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Motor Developmental Outcomes in Children Exposed to Maternal Diabetes During Pregnancy: A Systematic Review and Meta-Analysis

Arabiat, Diana; Jabery, Mohammad AL; Kemp, Vivien; Jenkins, Mark; Whitehead, Lisa C.; Adams, Gary

Motor Developmental Outcomes in Children Exposed to Maternal Diabetes During Pregnancy: A Systematic Review and Meta-Analysis Thumbnail


Authors

Diana Arabiat

Mohammad AL Jabery

Vivien Kemp

Mark Jenkins

Lisa C. Whitehead



Abstract

Studies on the association of maternal diabetes with motor development in children provide inconsistent findings. We searched MEDLINE/PubMed, EMBASE, Emcare, PsycINFO, and Google Scholar databases for primary observational, case–control, or cohort studies that report on the motor development of children exposed to maternal diabetes during pregnancy. Quality appraisal and data extraction were performed independently and in duplicate. A meta-analysis of summary measures was performed using random-effect models. Eighteen studies were identified for inclusion, however, only 13 were included in the meta-analysis. Exposure to maternal diabetes during pregnancy was associated with a lower pooled motor development in children and a decrease in both gross and fine motor development. Among all other factors, pre-existing diabetes and other gestational comorbidities, such as hypertension and obesity, or low socioeconomic status, also affect child development. Therefore, among children of diabetic mothers, those with other gestational comorbidities or pre-existing diabetes were more likely to be at risk developmentally.

Citation

Arabiat, D., Jabery, M. A., Kemp, V., Jenkins, M., Whitehead, L. C., & Adams, G. (2021). Motor Developmental Outcomes in Children Exposed to Maternal Diabetes During Pregnancy: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 18(4), Article 1699. https://doi.org/10.3390/ijerph18041699

Journal Article Type Article
Acceptance Date Feb 6, 2021
Online Publication Date Feb 10, 2021
Publication Date Feb 10, 2021
Deposit Date Feb 15, 2021
Publicly Available Date Mar 4, 2021
Journal International Journal of Environmental Research and Public Health
Print ISSN 1660-4601
Electronic ISSN 1660-4601
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 18
Issue 4
Article Number 1699
DOI https://doi.org/10.3390/ijerph18041699
Public URL https://nottingham-repository.worktribe.com/output/5320049
Publisher URL https://www.mdpi.com/1660-4601/18/4/1699

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