex Vivo Tissue Constructs (2009)
Journal Article
Gicquel, J.-J., Dua, H. S., Brodie, A., Mohammed, I., Suleman, H., Lazutina, E., James, D. K., & Hopkinson, A. (2009). Epidermal Growth Factor Variations in Amniotic Membrane Used for Ex Vivo Tissue Constructs. Tissue Engineering Part A, 15(8), 1919-1927. https://doi.org/10.1089/ten.tea.2008.0432

Introduction: The amniotic membrane (AM) is used for engineering ex vivo tissue constructs used in ocular surface reconstruction. Epidermal growth factor (EGF) content of the AM is believed to play a key role in supporting corneal epithelial cell exp... Read More about Epidermal Growth Factor Variations in Amniotic Membrane Used for Ex Vivo Tissue Constructs.

A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection (2008)
Journal Article
Abedin, A., Mohammed, I., Hopkinson, A., & Dua, H. S. (2008). A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection. Investigative Ophthalmology & Visual Science, 49(1), 28-33. https://doi.org/10.1167/iovs.07-0645

PURPOSE: Antimicrobial peptides (AMPs) are cationic host defense peptides with microbicidal and cell-signaling properties. They show promise as potential therapeutic agents. In the present study, a beta-defensin AMP gene was isolated from the ocular... Read More about A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection.