Skip to main content

Research Repository

Advanced Search

All Outputs (115)

How people with knee pain understand why their pain changes or remains the same over time: A qualitative study (2023)
Journal Article
Walsh, D. A., Rathbone, J., Akin-Akinyosoye, K., Fernandes, G. S., Valdes, A. M., McWilliams, D. F., Zhang, W., Doherty, M., Hancox, J. E., Vedhara, K., das Nair, R., & Ferguson, E. (2023). How people with knee pain understand why their pain changes or remains the same over time: A qualitative study. Osteoarthritis and Cartilage Open, 5(2), Article 100345. https://doi.org/10.1016/j.ocarto.2023.100345

Objectives
Guidelines recommend knee osteoarthritis pain management based on biopsychosocial mechanisms. Treatment adherence and effectiveness may be affected if there is a mismatch between patient perspectives and treatment focus. We therefore exam... Read More about How people with knee pain understand why their pain changes or remains the same over time: A qualitative study.

Chronic pain in people living with dementia: challenges to recognising and managing pain, and personalising intervention by phenotype (2023)
Journal Article
Collins, J. T., Harwood, R. H., Cowley, A., Di Lorito, C., Ferguson, E., Minicucci, M. F., Howe, L., Masud, T., Ogliari, G., O'Brien, R., Azevedo, P. S., Walsh, D. A., & Gladman, J. R. (2023). Chronic pain in people living with dementia: challenges to recognising and managing pain, and personalising intervention by phenotype. Age and Ageing, 52(1), Article afac306. https://doi.org/10.1093/ageing/afac306

Pain is common in people with dementia, and pain can exacerbate the behavioural and psychological symptoms of dementia. Effective pain management is challenging, not least in people with dementia. Impairments of cognition, communication and abstract... Read More about Chronic pain in people living with dementia: challenges to recognising and managing pain, and personalising intervention by phenotype.

Influence of Social Support, Financial Status, and Lifestyle on the Disparity Between Inflammation and Disability in Rheumatoid Arthritis (2022)
Journal Article
Gwinnutt, J. M., Norton, S., Hyrich, K. L., Lunt, M., Combe, B., Rincheval, N., Ruyssen‐Witrand, A., Fautrel, B., McWilliams, D. F., Walsh, D. A., Nikiphorou, E., Kiely, P. D., Young, A., Chipping, J. R., MacGregor, A., & Verstappen, S. M. (2023). Influence of Social Support, Financial Status, and Lifestyle on the Disparity Between Inflammation and Disability in Rheumatoid Arthritis. Arthritis Care and Research, 75(5), 1026-1035. https://doi.org/10.1002/acr.24996

Objective: To investigate how social support, financial status, and lifestyle influence the development of excess disability in rheumatoid arthritis (RA). Methods: Data were obtained from the Étude et Suivi des Polyarthrites Indifférenciées Récentes... Read More about Influence of Social Support, Financial Status, and Lifestyle on the Disparity Between Inflammation and Disability in Rheumatoid Arthritis.

Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity (2022)
Journal Article
Iwabuchi, S. J., Drabek, M. M., Cottam, W. J., Tadjibaev, A., Mohammadi-Nejad, A. R., Sotiropoulos, S., Fernandes, G. S., Valdes, A. M., Zhang, W., Doherty, M., Walsh, D. A., & Auer, D. P. (2022). Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity. European Journal of Neuroscience, 57(2), 373-387. https://doi.org/10.1111/ejn.15880

The reciprocal interaction between pain and negative affect is acknowledged but pain-related alterations in brain circuits involved in this interaction, such as the mediodorsal thalamus (MDThal), still require a better understanding. We sought to inv... Read More about Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity.

Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD) (2022)
Journal Article
Georgopoulos, V., Smith, S., McWilliams, D. F., Steultjens, M. P. M., Williams, A., Price, A., Valdes, A. M., Vincent, T. L., Watt, F. E., & Walsh, D. A. (2023). Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD). Osteoarthritis and Cartilage, 31(1), 83-95. https://doi.org/10.1016/j.joca.2022.08.011

Objective: In order to facilitate data pooling between studies, we explored harmonisation of patient-reported outcome measures (PROMs) in people with knee pain due to osteoarthritis or knee trauma, using the Patient Acceptable Symptom State scores (P... Read More about Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD).

An observational study of centrally facilitated pain in individuals with chronic low back pain (2022)
Journal Article
Georgopoulos, V., Akin-Akinyosoye, K., Smith, S., McWilliams, D. F., Hendrick, P., & Walsh, D. A. (2022). An observational study of centrally facilitated pain in individuals with chronic low back pain. PAIN Reports, 7(3), Article e1003. https://doi.org/10.1097/PR9.0000000000001003

Central pain facilitation can hinder recovery in people with chronic low back pain (CLBP). The aim of this observational study was to investigate whether indices of centrally facilitated pain are associated with pain outcomes in a hospital-based coho... Read More about An observational study of centrally facilitated pain in individuals with chronic low back pain.

Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain (2022)
Presentation / Conference Contribution
Habib, M., Smith, S., Chaplin, W., Millar, B., McWilliams, D., & Walsh, D. Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain. Presented at Osteoarthritis Research Society International (OARSI), Berlin

Purpose: Pain is the primary clinical manifestation in individuals with osteoarthritis (OA). It is an unpleasant and distressing experience, particularly during weight-bearing activities, inhibiting activity, and reducing quality of life. Two groups... Read More about Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain.

Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis (2022)
Journal Article
Gwinnutt, J. M., Norton, S., Hyrich, K. L., Lunt, M., Combe, B., Rincheval, N., Ruyssen-Witrand, A., Fautrel, B., McWilliams, D. F., Walsh, D. A., Nikiphorou, E., Kiely, P., Young, A., Chipping, J. R., MacGregor, A., & Verstappen, S. M. (2022). Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis. Rheumatology, 61(12), 4687–4701. https://doi.org/10.1093/rheumatology/keac137

OBJECTIVES: To identify groups of people with RA with different disability trajectories over 10 years, despite comparable levels of inflammation. METHODS: Data for this analysis came from three European prospective cohort studies of people with RA [N... Read More about Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis.

Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain (2022)
Journal Article
Gowler, P. R. W., Turnbull, J., Shahtaheri, M., Gohir, S., Kelly, T., McReynolds, C., Yang, J., Jha, R. R., Fernandes, G. S., Zhang, W., Doherty, M., Walsh, D. A., Hammock, B. D., Valdes, A. M., Barrett, D. A., & Chapman, V. (2022). Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain. Arthritis and Rheumatology, 74(4), 623-633. https://doi.org/10.1002/art.42000

Objective: Chronic pain due to osteoarthritis (OA) is a major clinical problem, and existing analgesics often have limited beneficial effects and/or adverse effects, necessitating the development of novel therapies. Epoxyeicosatrienoic acids (EETs) a... Read More about Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain.

Acceptability of a nurse-led non-pharmacological complex intervention for knee pain: Nurse and patient views and experiences (2022)
Journal Article
Nomikos, P. A., Hall, M. C., Fuller, A., Ogollah, R., Valdes, A. M., Doherty, M., Walsh, D. A., das Nair, R., & Abhishek, A. (2022). Acceptability of a nurse-led non-pharmacological complex intervention for knee pain: Nurse and patient views and experiences. PLoS ONE, 17(1), Article e0262422. https://doi.org/10.1371/journal.pone.0262422

Objectives The overall purpose of this research programme is to develop and test the feasibility of a complex intervention for knee pain delivered by a nurse, and comprising both non-pharmacological and pharmacological interventions. In this first ph... Read More about Acceptability of a nurse-led non-pharmacological complex intervention for knee pain: Nurse and patient views and experiences.

Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort (2022)
Journal Article
Swain, S., Fernandes, G. S., Sarmanova, A., Valdes, A. M., Walsh, D. A., Coupland, C., Doherty, M., & Zhang, W. (2022). Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort. Rheumatology Advances in Practice, 6(2), Article rkac049. https://doi.org/10.1093/rap/rkac049

Objectives: The aims were to examine the prevalence of comorbidities and role of oral analgesic use in people with knee pain (KP) compared with those without. Methods: The Knee Pain and related health In the Community (KPIC) cohort comprises communit... Read More about Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort.

Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network (2021)
Journal Article
Ifesemen, O. S., McWilliams, D. F., Norton, S., Kiely, P. D. W., Young, A., & Walsh, D. A. (2022). Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network. Rheumatology, 61(9), 3737-3745. https://doi.org/10.1093/rheumatology/keab947

OBJECTIVES: Fatigue is a disabling symptom in people with RA. This study aims to describe the prevalence, risk factors and longitudinal course of fatigue in early RA. METHODS: Demographic, clinical, quality of life (QoL), comorbidities and laboratory... Read More about Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network.

Different genes may be involved in distal and local sensitization: A genome‐wide gene‐based association study and meta‐analysis (2021)
Journal Article
Kouraki, A., Doherty, M., Fernandes, G. S., Zhang, W., Walsh, D. A., Kelly, A., & Valdes, A. M. (2022). Different genes may be involved in distal and local sensitization: A genome‐wide gene‐based association study and meta‐analysis. European Journal of Pain, 26(3), 740-753. https://doi.org/10.1002/ejp.1902

Background: Neuropathic pain symptoms and signs of increased pain sensitization in osteoarthritis (OA) patients may explain persistent pain after total joint replacement (TJR). Therefore, identifying genetic markers associated with pain sensitization... Read More about Different genes may be involved in distal and local sensitization: A genome‐wide gene‐based association study and meta‐analysis.

Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia (2021)
Journal Article
Lillywhite, A., Woodhams, S. G., Gonçalves, S. V., Watson, D. J. G., Li, L., Burston, J. J., Gowler, P. R. W., Canals, M., Walsh, D. A., Hathway, G. J., & Chapman, V. (2021). Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia. PAIN Reports, 6(4), Article e956. https://doi.org/10.1097/PR9.0000000000000956

Introduction:
Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and future opioid crises.... Read More about Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia.

Identifying multiple knee pain trajectories and the prediction of opioid and NSAID medication used: A latent class growth approach (2021)
Journal Article
Haybatollahi, S. M., James, R. J., Fernandes, G., Valdes, A., Doherty, M., Zhang, W., Walsh, D. A., & Ferguson, E. (2022). Identifying multiple knee pain trajectories and the prediction of opioid and NSAID medication used: A latent class growth approach. Pain Practice, 22(2), 210-221. https://doi.org/10.1111/papr.13082

Background: Knee pain is a major source of distress and disability, with pain progression highly variable between individuals. Previous studies defining pain trajectories have all used a single measure of pain, and these differ across studies. Differ... Read More about Identifying multiple knee pain trajectories and the prediction of opioid and NSAID medication used: A latent class growth approach.

Fidelity assessment of nurse-led non-pharmacological package of care for knee pain in the package development phase of a feasibility randomised controlled trial based in secondary care: A mixed methods study (2021)
Journal Article
Nomikos, P. A., Hall, M., Fuller, A., Millar, B., Ogollah, R., Valdes, A., Doherty, M., Walsh, D. A., Das Nair, R., & Abhishek, A. (2021). Fidelity assessment of nurse-led non-pharmacological package of care for knee pain in the package development phase of a feasibility randomised controlled trial based in secondary care: A mixed methods study. BMJ Open, 11(7), Article e045242. https://doi.org/10.1136/bmjopen-2020-045242

Objectives To evaluate fidelity of delivery of a nurse-led non-pharmacological complex intervention for knee pain. Setting Secondary care. Single-centre study. Study design Mixed methods study. Participants Eighteen adults with chronic knee pain. Inc... Read More about Fidelity assessment of nurse-led non-pharmacological package of care for knee pain in the package development phase of a feasibility randomised controlled trial based in secondary care: A mixed methods study.

The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis (2021)
Journal Article
McWilliams, D. F., Thankaraj, D., Jones-Diette, J., Morgan, R., Ifesemen, O. S., Shenker, N. G., & Walsh, D. A. (2022). The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis. Rheumatology, 61(1), 76-89. https://doi.org/10.1093/rheumatology/keab503

Objectives: Glucocorticosteroids (GCs) are recommended to suppress inflammation in people with active RA. This systematic review and meta-analysis aimed to quantify the effects of systemic GCs on RA pain. Methods: A systematic literature review of ra... Read More about The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis.

Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study (2021)
Journal Article
Ifesemen, O., McWilliams, D. F., Ferguson, E., Wakefield, R., Akin-Akinyosoye, K., Wilson, D., Platts, D., Ledbury, S., & Walsh, D. A. (2021). Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study. BMC Rheumatology, 5(1), Article 23. https://doi.org/10.1186/s41927-021-00187-2

Background: Pain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and fatigue, even when treatment has controlled inflammatory disease. This study aims to validate a self-repor... Read More about Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study.

Using heterogeneity in disease to understand the relationship between health and personality (2021)
Journal Article
James, R., Walsh, D., & Ferguson, E. (2022). Using heterogeneity in disease to understand the relationship between health and personality. Psychology, Health and Medicine, 27(7), 1582-1595. https://doi.org/10.1080/13548506.2021.1903057

The aim of this study was to compare the relationship between two health outcomes (pain and self-reported health) and personality while accounting for heterogeneity in arthritic disease. Traditionally health psychology and other health research has t... Read More about Using heterogeneity in disease to understand the relationship between health and personality.