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3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling (2015)
Journal Article
Taylor, M., Scurr, D., Lutolf, M., Buttery, L. D., Zelzer, M., & Alexander, M. R. (2015). 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling. Biointerphases, 11(2), Article 02A301. https://doi.org/10.1116/1.4928209

Hydrogels have been used extensively in bioengineering as artificial cell culture supports. Investigation of the interrelationship between cellular response to the hydrogel and its chemistry ideally requires methods that allow characterization withou... Read More about 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling.

Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption (2015)
Journal Article
Hook, A. L., Williams, P. M., Alexander, M. R., & Scurr, D. J. (2015). Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption. Biointerphases, 10, Article 019005. https://doi.org/10.1116/1.4906484

The complexity of hyperspectral time of flight secondary ion mass spectrometry (ToF-SIMS) datasets makes their subsequent analysis and interpretation challenging, and is often an impasse to the identification of trends and differences within large sa... Read More about Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption.

3D ToF-SIMS Imaging of Polymer Multilayer Films Using Argon Cluster Sputter Depth Profiling (2015)
Journal Article
Bailey, J., Havelund, R., Shard, A. G., Gilmore, I. S., Alexander, M. R., Sharp, J. S., & Scurr, D. J. (2015). 3D ToF-SIMS Imaging of Polymer Multilayer Films Using Argon Cluster Sputter Depth Profiling. ACS Applied Materials and Interfaces, 7(4), 2654-2659. https://doi.org/10.1021/am507663v

ToF-SIMS imaging with argon cluster sputter depth profiling has provided detailed insight into the three-dimensional (3D) chemical composition of a series of polymer multilayer structures. Depths of more than 15 μm were profiled in these samples whil... Read More about 3D ToF-SIMS Imaging of Polymer Multilayer Films Using Argon Cluster Sputter Depth Profiling.

In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor (2014)
Journal Article
Wuyts, K., Meeus, J., Muees, J., Scurr, D. J., Amssoms, K., Annaert, P., …Van den Mooter, G. (2015). In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor. Journal of Controlled Release, 199, 1-9. https://doi.org/10.1016/j.jconrel.2014.11.020

At present no scientific rationale exists for selecting a particular enabling strategy to formulate a poorly water-soluble drug, although this is crucial as it will influence the in vivo performance of the resulting formulation. This study provides a... Read More about In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor.

Spectroscopic Studies of Internal Injector Deposits (IDID) Resulting from the Use of Non-Commercial Low Molecular Weight Polyisobutylenesuccinimide (PIBSI) (2014)
Journal Article
Barker, J., Reid, J., Snape, C., Scurr, D., & Meredith, W. (2014). Spectroscopic Studies of Internal Injector Deposits (IDID) Resulting from the Use of Non-Commercial Low Molecular Weight Polyisobutylenesuccinimide (PIBSI). SAE International Journal of Fuels and Lubricants, 7(3), 762-770. https://doi.org/10.4271/2014-01-2720

Copyright © 2014 SAE International. Since 2009, there has been a rise in deposits of various types found in diesel fuel injection systems. They have been identified in the filter, the injector tip and recently inside the injector. The latter internal... Read More about Spectroscopic Studies of Internal Injector Deposits (IDID) Resulting from the Use of Non-Commercial Low Molecular Weight Polyisobutylenesuccinimide (PIBSI).

Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment (2014)
Journal Article
Hook, A. L., Chang, C., Scurr, D. J., Langer, R., Anderson, D. G., Williams, P., …Alexander, M. R. (2014). Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment. Advanced Healthcare Materials, 3(7), 1020-1025. https://doi.org/10.1002/adhm.201300518

The thermally triggered release of up to 96% of attached uropathogenic E. coli is achieved on two polymers with opposite changes in surface wettability upon reduction in temperature. This demonstrates that the bacterial attachment to a surface cannot... Read More about Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment.

Strategies for MCR image analysis of large hyperspectral data-sets (2012)
Journal Article
Scurr, D. J., Hook, A. L., Burley, J., Williams, P. M., Anderson, D. G., Langer, R., …Alexander, M. R. (2012). Strategies for MCR image analysis of large hyperspectral data-sets. Surface and Interface Analysis, 45(1), https://doi.org/10.1002/sia.5040

Polymer microarrays are a key enabling technology for high throughput materials discovery. In this study, multivariate image analysis, specifically multivariate curve resolution (MCR), is applied to the hyperspectral time of flight secondary ion mass... Read More about Strategies for MCR image analysis of large hyperspectral data-sets.