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Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis (2025)
Journal Article
Quammie, S., Crooks, C., Aliyu, A., Aithal, G., & Aravinthan, A. D. (2025). Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis. Pancreatology, https://doi.org/10.1016/j.pan.2025.05.003

Introduction: Chronic pancreatitis (CP) is a known risk factor for pancreatic cancer; however its association to extra pancreatic (EP) cancers remains inadequately explored. The aim of this systematic review is to investigate the evidence for CP as a... Read More about Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis.

The Linear Association of Chest Radiograph Opacification With Both Respiratory Physiology and Systemic Inflammation in Hospital In-Patients With Covid-19 Infection (2025)
Journal Article
Crooks, C., Shaw, D., Card, T., Au-Yong, I., Higashi, Y., Giannotti, E., & Fogarty, A. (2025). The Linear Association of Chest Radiograph Opacification With Both Respiratory Physiology and Systemic Inflammation in Hospital In-Patients With Covid-19 Infection. Clinical Respiratory Journal, 19(2), Article e70056. https://doi.org/10.1111/crj.70056

Background: Chest radiographs are generally used for diagnostic purposes. They also have potential to quantify disease severity. This analysis tested the hypothesis that there was an association between chest radiograph opacification and measures of... Read More about The Linear Association of Chest Radiograph Opacification With Both Respiratory Physiology and Systemic Inflammation in Hospital In-Patients With Covid-19 Infection.

Modelling the distribution of the oxygen-haemoglobin dissociation curve in vivo: An observational study (2025)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., Cruickshank, S., Hammond-Pears, S., Shaw, D., Card, T. R., & Fogarty, A. W. (2025). Modelling the distribution of the oxygen-haemoglobin dissociation curve in vivo: An observational study. Respiratory Physiology and Neurobiology, 333, Article 104400. https://doi.org/10.1016/j.resp.2025.104400

Few studies have explored the variability of the oxygen-haemoglobin dissociation curve in vivo.

96,428 blood gas measurements were obtained (80,376 arterial, 6959 venous) from a cohort of 7656 patients who were admitted to a large UK teaching hosp... Read More about Modelling the distribution of the oxygen-haemoglobin dissociation curve in vivo: An observational study.

Chronic pancreatitis: a case ascertainment study (2025)
Journal Article
Quammie, S., Rashid, A., Munya, R., Nicholson, E. S., Clarke, C., Venkatachalapathy, S. V., Crooks, C. J., Aithal, G. P., & Aravinthan, A. D. (2025). Chronic pancreatitis: a case ascertainment study. Frontline Gastroenterology, 16(4), 300-307. https://doi.org/10.1136/flgastro-2024-102786

Background Chronic pancreatitis (CP) is a debilitating condition, characterised by chronic inflammation and fibrosis of the pancreas. The population frequency of CP is poorly understood. Therefore, we used a broad pragmatic approach to estimate the f... Read More about Chronic pancreatitis: a case ascertainment study.

COLOFIT: Development and Internal-External Validation of Models Using Age, Sex, Faecal Immunochemical and Blood Tests to Optimise Diagnosis of Colorectal Cancer in Symptomatic Patients (2025)
Journal Article
Crooks, C. J., West, J., Jones, J., Hamilton, W., Bailey, S. E., Abel, G., Banerjea, A., Rees, C. J., Tamm, A., Nicholson, B. D., Benton, S. C., Hunt, N., COLOFIT, R. G., & Humes, D. J. (2025). COLOFIT: Development and Internal-External Validation of Models Using Age, Sex, Faecal Immunochemical and Blood Tests to Optimise Diagnosis of Colorectal Cancer in Symptomatic Patients. Alimentary Pharmacology and Therapeutics, 61(5), 852-864. https://doi.org/10.1111/apt.18459

Background: Colorectal cancer (CRC) is the third most common cancer in the United Kingdom and the second largest cause of cancer death. Aim: To develop and validate a model using available information at the time of faecal immunochemical testing (FIT... Read More about COLOFIT: Development and Internal-External Validation of Models Using Age, Sex, Faecal Immunochemical and Blood Tests to Optimise Diagnosis of Colorectal Cancer in Symptomatic Patients.

Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers (2024)
Journal Article
Alhasani, A., Modasia, A., Anodiyil, M., Corsetti, M., Aliyu, A., Crooks, C., MARCIANI, L., Reid, J., Yakubov, G., Avery, A., Harris, H., Warren, F., & Spiller, R. (2025). Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers. Journal of Nutrition, 155(3), 839-848. https://doi.org/10.1016/j.tjnut.2024.12.017

Background
Recent studies show that the increase in breath hydrogen (BH2) and symptoms after ingestion of inulin are reduced by coadministering psyllium (PI).

Objectives
To determine if slowing delivery of inulin to the colon by administering it... Read More about Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers.

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation (2024)
Journal Article
Aliyu, A., Dellschaft, N., Hoad, C., Williams, H., Gaudoin, E., Sulaiman, S., Crooks, C., Gowland, P., Alexia, A., Lange, R., Bois de Fer, B., Corsetti, M., Marciani, L., & Spiller, R. (2025). Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation. Clinical Pharmacology and Therapeutics, 177(5), 1284-1291. https://doi.org/10.1002/cpt.3532

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single d... Read More about Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation (2024)
Journal Article
Aliyu, A., Dellschaft, N., Hoad, C., Williams, H., Gaudoin, E., Sulaiman, S., Crooks, C., Gowland, P., Aran, A., Lange, R., Bois De Fer, B., Corsetti, M., Marciani, L., & Spiller, R. (2025). Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation. Clinical Pharmacology and Therapeutics, 117(5), 1284-1291. https://doi.org/10.1002/cpt.3532

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single d... Read More about Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

Improving patient flow - Ethnicity and socioeconomic status are associated with delayed discharge from hospital in patients with Covid-19 infection Background (2024)
Journal Article
Crooks, C., West, J., Gazis, T., Morling, J., Simmonds, M., Juurlink, I., Briggs, S., Cruickshank, S., Hammond-Pears, S., Shaw, D., Card, T., & Fogarty, A. (in press). Improving patient flow - Ethnicity and socioeconomic status are associated with delayed discharge from hospital in patients with Covid-19 infection Background. Journal of Research in Nursing, https://doi.org/10.1177/17449871241310384

One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease (2024)
Journal Article
Costigan, C. M., Warren, F. J., Duncan, A. P., Hoad, C. L., Lewis, N., Hill, T., Crooks, C. J., Morgan, P. S., Ciacci, C., Iovino, P., Sanders, D. S., Hildebrand, F., Gowland, P. A., Spiller, R. C., & Marciani, L. (2024). One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease. Clinical Gastroenterology and Hepatology, https://doi.org/10.1016/j.cgh.2024.11.006

Background & Aims: Currently, the main treatment for celiac disease (CD) is the gluten-free diet (GFD). This observational cohort study investigated the impact of CD and 1 year of GFD on gut function and microbiome. Methods: A total of 36 newly diagn... Read More about One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease.

Adverse health outcomes in offspring of parents with alcohol-related liver disease: Nationwide Danish cohort study (2024)
Journal Article
Jepsen, P., West, J., Larsen, A. K. K., Kann, A. E., Kraglund, F., Morling, J. R., Crooks, C., & Askgaard, G. (2024). Adverse health outcomes in offspring of parents with alcohol-related liver disease: Nationwide Danish cohort study. PLoS Medicine, 21(10), Article e1004483. https://doi.org/10.1371/journal.pmed.1004483

Background AU Parental: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly drinking can cause harm to the offspring. A parent’s: diagnosis of alcohol-related liver disease (ALD) might be an opportunity to reach offspring with preventive interve... Read More about Adverse health outcomes in offspring of parents with alcohol-related liver disease: Nationwide Danish cohort study.

Primary Liver Cancer Risk and Mortality in Patients With Alcohol-Related Cirrhosis in England and Denmark: Observational Cohort Studies (2024)
Journal Article
Jensen, M. D., West, J., Crooks, C., Morling, J. R., Kraglund, F., Card, T., Askgaard, G., & Jepsen, P. (2025). Primary Liver Cancer Risk and Mortality in Patients With Alcohol-Related Cirrhosis in England and Denmark: Observational Cohort Studies. American Journal of Gastroenterology, 120(3), 593-602. https://doi.org/10.14309/ajg.0000000000003077

INTRODUCTION:
Patients with alcohol-related cirrhosis (ALD cirrhosis) have an increased risk of primary liver cancer (hepatocellular carcinoma [HCC] or intrahepatic cholangiocarcinoma [iCCA]). England recommends surveillance for HCC in these patien... Read More about Primary Liver Cancer Risk and Mortality in Patients With Alcohol-Related Cirrhosis in England and Denmark: Observational Cohort Studies.

Systematic review: Mortality associated with raised faecal immunochemical test and positive faecal occult blood results (2024)
Journal Article
Ligori Malcolm, F., Yapa, A. K., Wong, Z. Y., Morton, A. J., Crooks, C., West, J., Banerjea, A., & Humes, D. (2024). Systematic review: Mortality associated with raised faecal immunochemical test and positive faecal occult blood results. Alimentary Pharmacology and Therapeutics, 60(7), 840-854. https://doi.org/10.1111/apt.18208


Background

Faecal haemoglobin (f-Hb) testing is used in colorectal cancer (CRC) screening and increasingly to guide the investigation in patients with symptoms suggestive of CRC. Studies have demonstrated increased mortality with raised f-Hb.... Read More about Systematic review: Mortality associated with raised faecal immunochemical test and positive faecal occult blood results.

Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave (2024)
Journal Article
Acheampong, E., Husain, A. A., Dudani, H., Nayak, A. R., Nag, A., Meena, E., Shrivastava, S. K., McClure, P., Tarr, A. W., Crooks, C., Lade, R., Gomes, R. L., Singer, A., Kumar, S., Bhatnagar, T., Arora, S., Kashyap, R. S., & Monaghan, T. M. (2024). Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave. PLoS ONE, 19(5), Article e0303529. https://doi.org/10.1371/journal.pone.0303529

Wastewater-based epidemiology (WBE) has emerged as an effective environmental surveillance tool for predicting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease outbreaks in high-income countries (HICs) with centralized sewage infr... Read More about Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave.

A requirement for the use of supplementary oxygen to guide medical treatment decisions may introduce bias against non-white individuals (2024)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., Cruickshank, S., Hammond-Pears, S., Shaw, D., Card, T. R., & Fogarty, A. W. (2024). A requirement for the use of supplementary oxygen to guide medical treatment decisions may introduce bias against non-white individuals. European Respiratory Journal, 63(6), Article 2302320. https://doi.org/10.1183/13993003.02320-2023

The effect of diabetes mellitus on perioperative outcomes following colorectal resections: a national cohort study (2024)
Journal Article
Gysling, S., Lewis-Lloyd, C. A., Lobo, D. N., Crooks, C. J., & Humes, D. J. (2024). The effect of diabetes mellitus on perioperative outcomes following colorectal resections: a national cohort study. British Journal of Anaesthesia, 133(1), 67-76. https://doi.org/10.1016/j.bja.2024.04.010

Background: Diabetes mellitus is a significant modulator of postoperative outcomes and is an important risk factor in the patient selection process. We aimed to investigate the effect of diabetes mellitus and use of insulin on outcomes following colo... Read More about The effect of diabetes mellitus on perioperative outcomes following colorectal resections: a national cohort study.

A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study (2024)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C., Marciani, L., Spiller, R., Crooks, C., Hill, T., Menys, A., Mainz, J. G., Barr, H., Gowland, P. A., Major, G., & Smyth, A. R. (2024). A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study. NIHR Open Research, 3, Article 65. https://doi.org/10.3310/nihropenres.13510.2

Background
People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung funct... Read More about A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study.

Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma (2024)
Journal Article
Bishton, M. J., Crooks, C. J., Card, T. R., & West, J. (2024). Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma. British Journal of Haematology, 204(6), 2222-2226. https://doi.org/10.1111/bjh.19371

To address the lack of contemporary population-based epidemiological studies of hepatosplenic T-cell lymphoma (HSTCL), we undertook a population-based study of ICD-O-3-coded HSTCL in England. We used the National Cancer Registration Dataset and linke... Read More about Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma.