Skip to main content

Research Repository

Advanced Search

All Outputs (186)

Cost-effectiveness of risk-stratified blood-test monitoring strategies for adults with inflammatory conditions (2025)
Journal Article
Stevenson, M., Nakafero, G., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., & Abhishek, A. (in press). Cost-effectiveness of risk-stratified blood-test monitoring strategies for adults with inflammatory conditions. Rheumatology. https://academic.oup.com/rheumatology

Objectives: To assess the cost-effectiveness of extending the interval between monitoring blood-tests beyond three monthly intervals during established treatment of adults prescribed low-dose weekly methotrexate (≤ 25 mg/week), leflunomide, or sulfas... Read More about Cost-effectiveness of risk-stratified blood-test monitoring strategies for adults with inflammatory conditions.

Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma and Perspectives on the Future Applications of Advanced Technologies (2025)
Journal Article
Gaston, K., Mohammad, A., Venkatachalapathy, S. V., Notingher, I., Gordon, G. S. D., Arora, A., Rawson, F. J., Grove, J. I., Mukherjee, A., Gomez, D., Jayaraman, P.-S., & Aithal, G. P. (2025). Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma and Perspectives on the Future Applications of Advanced Technologies. Cancers, 17(14), 2301. https://doi.org/10.3390/cancers17142301

In the management of cholangiocarcinoma, effective biliary drainage and accurate diagnosis are vital to allow further treatment. Confirmation of tissue diagnosis and molecular characterization is also required to guide future treatment options includ... Read More about Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma and Perspectives on the Future Applications of Advanced Technologies.

Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis (2025)
Journal Article
Quammie, S., Crooks, C., Aliyu, A., Aithal, G. P., & Aravinthan, A. D. (2025). Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis. Pancreatology, 25(4), 516-527. https://doi.org/10.1016/j.pan.2025.05.003

Introduction: Chronic pancreatitis (CP) is a known risk factor for pancreatic cancer; however its association to extra pancreatic (EP) cancers remains inadequately explored. The aim of this systematic review is to investigate the evidence for CP as a... Read More about Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis.

Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury (2025)
Journal Article
Ji, C., Kumpf, S., Qian, J., Federspiel, J. D., Sheehan, M., Capunitan, D., Atallah, E., Astbury, S., Arat, S., Oziolor, E., Ocana, M. F., Ramaiah, S. K., Grove, J., Aithal, G. P., & Lanz, T. A. (2025). Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury. Cancer Immunology, Immunotherapy, 74(6), 190. https://doi.org/10.1007/s00262-025-04033-z

Immune checkpoint inhibitors (ICI) targeting CTLA-4 and PD-1 have shown remarkable antitumor efficacy, but can also cause immune-related adverse events, including checkpoint inhibitor-induced liver injury (ChILI). This multi-omic study aimed to inves... Read More about Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury.

The development of a food-group, tree classification method and its use in exploring dietary associations with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) and other health-related outcomes in a UK Population (2025)
Journal Article
Alawadi, A. A., Vijay, A., Grove, J. I., Taylor, M. A., & Aithal, G. P. (2025). The development of a food-group, tree classification method and its use in exploring dietary associations with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) and other health-related outcomes in a UK Population. Metabolism Open, 25, 100351. https://doi.org/10.1016/j.metop.2025.100351

Background
Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) affects up to one in five people in the UK, with persistent overeating and a sedentary lifestyle being significant risk factors. Exploring dietary patterns at a food level i... Read More about The development of a food-group, tree classification method and its use in exploring dietary associations with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) and other health-related outcomes in a UK Population.

Chronic pancreatitis: a case ascertainment study (2025)
Journal Article
Quammie, S., Rashid, A., Munya, R., Nicholson, E. S., Clarke, C., Venkatachalapathy, S. V., Crooks, C. J., Aithal, G. P., & Aravinthan, A. D. (2025). Chronic pancreatitis: a case ascertainment study. Frontline Gastroenterology, 16(4), 300-307. https://doi.org/10.1136/flgastro-2024-102786

Background Chronic pancreatitis (CP) is a debilitating condition, characterised by chronic inflammation and fibrosis of the pancreas. The population frequency of CP is poorly understood. Therefore, we used a broad pragmatic approach to estimate the f... Read More about Chronic pancreatitis: a case ascertainment study.

Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review (2024)
Journal Article
Subhani, M., Dhanda, A., King, J. A., Warren, F. C., Creanor, S., Davies, M. J., Eldeghaidy, S., Bawden, S., Gowland, P. A., Bataller, R., Greenwood, J., Kaar, S., Bhala, N., & Aithal, G. P. (2024). Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review. eClinicalMedicine, 78, 102920. https://doi.org/10.1016/j.eclinm.2024.102920

Background
Despite the availability of various pharmacological and behavioural interventions, alcohol-related mortality is rising. This systematic review aimed to critically evaluate the existing literature on the association between glucagon-like p... Read More about Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review.

Structuring white rice with gellan gum reduces the glycemic response in healthy humans (2024)
Journal Article
Alshammari, N. A., Riches, K., Muttakin, S., Hoad, C. L., Strkalj, L., Gouseti, O., Bakalis, S., Lovegrove, A., Spiller, R. C., Gowland, P. A., Aithal, G. P., Yakubov, G. E., Taylor, M. A., & Marciani, L. (2024). Structuring white rice with gellan gum reduces the glycemic response in healthy humans. Food Research International, 196, 115090. https://doi.org/10.1016/j.foodres.2024.115090

White rice has a high glycemic index and its consumption has been linked to an increased risk of developing type-2 diabetes mellitus, increased diabetes associated complications and obesity. In recent in vitro studies we have shown that addition of f... Read More about Structuring white rice with gellan gum reduces the glycemic response in healthy humans.

Glycated haemoglobin is a major predictor of disease severity in patients with NAFLD (2024)
Journal Article
Colosimo, S., Miller, H., Koutoukidis, D. A., Marjot, T., Tan, G. D., Harman, D. J., Aithal, G. P., Manousou, P., Forlano, R., Parker, R., Sheridan, D. A., Newsome, P. N., Alazawi, W., Cobbold, J. F., & Tomlinson, J. W. (2024). Glycated haemoglobin is a major predictor of disease severity in patients with NAFLD. Diabetes Research and Clinical Practice, 217, 111820. https://doi.org/10.1016/j.diabres.2024.111820

Objectives: Currently, non-invasive scoring systems to stage the severity of non-alcoholic fatty liver disease (NAFLD) do not consider markers of glucose control (glycated haemoglobin, HbA1c); this study aimed to define the relationship between HbA1c... Read More about Glycated haemoglobin is a major predictor of disease severity in patients with NAFLD.

Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training (2024)
Journal Article
Willis, S. A., Malaikah, S., Bawden, S. J., Sherry, A. P., Sargeant, J. A., Coull, N. A., Bradley, C. R., Rowlands, A., Naim, I., Ennequin, G., Yates, T., Waheed, G., Gowland, P., Stensel, D. J., Webb, D. R., Davies, M. J., Aithal, G. P., & King, J. A. (2024). Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training. Diabetes, Obesity and Metabolism, 26(9), 4030-4042. https://doi.org/10.1111/dom.15755

Aims: To examine the impact of impaired glycaemic regulation (IGR) and exercise training on hepatic lipid composition in men with metabolic dysfunction‐associated steatotic liver disease (MASLD). Materials and Methods: In Part A (cross‐sectional desi... Read More about Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training.

A polygenic risk score for alcohol-related cirrhosis among heavy drinkers with European ancestry (2024)
Journal Article
Schwantes-An, T.-H., Whitfield, J., Aithal, G., Atkinson, S., Bataller, R., Botwin, G., Chalasani, N., Cordell, H., Daly, A., Darlay, R., Day, C., Eyer, F., Foroud, T., Gawrieh, S., Gleeson, D., Goldma, D., Haber, P., Jacquet, J.-M., Lammert, C., …GenomALC Consortium, G. C. (2024). A polygenic risk score for alcohol-related cirrhosis among heavy drinkers with European ancestry. Hepatology Communications, 8(6), e0431. https://doi.org/10.1097/HC9.0000000000000431

Background & Aims: Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS for alcohol-related cirrhosis by comparing SNPs am... Read More about A polygenic risk score for alcohol-related cirrhosis among heavy drinkers with European ancestry.

Vascular adhesion protein-1 blockade in primary sclerosing cholangitis: Open-label, multicenter, single-arm, phase II trial (2024)
Journal Article
Hirschfield, G. M., Arndtz, K., Kirkham, A., Chen, Y.-Y., Fox, R., Rowe, A., Douglas-Pugh, J., Thorburn, D., Barnes, E., Aithal, G. P., Hull, D., Bhandal, K., Olsen, K., Woodward, P., Lax, S., Newsome, P., Smith, D. J., Kallio, A., Adams, D. H., …Weston, C. J. (2024). Vascular adhesion protein-1 blockade in primary sclerosing cholangitis: Open-label, multicenter, single-arm, phase II trial. Hepatology Communications, 8(5), e0426. https://doi.org/10.1097/hc9.0000000000000426

Background:
Primary sclerosing cholangitis is a progressive inflammatory liver disease characterized by biliary and liver fibrosis. Vascular adhesion protein-1 (VAP-1) is important in the inflammatory process driving liver fibrosis. We evaluated th... Read More about Vascular adhesion protein-1 blockade in primary sclerosing cholangitis: Open-label, multicenter, single-arm, phase II trial.

Health professional attitudes and perceptions of prehabilitation and nutrition before haematopoietic cell transplantation (2024)
Journal Article
Miller, L. J., Halliday, V., Snowden, J. A., Aithal, G. P., Lee, J., & Greenfield, D. M. (2024). Health professional attitudes and perceptions of prehabilitation and nutrition before haematopoietic cell transplantation. Journal of Human Nutrition and Dietetics, 37(4), 1007-1021. https://doi.org/10.1111/jhn.13315

Background
Nutritional prehabilitation may improve haematopoietic cell transplantation (HCT) outcomes, although little evidence exists. The present study aimed to understand healthcare professional (HCP) perceptions of prehabilitation and nutritiona... Read More about Health professional attitudes and perceptions of prehabilitation and nutrition before haematopoietic cell transplantation.

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Maxwell, J. R., Bingham, S., Vedhara, K., & Abhishek, A. (2025). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, 64(3), 969-975. https://doi.org/10.1093/rheumatology/keae175

Objective
To explore the acceptability of an individualized risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s).

Methods
Ad... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

An optimized short‐term steroid therapy for chronic drug‐induced liver injury: A prospective randomized clinical trial (2024)
Journal Article
Huang, A., Zhu, Y., Liu, S., Sun, Y., Liu, Z., Liang, Q., Zhao, J., Chang, B., Bi, J., Liu, J., Zhai, X., Xie, H., Li, N., Tian, H., Han, L., Zhuang, Y., Ma, H., Teng, G., Zhang, W., …Zou, Z. (2024). An optimized short‐term steroid therapy for chronic drug‐induced liver injury: A prospective randomized clinical trial. Liver International, 44(6), 1435-1447. https://doi.org/10.1111/liv.15899

Background and Aims
The use of corticosteroids in chronic drug-induced liver injury (DILI) is an important issue. Our previous randomized controlled trial showed that patients with chronic DILI benefited from a 48-week steroid stepwise reduction (SS... Read More about An optimized short‐term steroid therapy for chronic drug‐induced liver injury: A prospective randomized clinical trial.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2024)
Journal Article
Abhishek, A., Grainge, M., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Stevenson, M. D., Nakafero, G., & Riley, R. (2024). Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation. RMD Open, 10(1), e003980. https://doi.org/10.1136/rmdopen-2023-003980

Background Sulfasalazine-induced cytopenia, nephrotoxicity and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend 3 monthly monitoring blood tests indefinitely during long-term treatment while others recommend stopping m... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Translating the potential of the urine steroid metabolome to stage NAFLD (TrUSt-NAFLD): study protocol for a multicentre, prospective validation study. (2024)
Journal Article
Miller, H., Harman, D., Aithal, G. P., Manousou, P., Cobbold, J. F., Parker, R., Sheridan, D., Newsome, P. N., Karpe, F., Neville, M., Arlt, W., Sitch, A. J., Korbonits, M., Biehl, M., Alazawi, W., & Tomlinson, J. W. (2024). Translating the potential of the urine steroid metabolome to stage NAFLD (TrUSt-NAFLD): study protocol for a multicentre, prospective validation study. BMJ Open, 14(1), e074918. https://doi.org/10.1136/bmjopen-2023-074918

Introduction

Non- alcoholic fatty liver disease (NAFLD) affects approximately one in four individuals and its prevalence continues to rise. The advanced stages of NAFLD with significant liver fibrosis are associated with adverse morbidity and mor... Read More about Translating the potential of the urine steroid metabolome to stage NAFLD (TrUSt-NAFLD): study protocol for a multicentre, prospective validation study..

The Hepatokine Leukocyte Cell-Derived Chemotaxin-2 Is Elevated in People with Impaired Glycaemic Regulation and Augmented by Acute Exercise (2024)
Journal Article
Engin, B., Willis, S. A., Malaikah, S., Sargeant, J. A., Stensel, D. J., Jelleyman, C., Ennequin, G., Aithal, G. P., Yates, T., & King, J. A. (2024). The Hepatokine Leukocyte Cell-Derived Chemotaxin-2 Is Elevated in People with Impaired Glycaemic Regulation and Augmented by Acute Exercise. Livers, 4(1), 51-62. https://doi.org/10.3390/livers4010005

The hepatokine leukocyte cell-derived chemotaxin-2 (LECT2) promotes insulin resistance and hepatic fibrogenesis. In rodents, acute exercise suppresses circulating LECT2; however, human data are lacking. This study compared circulating LECT2 across po... Read More about The Hepatokine Leukocyte Cell-Derived Chemotaxin-2 Is Elevated in People with Impaired Glycaemic Regulation and Augmented by Acute Exercise.