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Exemplification of catalyst design for microwave selective heating and its application to efficient in situ catalyst synthesis (2017)
Journal Article
Wang, K., Dimitrakis, G., & Irvine, D. J. (2017). Exemplification of catalyst design for microwave selective heating and its application to efficient in situ catalyst synthesis. Chemical Engineering and Processing: Process Intensification, 122, https://doi.org/10.1016/j.cep.2017.01.012

The use of dielectric spectroscopy to develop an underpinning understanding of the molecular transformations involved in achieving the successful, rapid in situ synthesis of a catalytic chain transfer polymerisation (CCTP) catalyst using microwave he... Read More about Exemplification of catalyst design for microwave selective heating and its application to efficient in situ catalyst synthesis.

Utilization of dielectric properties assessment to evaluate the catalytic activity and rate of deactivation of heterogeneous catalysts (2017)
Journal Article
Sibianu, T. I., Dimitrakis, G., Katrib, J., Matei, C., Berger, D., Dodds, C., Surdu, A. V., Calinescu, I., & Irvine, . D. J. (2017). Utilization of dielectric properties assessment to evaluate the catalytic activity and rate of deactivation of heterogeneous catalysts. 00 Journal not listed, 56(8), 1940–1947. https://doi.org/10.1021/acs.iecr.6b04341

Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release (2016)
Journal Article
Kakde, D., Taresco, V., Bansal, K. K., Magennis, E. P., Howdle, S. M., Mantovani, G., Irvine, D. J., & Alexander, C. (in press). Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release. Journal of Materials Chemistry B, 44, https://doi.org/10.1039/C6TB01839D

Here we describe a methoxy poly(ethyleneglycol)-b-poly(ε-decalactone) (mPEG-b-PεDL) copolymer and investigate the potential of the copolymer as a vehicle for solubilisation and sustained release of indomethacin (IND). The indomethacin loading and rel... Read More about Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release.

Additive manufacture of three dimensional nanocomposite based objects through multiphoton fabrication (2016)
Journal Article
Liu, Y., Hu, Q., Zhang, F., Tuck, C., Irvine, D., Hague, R. J., Yinfeng, H., Simonelli, M., Rance, G., Smith, E., & Wildman, R. D. (2016). Additive manufacture of three dimensional nanocomposite based objects through multiphoton fabrication. Polymers, 8(9), 1-14. https://doi.org/10.3390/polym8090325

Three dimensional structures prepared from a gold-polymer composite formulation have been fabricated using multiphoton lithography. In this process, gold nanoparticles were simultaneously formed through photoreduction whilst polymerisation of two pos... Read More about Additive manufacture of three dimensional nanocomposite based objects through multiphoton fabrication.

Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers (2016)
Journal Article
Adlington, K., Nguyen, N. T., Eaves, E., Yang, J., Chang, C. Y., Li, J., Gower, A. L., Stimpson, A., Anderson, D. G., Langer, R., Davies, M. C., Hook, A. L., Williams, P., Alexander, M. R., & Irvine, D. J. (2016). Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers. Biomacromolecules, 17(9), 2830-2838. https://doi.org/10.1021/acs.biomac.6b00615

© 2016 American Chemical Society. Developing medical devices that resist bacterial attachment and subsequent biofilm formation is highly desirable. In this paper, we report the optimization of the molecular structure and thus material properties of a... Read More about Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers.

Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers (2016)
Journal Article
Kakde, D., Powell, L. G., Bansal, K. K., Howdle, S., Irvine, D., Mantovani, G., Millar, G., Dailey, L. A., Stone, V., Johnston, H. J., & Alexander, C. (2016). Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers. Journal of Controlled Release, 244(B), https://doi.org/10.1016/j.jconrel.2016.08.003

Polyesters are extensively used in drug delivery because of their controllable biodegradation properties and perceived favorable cytocompatibility. However, new ester-based materials are continually being sought which can be produced from readily acc... Read More about Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers.

Facile Determination of Molecular Structure Trends in Amphiphilic Core Corona Star Polymer Synthesis via Dielectric Property Measurement (2016)
Journal Article
Katrib, J., Irvine, D., Hild, F., Nguyen, N., Deng, E., Dimitrakis, G., & Lau, P.-L. (2016). Facile Determination of Molecular Structure Trends in Amphiphilic Core Corona Star Polymer Synthesis via Dielectric Property Measurement. Macromolecular Rapid Communications, 37(15), 1295-1299. https://doi.org/10.1002/marc.201600149

The use of dielectric property measurements to define specific trends in the molecular structures of poly(caprolactone) containing star polymers and/or the interbatch repeatability of the synthetic procedures used to generate them is demonstrated. Th... Read More about Facile Determination of Molecular Structure Trends in Amphiphilic Core Corona Star Polymer Synthesis via Dielectric Property Measurement.

A facile and green route to terpene derived acrylate and methacrylate monomers and simple free radical polymerisation to yield new renewable polymers and coatings (2016)
Journal Article
Sainz, M. F., Souto, J. A., Regentova, D., Johansson, M. K. G., Timhagen, S. T., Irvine, D. J., Buijsen, P., Koning, C. E., Stockman, R. A., & Howdle, S. M. (2016). A facile and green route to terpene derived acrylate and methacrylate monomers and simple free radical polymerisation to yield new renewable polymers and coatings. Polymer Chemistry, 7(16), 2882-2887. https://doi.org/10.1039/c6py00357e

We present new acrylic monomers derived directly from abundant naturally available terpenes via a facile, green and catalytic approach. These monomers can be polymerised to create new polymers with a wide range of mechanical properties that positions... Read More about A facile and green route to terpene derived acrylate and methacrylate monomers and simple free radical polymerisation to yield new renewable polymers and coatings.

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: in vitro degradation and mechanical properties (2015)
Journal Article
Chen, M., Parsons, A. J., Felfel, R. M., Rudd, C. D., Irvine, D. J., & Ahmed, I. (2016). In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: in vitro degradation and mechanical properties. Journal of the Mechanical Behavior of Biomedical Materials, 59, 78-89. https://doi.org/10.1016/j.jmbbm.2015.12.019

Fully bioresorbable composites have been investigated in order to replace metal implant plates used for hard tissue repair. Retention of the composite mechanical properties within a physiological environment has been shown to be significantly affecte... Read More about In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: in vitro degradation and mechanical properties.

Molecular Design of Squalene/Squalane Countertypes via the Controlled Oligomerization of Isoprene and Evaluation of Vaccine Adjuvant Applications (2015)
Journal Article
Adlington, K., El harfi, J., Li, J., Carmichael, K., Guderian, J. A., Fox, C. B., & Irvine, D. (2015). Molecular Design of Squalene/Squalane Countertypes via the Controlled Oligomerization of Isoprene and Evaluation of Vaccine Adjuvant Applications. Biomacromolecules, 17(1), 165-172. https://doi.org/10.1021/acs.biomac.5b01285

The potential to replace shark-derived squalene in vaccine adjuvant applications with synthetic squalene/poly(isoprene) oligomers, synthesized by the controlled oligomerization of isoprene is demonstrated. Following on from our previous work regardin... Read More about Molecular Design of Squalene/Squalane Countertypes via the Controlled Oligomerization of Isoprene and Evaluation of Vaccine Adjuvant Applications.

Molecular differentiated initiator reactivity in the synthesis of poly(caprolactone)-based hydrophobic homopolymer and amphiphilic core corona star polymers (2015)
Journal Article
Deng, E., Nguyen, N. T., Hild, F., Hamilton, I. E., Dimitrakis, G., Kingman, S. W., Lau, P.-L., & Irvine, D. J. (2015). Molecular differentiated initiator reactivity in the synthesis of poly(caprolactone)-based hydrophobic homopolymer and amphiphilic core corona star polymers. Molecules, 20(11), 20131-20145. https://doi.org/10.3390/molecules201119681

Macromolecules that possess three-dimensional, branched molecular structures are of great interest because they exhibit significantly differentiated application performance compared to conventional linear (straight chain) polymers. This paper reports... Read More about Molecular differentiated initiator reactivity in the synthesis of poly(caprolactone)-based hydrophobic homopolymer and amphiphilic core corona star polymers.

Continuous synthesis of dispersant-coated hydroxyapatite plates (2015)
Journal Article
Gimeno-Fabra, M., Hild, F., Dunne, P., Walton, K., Grant, D., Irvine, D. J., & Lester, E. (2015). Continuous synthesis of dispersant-coated hydroxyapatite plates. CrystEngComm, 17(32), 6175-6182. https://doi.org/10.1039/c5ce00628g

A continuous flow hydrothermal synthetic route which allows the direct “in situ” capping/coating of hydroxyapatite nanoplates with functional dispersants in a single stage is reported. The methodology induced crystallisation by rapid mixing of stream... Read More about Continuous synthesis of dispersant-coated hydroxyapatite plates.

Enhanced ‘in situ’ catalysis via microwave selective heating: catalytic chain transfer polymerisation (2014)
Journal Article
Adlington, K., McSweeney, R., Dimitrakis, G., Kingman, S. W., Robinson, J. P., & Irvine, D. J. (2014). Enhanced ‘in situ’ catalysis via microwave selective heating: catalytic chain transfer polymerisation. RSC Advances, 4(31), 16172-16180. https://doi.org/10.1039/c4ra00907j

An extremely facile, single stage, ‘in-situ’, Catalytic Chain Transfer Polymerisation (CCTP) process has been identified, where the optimal polymerisation process was shown to depend upon a combination of catalyst characteristics (i.e. solubility, se... Read More about Enhanced ‘in situ’ catalysis via microwave selective heating: catalytic chain transfer polymerisation.

Continuous and direct 'in situ' reaction monitoring of chemical reactions via dielectric property measurement: Controlled polymerisation (2014)
Journal Article
Lester, E., Kamaruddin, M. J., Nguyen, N. T., Robinson, J., El harfi, J., Irvine, D., Binner, E. R., DIMITRAKIS, G., & Kingman, S. W. (2014). Continuous and direct 'in situ' reaction monitoring of chemical reactions via dielectric property measurement: Controlled polymerisation. RSC Advances, 4(11), 5709-5717. https://doi.org/10.1039/c3ra46941g

On DABAL-Me₃ promoted formation of amides (2013)
Journal Article
Dubois, N., Glynn, D., Mcinally, T., Rhodes, B., Woodward, S., Irvine, D., & Dodds, C. (2013). On DABAL-Me₃ promoted formation of amides. Tetrahedron, 69(46), https://doi.org/10.1016/j.tet.2013.08.062

The range and utility of DABAL-Me3 couplings of methyl esters and free carboxylic acids with primary and secondary amines under a variety of conditions (reflux, sealed tube, microwave) has been compared for a significant range of coupling partners of... Read More about On DABAL-Me₃ promoted formation of amides.