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Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection (2016)
Journal Article
He, J., Ma, J., Elsheikha, H. M., Song, H., Huang, S., & Zhu, X. (2016). Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection. Parasites and Vectors, 9(1), Article 427. https://doi.org/10.1186/s13071-016-1716-x

Background

Toxoplasma gondii is a worldwide spread pathogen which can infect all tissues of its host. The transcriptomic responses of infected brain and spleen have been reported. However, our knowledge of the global transcriptomic change in infec... Read More about Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection.

Global iTRAQ-based proteomic profiling of Toxoplasma gondii oocysts during sporulation (2016)
Journal Article
Zhou, C.-X., Zhu, X.-Q., Elsheikha, H. M., He, S., Li, Q., Zhou, D.-H., & Suo, X. (2016). Global iTRAQ-based proteomic profiling of Toxoplasma gondii oocysts during sporulation. Journal of Proteomics, 148, 12-19. https://doi.org/10.1016/j.jprot.2016.07.010

Toxoplasma gondii is a medically and economically important protozoan parasite. However, the molecular mechanisms of its sporulation remain largely unknown. Here, we applied iTRAQ coupled with 2D LC–MS/MS proteomic analysis to investigate the proteom... Read More about Global iTRAQ-based proteomic profiling of Toxoplasma gondii oocysts during sporulation.

Updates on feline aelurostrongylosis and research priorities for the next decade (2016)
Journal Article
Elsheikha, H. M., Schnyder, M., Traversa, D., Di Cesare, A., Wright, I., & Lacher, D. W. (2016). Updates on feline aelurostrongylosis and research priorities for the next decade. Parasites and Vectors, 9, Article 389. https://doi.org/10.1186/s13071-016-1671-6

Feline aelurostrongylosis, caused by the metastrongyloid nematode Aelurostrongylus abstrusus, is an important gastropod-borne parasitic lung disease in cats. Infection with A. abstrusus is widespread globally, but the increasing awareness of this par... Read More about Updates on feline aelurostrongylosis and research priorities for the next decade.

Proteomic profiling of mouse liver following acute Toxoplasma gondii infection (2016)
Journal Article
He, J.-J., Ma, J., Elsheikha, H. M., Song, H.-Q., Zhou, D.-H., & Zhu, X.-Q. (2016). Proteomic profiling of mouse liver following acute Toxoplasma gondii infection. PLoS ONE, 11(3), 1-15. https://doi.org/10.1371/journal.pone.0152022

© 2016 He et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credite... Read More about Proteomic profiling of mouse liver following acute Toxoplasma gondii infection.

Tracing amino acid exchange during host-pathogen interaction by combined stable-isotope time-resolved Raman spectral imaging (2016)
Journal Article
Naemat, A., Elsheikha, H. M., Boiter, R., & Notingher, I. (2016). Tracing amino acid exchange during host-pathogen interaction by combined stable-isotope time-resolved Raman spectral imaging. Scientific Reports, 6, Article 20811. https://doi.org/10.1038/srep20811

This study investigates the temporal and spatial interchange of the aromatic amino acid phenylalanine (Phe) between human retinal pigment epithelial cell line (ARPE-19) and tachyzoites of the apicomplexan protozoan parasite Toxoplasma gondii (T. gond... Read More about Tracing amino acid exchange during host-pathogen interaction by combined stable-isotope time-resolved Raman spectral imaging.

Metabolomic Profiling of Mice Serum during Toxoplasmosis Progression Using Liquid Chromatography-Mass Spectrometry (2016)
Journal Article
Zhou, C., Zhou, D. -., Elsheikha, H. M., Zhao, Y., Suo, X., & Zhu, X. (2016). Metabolomic Profiling of Mice Serum during Toxoplasmosis Progression Using Liquid Chromatography-Mass Spectrometry. Scientific Reports, 6, Article 19557. https://doi.org/10.1038/srep19557

Better understanding of the molecular changes associated with disease is essential for identifying new routes to improved therapeutics and diagnostic tests. The aim of this study was to investigate the dynamic changes in the metabolic profile of mous... Read More about Metabolomic Profiling of Mice Serum during Toxoplasmosis Progression Using Liquid Chromatography-Mass Spectrometry.

Global Metabolomic Profiling of Mice Brains following Experimental Infection with the Cyst-Forming Toxoplasma gondii (2015)
Journal Article
Zhou, C.-X., Elsheikha, H. M., Zhou, D.-H., Liu, G.-X., Suo, X., & Zhu, X.-Q. (2015). Global Metabolomic Profiling of Mice Brains following Experimental Infection with the Cyst-Forming Toxoplasma gondii. PLoS ONE, 10(10), Article e0139635. https://doi.org/10.1371/journal.pone.0139635

© 2015 Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credi... Read More about Global Metabolomic Profiling of Mice Brains following Experimental Infection with the Cyst-Forming Toxoplasma gondii.

Analysis of interaction between the apicomplexan protozoan Toxoplasma gondii and host cells using label-free Raman spectroscopy (2014)
Journal Article
Naemat, A., Elsheikha, H. M., Al-sandaqchib, A., Kong, K., Ghita, A., & Notingher, I. (2015). Analysis of interaction between the apicomplexan protozoan Toxoplasma gondii and host cells using label-free Raman spectroscopy. Analyst, 140(3), 756-764. https://doi.org/10.1039/c4an01810a

Label-free imaging using Raman micro-spectroscopy (RMS) was used to characterize the spatio-temporal molecular changes of T. gondii tachyzoites and their host cell microenvironment. Raman spectral maps were recorded from isolated T. gondii tachyzoite... Read More about Analysis of interaction between the apicomplexan protozoan Toxoplasma gondii and host cells using label-free Raman spectroscopy.

Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier (2014)
Journal Article
Elmorsy, E., Elzalabany, L. M., Elsheikha, H. M., & Smith, P. A. (2014). Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier. Brain Research, 1583(1), 255-268. https://doi.org/10.1016/j.brainres.2014.08.011

© 2014 Elsevier B.V. All rights reserved. Although the mechanisms of action of antipsychotics (APs) on neuronal function are well understood, very little is known about their effects on cells of the blood-brain barrier (BBB); one function of which is... Read More about Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier.

Effects of Neospora caninum infection on brain microvascular endothelial cells bioenergetics (2013)
Journal Article
Elsheikha, H. M., McKinlay, C. L., Elsaied, N. A., & Smith, P. A. (2013). Effects of Neospora caninum infection on brain microvascular endothelial cells bioenergetics. Parasites and Vectors, 6(24), https://doi.org/10.1186/1756-3305-6-24

Background: The brain is the most commonly affected organ during Neospora caninum infection but the mechanisms utilized by this protozoan parasite for traversal of the blood–brain barrier (BBB) are not yet understood. Herein, we investigate the cellu... Read More about Effects of Neospora caninum infection on brain microvascular endothelial cells bioenergetics.

Lipidomic analysis of serum from horses with strongyle infection
Journal Article
Lamb, J., Hallowell, G. D., Harris, P., Xing-Quan, Z., & Elsheikha, H. M. Lipidomic analysis of serum from horses with strongyle infection. Journal of Veterinary Science and Technology, 3(6), Article 122. https://doi.org/10.4172/2157-7579.1000122

The development of techniques capable of accurate diagnosis of strongyle infections is at the forefront of research in equine parasitology. The aim of this study was to evaluate the potential, for using lipidomics in the diagnosis of strongyle infect... Read More about Lipidomic analysis of serum from horses with strongyle infection.