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Novel Entamoeba findings in nonhuman primates (2018)
Journal Article
Elsheikha, H. M., Regan, C. S., & Clark, C. G. (2018). Novel Entamoeba findings in nonhuman primates. Trends in Parasitology, 34(4), https://doi.org/10.1016/j.pt.2017.12.008

In addition to well-known human-infecting species, Entamoeba species not found in humans have been identified recently in nonhuman primates (NHPs). Importantly, it has become clear that the organism identified as Entamoeba histolytica in NHPs is usua... Read More about Novel Entamoeba findings in nonhuman primates.

Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry (2018)
Journal Article
Zhou, C.-X., Cong, W., Chen, X.-Q., He, S.-Y., Elsheikha, H. M., & Zhu, X.-Q. (2018). Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02612

Toxoplasma gondii is an obligate intracellular parasite causing severe diseases in immunocompromised individuals and congenitally infected neonates, such as toxoplasmosis encephalitis and toxoplasmic chorioretinitis. This study aimed to determine whe... Read More about Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry.

Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica (2017)
Journal Article
Zhang, F.-K., Hou, J.-L., Guo, A.-J., Tian, A.-L., Shi, W., Sheng, Z.-A., …Zhu, X.-Q. (2018). Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica. Molecular Immunology, 94, https://doi.org/10.1016/j.molimm.2017.12.007

Infection of ruminants and humans with Fasciola gigantica is attracting increasing attention due to its economic impact and public health significance. However, little is known of innate immune responses during F. gigantica infection. Here, we invest... Read More about Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica.

Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes (2017)
Journal Article
Shi, W., Wei, Z.-Y., Elsheikha, H. M., Zhang, F.-K., Sheng, Z.-A., Lu, K.-J., …Zhu, X.-Q. (2017). Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes. Parasites and Vectors, 10(1), Article 602. https://doi.org/10.1186/s13071-017-2538-1

Background Determining the mechanisms involved in the immune-pathogenesis of the tropical liver fluke, Fasciola gigantica, is crucial to the development of any effective therapeutic intervention. Here, we examined the differential gene expression... Read More about Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes.

Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China (2017)
Journal Article
Tian, A., Gu, Y.-L., Zhou, N., Cong, W., Liu, G.-X., Elsheikha, H. M., & Zhu, X.-Q. (in press). Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China. Infectious Diseases of Poverty, 6, Article 153. https://doi.org/10.1186/s40249-017-0367-2

Background: There is accumulating evidence for an increased susceptibility to infection in patients with arthritis. We sought to understand the epidemiology of Toxoplasma gondii infection in arthritis patients in eastern China, given the paucity of d... Read More about Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China.

Serum levels of cytokines in water buffaloes experimentally infected with Fasciola gigantica (2017)
Journal Article
Zhang, F.-K., Guo, A.-J., Hou, J.-L., Sun, M.-M., Sheng, Z.-A., Zhang, X.-X., …Zhu, X.-Q. (2017). Serum levels of cytokines in water buffaloes experimentally infected with Fasciola gigantica. Veterinary Parasitology, 244, 97-101. https://doi.org/10.1016/j.vetpar.2017.07.028

Fasciola gigantica infection in water buffaloes causes significant economic losses especially 27 in developing countries. Although modulation of the host immune response by cytokine 28 neutralization or vaccination is a promising approach to control... Read More about Serum levels of cytokines in water buffaloes experimentally infected with Fasciola gigantica.

Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis (2017)
Journal Article
Chen, X.-Q., Zhou, C.-X., Elsheikha, H. M., He, S., Hu, G.-X., & Zhu, X.-Q. (2017). Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis. Parasites and Vectors, 10(1), Article 339. https://doi.org/10.1186/s13071-017-2282-6

Background Toxoplasma gondii, a common opportunistic protozoan, is a leading cause of illness and mortality among immunosuppressed individuals and during congenital infections. Current therapeutic strategies for toxoplasmosis are not fully effecti... Read More about Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis.

Toxoplasma gondii infection in farmed wild boars (Sus scrofa) in three cities of northeast China (2017)
Journal Article
Bai, M.-J., Zou, Y., Elsheikha, H. M., Ma, J.-G., Zheng, W.-B., Zhao, Q., …Zhu, X.-Q. (2017). Toxoplasma gondii infection in farmed wild boars (Sus scrofa) in three cities of northeast China. Foodborne Pathogens and Disease, 14(7), 379-385. https://doi.org/10.1089/fpd.2016.2260

The apicomplexan protozoan parasite Toxoplasma gondii is a widely distributed etiological agent of foodborne illness. This parasite can cause production losses in livestock and serious disease in humans through consumption of contaminated meat. Pig m... Read More about Toxoplasma gondii infection in farmed wild boars (Sus scrofa) in three cities of northeast China.

Comparative proteomic analysis of virulent and avirulent strains of Toxoplasma gondii reveals strain-specific patterns (2017)
Journal Article
Zhou, D.-H., Wang, Z.-X., Zhou, C.-X., He, S., Elsheikha, H. M., & Zhu, X.-Q. (2017). Comparative proteomic analysis of virulent and avirulent strains of Toxoplasma gondii reveals strain-specific patterns. Oncotarget, 8(46), https://doi.org/10.18632/oncotarget.19077

Research exploring the proteome of Toxoplasma gondii oocysts has gained momentum over the past few years. However, little is known about the oocyst’s protein repertoires that contribute to differential virulence among T. gondii strains. Here, we used... Read More about Comparative proteomic analysis of virulent and avirulent strains of Toxoplasma gondii reveals strain-specific patterns.

Immunization with Toxoplasma gondii GRA17 deletion mutant induces partial protection and survival in challenged mice (2017)
Journal Article
Wang, J., Elsheikha, H. M., Zhu, W., Chen, K., Li, T., Yue, D., …Zhu, X. (2017). Immunization with Toxoplasma gondii GRA17 deletion mutant induces partial protection and survival in challenged mice. Frontiers in Immunology, 8, Article 730. https://doi.org/10.3389/fimmu.2017.00730

Toxoplasmosis remains a world-threatening disease largely because of the lack of a fully effective vaccine. Here, we created a ΔGRA17 mutant by disrupting the virulence factor GRA17 using CRISPR-Cas9 method. Then, we tested whether ΔGRA17 tachyzoites... Read More about Immunization with Toxoplasma gondii GRA17 deletion mutant induces partial protection and survival in challenged mice.

Proteomic differences between developmental stages of Toxoplasma gondii revealed by iTRAQ-based quantitative proteomics (2017)
Journal Article
Wang, Z.-X., Zhou, C.-X., Elsheikha, H. M., He, S., Zhou, D.-H., & Zhu, X.-Q. (in press). Proteomic differences between developmental stages of Toxoplasma gondii revealed by iTRAQ-based quantitative proteomics. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.00985

Toxoplasma gondii has a complex two-host life-cycle between intermediate host and definitive host. Understanding proteomic variations across the life-cycle stages of T. gondii may improve the understanding of molecular adaption mechanism of T. gondii... Read More about Proteomic differences between developmental stages of Toxoplasma gondii revealed by iTRAQ-based quantitative proteomics.

Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection (2017)
Journal Article
Cong, W., Zhang, X.-X., He, J.-J., Li, F.-C., Elsheikha, H. M., & Zhu, X.-Q. (2017). Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection. Oncotarget, 8(15), https://doi.org/10.18632/oncotarget.16108

Although microRNAs (miRNAs) play an important role in liver homeostasis, the extent to which they can be altered by Toxoplasma gondii infection is unknown. Here, we utilized small RNA sequencing and bioinformatic analyses to characterize miRNA expres... Read More about Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection.

De novo transcriptome sequencing and analysis of the juvenile and adult stages of Fasciola gigantica (2017)
Journal Article
Zhang, X.-X., Cong, W., Elsheikha, H. M., Liu, G.-H., Ma, J.-G., Huang, W.-Y., …Zhu, X.-Q. (2017). De novo transcriptome sequencing and analysis of the juvenile and adult stages of Fasciola gigantica. Infection, Genetics and Evolution, 51, 33-40. https://doi.org/10.1016/j.meegid.2017.03.007

Fasciola gigantica is regarded as the major liver fluke causing fasciolosis in livestock in tropical countries. Despite the significant economic and public health impacts of F. gigantica there are few studies on the pathogenesis of this parasite and... Read More about De novo transcriptome sequencing and analysis of the juvenile and adult stages of Fasciola gigantica.

Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica (2017)
Journal Article
Zhang, F.-K., Zhang, X.-X., Elsheikha, H. M., He, J.-J., Sheng, Z.-A., Zheng, W.-B., …Zhu, X.-Q. (2017). Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica. Parasites and Vectors, 10(1), Article 56. https://doi.org/10.1186/s13071-017-1990-2

Background Fasciola gigantica, the tropical liver fluke, infects buffaloes in Asian and African countries and causes significant economic losses and poses public health threat in these countries. However, little is known of the transcriptional respo... Read More about Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica.

Functional characterization of rhoptry kinome in the virulent toxoplasma gondii RH strain (2017)
Journal Article
Wang, J.-L., Li, T.-T., Elsheikha, H. M., Chen, K., Zhu, W.-N., Yue, D.-M., …Huang, S.-Y. (in press). Functional characterization of rhoptry kinome in the virulent toxoplasma gondii RH strain. Frontiers in Microbiology, 8, Article 84. https://doi.org/10.3389/fmicb.2017.00084

Toxoplasma gondii is an obligatory intracellular apicomplexan protozoan which can infect any warm-blooded animal and causes severe diseases in immunocompromised individuals or infants infected in utero. The survival and success of this parasite requi... Read More about Functional characterization of rhoptry kinome in the virulent toxoplasma gondii RH strain.

Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system (2017)
Journal Article
Liu, Q., Li, F.-C., Elsheikha, H. M., Sun, M.-M., & Zhu, X.-Q. (2017). Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system. Parasites and Vectors, 10(1), https://doi.org/10.1186/s13071-016-1943-1

Background Toxoplasma gondii, an obligate intracellular protozoan parasite, possesses the remarkable ability to co-opt host cell machinery in order to maintain its intracellular survival. This parasite can modulate signaling pathways of its host t... Read More about Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system.

STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways (2016)
Journal Article
Ho, J., Pelzel, C., Begitt, A., Mee, M., Elsheikha, H. M., Scott, D. J., & Vinkemeier, U. (2016). STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways. PLoS Biology, 14(10), 1-27. https://doi.org/10.1371/journal.pbio.2000117

STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, the human and murine STAT2-deficient phenotypes suggest important additional and currently unidentified type 1 IF... Read More about STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways.

Acanthamoeba castellanii : A new high-throughput method for drug screening in vitro (2016)
Journal Article
Ortega-Rivas, A., Padrón, J. M., Valladares, B., & Elsheikha, H. M. (2016). Acanthamoeba castellanii : A new high-throughput method for drug screening in vitro. Acta Tropica, 164, 95-99. https://doi.org/10.1016/j.actatropica.2016.09.006

Despite significant public health impact, there is no specific antiprotozoal therapy for prevention and treatment of Acanthamoeba castellanii infection. There is a need for new and efficient anti-Acanthamoeba drugs that are less toxic and can reduce... Read More about Acanthamoeba castellanii : A new high-throughput method for drug screening in vitro.

Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection (2016)
Journal Article
He, J., Ma, J., Elsheikha, H. M., Song, H., Huang, S., & Zhu, X. (2016). Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection. Parasites and Vectors, 9(1), Article 427. https://doi.org/10.1186/s13071-016-1716-x

Background Toxoplasma gondii is a worldwide spread pathogen which can infect all tissues of its host. The transcriptomic responses of infected brain and spleen have been reported. However, our knowledge of the global transcriptomic change in infec... Read More about Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection.