Both reversible self-association and structural changes underpin molecular viscoelasticity of mAb solutions

Sarangapani, Prasad S.; Weaver, Justin; Parupudi, Arun; Besong, Tabot M.D.; Adams, Gary G.; Harding, Stephen E.; Manikwar, Prakash; Castellanos, Maria M.; Bishop, Steven M.; Pathak, Jai A.

doi:10.1016/j.xphs.2016.08.020

Obesity in Nigerian Adults and the Associated Cause and Impact on the Population (2022)
Journal Article
Ellecom, J. B., Shaw, I., & Adams, G. G. (2022). Obesity in Nigerian Adults and the Associated Cause and Impact on the Population. Journal of Diabetes Research Reviews & Reports, 4(4), 1-11. https://doi.org/10.47363/JDRR/2022%284%29165

Background: Obesity has been on the rise in developed and developing countries such as Nigeria. Data from the WHO demonstrated the prevalence of obesity increased by 15% between 2002 and 2016 in Nigeria. Here, we examine the rate of obesity in Nigeri... Read More about Obesity in Nigerian Adults and the Associated Cause and Impact on the Population.

Physical activity pre-and during pregnancy and gestational diabetes onset across multi-ethnic pregnant populations: a systematic review and meta-analysis of epidemiological studies (2022)
Journal Article
Alaslani, H., Shaw, I., & Adams, G. (2023). Physical activity pre-and during pregnancy and gestational diabetes onset across multi-ethnic pregnant populations: a systematic review and meta-analysis of epidemiological studies. MOJ Public Health, 11(1), 28-32. https://doi.org/10.15406/mojph.2022.11.00370

Background: Gestational diabetes mellitus (GDM) is a common complication during pregnancy and is associated with adverse pregnancy outcomes and maternal and neonatal risks. Lifestyle intervention through physical activity is generally similar to diet... Read More about Physical activity pre-and during pregnancy and gestational diabetes onset across multi-ethnic pregnant populations: a systematic review and meta-analysis of epidemiological studies.

Motor Developmental Outcomes in Children Exposed to Maternal Diabetes During Pregnancy: A Systematic Review and Meta-Analysis (2021)
Journal Article
Arabiat, D., Jabery, M. A., Kemp, V., Jenkins, M., Whitehead, L. C., & Adams, G. (2021). Motor Developmental Outcomes in Children Exposed to Maternal Diabetes During Pregnancy: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 18(4), Article 1699. https://doi.org/10.3390/ijerph18041699

Studies on the association of maternal diabetes with motor development in children provide inconsistent findings. We searched MEDLINE/PubMed, EMBASE, Emcare, PsycINFO, and Google Scholar databases for primary observational, case–control, or cohort st... Read More about Motor Developmental Outcomes in Children Exposed to Maternal Diabetes During Pregnancy: A Systematic Review and Meta-Analysis.

Probing the effect of aroma compounds on the hydrodynamic properties of mucin glycoproteins (2020)
Journal Article
Dinu, V., MacCalman, T., Yang, N., Adams, G. G., Yakubov, G. E., Harding, S. E., & Fisk, I. D. (2020). Probing the effect of aroma compounds on the hydrodynamic properties of mucin glycoproteins. European Biophysics Journal, 49(8), 799-808. https://doi.org/10.1007/s00249-020-01475-4

© 2020, The Author(s). Aroma compounds are diverse low molecular weight organic molecules responsible for the flavour of food, medicines or cosmetics. Natural and artificial aroma compounds are manufactured and used by the industry to enhance the fla... Read More about Probing the effect of aroma compounds on the hydrodynamic properties of mucin glycoproteins.

Food biotechnology (2020)
Journal Article
Foster, T., Adams, G., di Bari, V., Connerton, I., Gould, J., Gouseti, O., …Yakubov, G. (2020). Food biotechnology. Current Opinion in Chemical Engineering, 30, 53-59. https://doi.org/10.1016/j.coche.2020.08.006

We investigate recent advances in the Chemical Engineering aspects of food structuring agents and macronutrients: carbohydrates, proteins and lipids, and also the fate of food upon ingestion. Prebiotic effects on host-microbe interactions enable impr... Read More about Food biotechnology.

Effectiveness of Community Health Worker-led Diabetes Self-Management Education on Type 2 diabetes patients: A Systematic Review and Meta-Analysis (2020)
Journal Article
Amagyei, A., Meal, A., Shaw, I., & Adams, G. G. (2020). Effectiveness of Community Health Worker-led Diabetes Self-Management Education on Type 2 diabetes patients: A Systematic Review and Meta-Analysis. International Journal of Diabetes, 1(2), 40-50

Objective: Community Health Workers are important in building individual and community capacity through outreach, community education, informal counselling, social support and advocacy programs, which enhance health knowledge and self-sufficiency. Ou... Read More about Effectiveness of Community Health Worker-led Diabetes Self-Management Education on Type 2 diabetes patients: A Systematic Review and Meta-Analysis.

Is Liraglutide a Safe and Effective Medication to Treat Hyperglycaemia?: A Systematic Review (2020)
Journal Article
Al Oneze, A., Jiwan, S. I., Gyasi-Antw, P., Meal, A., & Adams, G. G. (2020). Is Liraglutide a Safe and Effective Medication to Treat Hyperglycaemia?: A Systematic Review. Annals of Clinical Diabetes and Endocrinology, 3(2), Article 1017

Background: The aim of this systematic review is to examine the effectiveness of Liraglutide on glycemic control and Systolic Blood Pressure (SBP) in patients with Type 2 Diabetes (T2D) mellitus and to investigate whether Liraglutide leads to any Gas... Read More about Is Liraglutide a Safe and Effective Medication to Treat Hyperglycaemia?: A Systematic Review.

Effect of Lifestyle and Diet on Gestational Diabetes (GDM) in South Asian Women: A Systematic Review (2020)
Journal Article
Naseer, N., Shaw, I., & Adams, G. (2020). Effect of Lifestyle and Diet on Gestational Diabetes (GDM) in South Asian Women: A Systematic Review. Journal of Diabetes & Metabolic Syndrome, 3(1), Article 100010

Background: Evidence suggests that all forms of diabetes are on the increase, especially Gestational Diabetes Mellitus (GDM), which increases the risk of maternal and neonatal morbidities. However, the global effect of diet (HA) and lifestyle (PA) of... Read More about Effect of Lifestyle and Diet on Gestational Diabetes (GDM) in South Asian Women: A Systematic Review.

Characterisation of the molecular properties of scleroglucan as an alternative rigid rod molecule to xanthan gum for oropharyngeal dysphagia (2019)
Journal Article
Li, X., Lu, Y., Adams, G. G., Zobel, H., Ballance, S., Wolf, B., & Harding, S. E. (2020). Characterisation of the molecular properties of scleroglucan as an alternative rigid rod molecule to xanthan gum for oropharyngeal dysphagia. Food Hydrocolloids, 101, 1-9. https://doi.org/10.1016/j.foodhyd.2019.105446

Scleroglucan, a neutral β(1–3) glucan with β(1–6) glucan branches every third residue, is being considered as an alternative rod-like, shear thinning high molecular weight β-glucan based polysaccharide to xanthan gum for the management of patients wi... Read More about Characterisation of the molecular properties of scleroglucan as an alternative rigid rod molecule to xanthan gum for oropharyngeal dysphagia.

Relationship between Lipohypertrophy, Injection Techniques and Education in adults with Type 2 Diabetes: A Systematic Review (2019)
Journal Article
Thomas, J., Meal, A., & Adams, G. G. (2019). Relationship between Lipohypertrophy, Injection Techniques and Education in adults with Type 2 Diabetes: A Systematic Review. Journal of Diabetes and Treatment, 4(2), Article 1074. https://doi.org/10.29011/2574-7568.001074

Introduction: This systematic review examines Lipohypertrophy (LH) in patients presenting with Type 1/2 Diabetes (T1/2DM) in relation to education and injection techniques. LH is a condition, which occurs in diabetes individuals at injection sights.... Read More about Relationship between Lipohypertrophy, Injection Techniques and Education in adults with Type 2 Diabetes: A Systematic Review.

Mucin immobilization in calcium alginate: A possible mucus mimetic tool for evaluating mucoadhesion and retention of flavour (2019)
Journal Article
Dinu, V., Yakubov, G. E., Lim, M., Hurst, K., Adams, G. G., Harding, S. E., & Fisk, I. D. (2019). Mucin immobilization in calcium alginate: A possible mucus mimetic tool for evaluating mucoadhesion and retention of flavour. International Journal of Biological Macromolecules, 138, 831-836. https://doi.org/10.1016/j.ijbiomac.2019.07.148

To reduce animal testing, there is a need to develop novel in-vitro models for evaluating the retention of bioactive compounds in food and pharmaceutical products. Here, a mucus-mimetic platform was developed through a one-step approach based on enca... Read More about Mucin immobilization in calcium alginate: A possible mucus mimetic tool for evaluating mucoadhesion and retention of flavour.

Submaxillary Mucin: its Effect on Aroma Release from Acidic Drinks and New Insight into the Effect of Aroma Compounds on its Macromolecular Integrity (2019)
Journal Article
Dinu, V., Gillis, R. B., MacCalman, T., Lim, M., Adams, G. G., Harding, S. E., & Fisk, I. D. (2019). Submaxillary Mucin: its Effect on Aroma Release from Acidic Drinks and New Insight into the Effect of Aroma Compounds on its Macromolecular Integrity. Food Biophysics, 14(3), 278-286. https://doi.org/10.1007/s11483-019-09574-2

Submaxillary mucin is a major component that defines the makeup and functionality of saliva. Understanding its structure and function during food intake is key to designing appropriate strategies for enhancing the delivery of flavour. In the present... Read More about Submaxillary Mucin: its Effect on Aroma Release from Acidic Drinks and New Insight into the Effect of Aroma Compounds on its Macromolecular Integrity.

The practice of glycaemic control in intensive care units: A multicentre survey of nursing and medical professionals (2019)
Journal Article
Fernández‐Méndez, R., Harvey, D. J. R., Windle, R., & Adams, G. G. (2019). The practice of glycaemic control in intensive care units: A multicentre survey of nursing and medical professionals. Journal of Clinical Nursing, 28(11-12), 2088-2100. https://doi.org/10.1111/jocn.14774

Aims and objectives To determine the views of nurses and physicians working in intensive care units (ICU) about the aims of glycaemic control and use of their protocols. Background Evidence about the optimal aims and methods for glycaemic contro... Read More about The practice of glycaemic control in intensive care units: A multicentre survey of nursing and medical professionals.

Outcomes of mindfulness-based stress reduction and mindfulness-based cognitive therapy in adults with diabetes: a systematic review (2018)
Journal Article
Mason, J., Meal, A., Shaw, I., & Adams, G. G. (in press). Outcomes of mindfulness-based stress reduction and mindfulness-based cognitive therapy in adults with diabetes: a systematic review. Journal of Diabetes and Treatment, 2018(2), https://doi.org/10.29011/2574-7568.000049

Objectives: Diabetes Mellitus (DM) is a global and progressive chronic medical condition with increasing prevalence and associated costs throughout the world. Psychological problems are common in people with DM and when they co-occur are associated w... Read More about Outcomes of mindfulness-based stress reduction and mindfulness-based cognitive therapy in adults with diabetes: a systematic review.

Characterisation of insulin analogues therapeutically available to patients (2018)
Journal Article
Adams, G. G., Meal, A., Morgan, P. S., Alzahrani, Q. E., Zobel, H., Lithgo, R., …Chayen, N. (2018). Characterisation of insulin analogues therapeutically available to patients. PLoS ONE, 13(3), Article e0195010. https://doi.org/10.1371/journal.pone.0195010

The structure and function of clinical dosage insulin and its analogues were assessed. This included ‘native insulins’ (human recombinant, bovine, porcine), ‘fast-acting analogues’ (aspart, glulisine, lispro) and ‘slow-acting analogues’ (glargine, de... Read More about Characterisation of insulin analogues therapeutically available to patients.

Glargine and degludec: solution behaviour of higher dose synthetic insulins (2017)
Journal Article
Adams, G. G., Alzahrani, Q., Jiwani, S. I., Meal, A., Morgan, P. S., Coffey, F., …Gillis, R. B. (2017). Glargine and degludec: solution behaviour of higher dose synthetic insulins. Scientific Reports, 7(1), Article 7287. https://doi.org/10.1038/s41598-017-06642-w

Single, double and triple doses of the synthetic insulins glargine and degludec currently used in patient therapy are characterised using macromolecular hydrodynamic techniques (dynamic light scattering and analytical ultracentrifugation) in an attem... Read More about Glargine and degludec: solution behaviour of higher dose synthetic insulins.

Health beliefs predict self-care practices and glycaemic control in Malaysian patients with insulin-treated diabetes: a longtitudal study (2017)
Journal Article
Aris, A., Blake, H., & Adams, G. (2017). Health beliefs predict self-care practices and glycaemic control in Malaysian patients with insulin-treated diabetes: a longtitudal study. Malaysian Journal of Public Health Medicine, 17(2), 80-89

The practice of diabetes self-care plays an important role in achieving and maintaining good glycaemic control. However, not all patients with insulin-treated diabetes engage in their self-care activities. There is some evidence that self-care practi... Read More about Health beliefs predict self-care practices and glycaemic control in Malaysian patients with insulin-treated diabetes: a longtitudal study.

Dietitians' practice in giving carbohydrate advice in the management of type 2 diabetes: a mixed methods study (2016)
Journal Article
McArdle, P. D., Greenfield, S. M., Avery, A., Adams, G. G., & Gill, P. S. (in press). Dietitians' practice in giving carbohydrate advice in the management of type 2 diabetes: a mixed methods study. Journal of Human Nutrition and Dietetics, 30(3), https://doi.org/10.1111/jhn.12436

Background: Carbohydrate is accepted as the principal nutrient affecting blood glucose in diabetes; however, current guidelines are unable to specify the optimal quantity of carbohydrate for glycaemic control. No studies exist that describe current p... Read More about Dietitians' practice in giving carbohydrate advice in the management of type 2 diabetes: a mixed methods study.

Solution conformation and flexibility of capsular polysaccharides from Neisseria meningitidis and glycoconjugates with the tetanus toxoid protein (2016)
Journal Article
Abdelhameed, A. S., Morris, G. A., Almutairi, F., Adams, G. G., Duvivier, P., Conrath, K., & Harding, S. E. (in press). Solution conformation and flexibility of capsular polysaccharides from Neisseria meningitidis and glycoconjugates with the tetanus toxoid protein. Scientific Reports, 6(1), 1-11. https://doi.org/10.1038/srep35588

The structural integrity of meningococcal native, micro-fluidized and activated capsular polysaccharides and their glycoconjugates – in the form most relevant to their potential use as vaccines (dilute solution) - have been investigated with respect... Read More about Solution conformation and flexibility of capsular polysaccharides from Neisseria meningitidis and glycoconjugates with the tetanus toxoid protein.

Both reversible self-association and structural changes underpin molecular viscoelasticity of mAb solutions (2016)
Journal Article
Sarangapani, P. S., Weaver, J., Parupudi, A., Besong, T. M., Adams, G. G., Harding, S. E., …Pathak, J. A. (2016). Both reversible self-association and structural changes underpin molecular viscoelasticity of mAb solutions. Journal of Pharmaceutical Sciences, 105(12), https://doi.org/10.1016/j.xphs.2016.08.020

The role of antibody structure (conformation) in solution rheology is probed. It is demonstrated here that pH-dependent changes in the tertiary structure of 2 mAb solutions lead to viscoelasticity and not merely a shear viscosity (η) increase. Steady... Read More about Both reversible self-association and structural changes underpin molecular viscoelasticity of mAb solutions.

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