All Outputs (7)

The mitotic chromosome periphery modulates chromosome mechanics (2025)
Journal Article
Mendonca, T., Urban, R., Lucken, K., Coney, G., M. Kad, N., Tassieri, M., J. Wright, A., & G. Booth, D. (2025). The mitotic chromosome periphery modulates chromosome mechanics. Nature Communications, 16, Article 6399. https://doi.org/10.1038/s41467-025-61755-5

In dividing cells, chromosomes are coated in a sheath of proteins and RNA called the mitotic chromosome periphery. This sheath is thought to confer biophysical properties to chromosomes, critical for successful cell division. However, the details of... Read More about The mitotic chromosome periphery modulates chromosome mechanics.

The Mitotic Chromosome Periphery: A Fluid Coat That Mediates Chromosome Mechanics (2024)
Preprint / Working Paper
Mendonca, T., Urban, R., Lucken, K., Coney, G., Tassieri, M., Kad, N. M., Wright, A. J., & Booth, D. G. (2024). The Mitotic Chromosome Periphery: A Fluid Coat That Mediates Chromosome Mechanics

Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis (2018)
Journal Article
Samejima, K., Booth, D. G., Ogawa, H., Paulson, J. R., Xie, L., Watson, C. A., Platani, M., Kanemaki, M. T., & Earnshaw, W. C. (2018). Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis. Journal of Cell Science, 131(4), Article jcs210187. https://doi.org/10.1242/jcs.210187

Stepwise unfolding supports a subunit model for vertebrate kinetochores (2017)
Journal Article
Vargiu, G., Makarov, A. A., Allan, J., Fukagawa, T., Booth, D. G., & Earnshaw, W. C. (2017). Stepwise unfolding supports a subunit model for vertebrate kinetochores. Proceedings of the National Academy of Sciences, 114(12), 3133-3138. https://doi.org/10.1073/pnas.1614145114

3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin (2016)
Journal Article
Booth, D. G., Beckett, A. J., Molina, O., Samejima, I., Masumoto, H., Kouprina, N., Larionov, V., Prior, I. A., & Earnshaw, W. C. (2016). 3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin. Molecular Cell, 64(4), 790-802. https://doi.org/10.1016/j.molcel.2016.10.009

Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis (2016)
Journal Article
Robson, M., de las Heras, J., Czapiewski, R., Lê Thành, P., Booth, D., Kelly, D., Webb, S., Kerr, A., & Schirmer, E. (2016). Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis. Molecular Cell, 62(6), 834-847. https://doi.org/10.1016/j.molcel.2016.04.035

Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery (2014)
Journal Article
Booth, D. G., Takagi, M., Sanchez-Pulido, L., Petfalski, E., Vargiu, G., Samejima, K., Imamoto, N., Ponting, C. P., Tollervey, D., Earnshaw, W. C., & Vagnarelli, P. (2014). Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery. eLife, 3, Article e01641. https://doi.org/10.7554/elife.01641

When the nucleolus disassembles during open mitosis, many nucleolar proteins and RNAs associate with chromosomes, establishing a perichromosomal compartment coating the chromosome periphery. At present nothing is known about the function of this poor... Read More about Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery.