Skip to main content

Research Repository

Advanced Search

All Outputs (121)

Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study (2023)
Journal Article
Jack, R. H., Joseph, R. M., Coupland, C. A., Hall, C. L., & Hollis, C. (2023). Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study. eClinicalMedicine, 57, Article 101857. https://doi.org/10.1016/j.eclinm.2023.101857

Background: Since the onset of the coronavirus (COVID-19) pandemic, clinicians have reported an increase in presentations of sudden and new onset tics particularly affecting teenage girls. This population-based study aimed to describe and compare the... Read More about Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study.

Long-term clinical and cost-effectiveness of a therapist-supported online remote behavioural intervention for tics in children and adolescents: extended 12- and 18-month follow-up of a single-blind randomised controlled trial (2023)
Journal Article
Hollis, C., Hall, C. L., Khan, K., Jones, R., Marston, L., Le Novere, M., Hunter, R., Per Andrén, P., Bennett, S. D., Brown, B. J., Chamberlain, L. R., Davies, E. B., Evans, A., Kouzoupi, N., Mckenzie, C., Sanderson, C., Heyman, I., Kilgariff, J., Glazebrook, C., Mataix-Cols, D., …Murphy, T. (2023). Long-term clinical and cost-effectiveness of a therapist-supported online remote behavioural intervention for tics in children and adolescents: extended 12- and 18-month follow-up of a single-blind randomised controlled trial. Journal of Child Psychology and Psychiatry, 64(6), 941-951. https://doi.org/10.1111/jcpp.13756

Background: Little is known about the long-term effectiveness of behavioural therapy for tics. We aimed to assess the long-term clinical and cost-effectiveness of online therapist-supported exposure and response prevention (ERP) therapy for tics 12 a... Read More about Long-term clinical and cost-effectiveness of a therapist-supported online remote behavioural intervention for tics in children and adolescents: extended 12- and 18-month follow-up of a single-blind randomised controlled trial.

Therapist-Supported Internet-Delivered Exposure and Response Prevention for Children and Adolescents with Tourette Syndrome: A Randomized Clinical Trial (2022)
Journal Article
Andrén, P., Holmsved, M., Ringberg, H., Wachtmeister, V., Isomura, K., Aspvall, K., Lenhard, F., Hall, C. L., Davies, B., Murphy, T., Hollis, C., Sampaio, F., Feldman, I., Bottai, M., Serlachius, E., Andersson, E., Fernández De La Cruz, L., & Mataix-Cols, D. (2022). Therapist-Supported Internet-Delivered Exposure and Response Prevention for Children and Adolescents with Tourette Syndrome: A Randomized Clinical Trial. JAMA Network Open, 5(8), Article e2225614. https://doi.org/10.1001/jamanetworkopen.2022.25614

Importance: The availability of behavior therapy for individuals with Tourette syndrome (TS) and chronic tic disorder (CTD) is limited. Objective: To determine the efficacy and cost-effectiveness of internet-delivered exposure and response prevention... Read More about Therapist-Supported Internet-Delivered Exposure and Response Prevention for Children and Adolescents with Tourette Syndrome: A Randomized Clinical Trial.

Making remote measurement technology work in multiple sclerosis, epilepsy and depression: survey of healthcare professionals (2022)
Journal Article
Andrews, J. A., Craven, M. P., Lang, A. R., Guo, B., Morriss, R., Hollis, C., & RADAR-CNS Consortium. (2022). Making remote measurement technology work in multiple sclerosis, epilepsy and depression: survey of healthcare professionals. BMC Medical Informatics and Decision Making, 22(1), Article 125. https://doi.org/10.1186/s12911-022-01856-z

BACKGROUND: Epilepsy, multiple sclerosis(MS) and depression are long term, central nervous system disorders which have a significant impact on everyday life. Evaluating symptoms of these conditions is problematic and typically involves repeated visit... Read More about Making remote measurement technology work in multiple sclerosis, epilepsy and depression: survey of healthcare professionals.

The COVID-19 pandemic and its impact on tic symptoms in children and young people: a prospective cohort study (2022)
Journal Article
Hall, C. L., Marston, L., Khan, K., Brown, B. J., Sanderson, C., Andrén, P., Bennett, S., Heyman, I., Mataix-Cols, D., Serlachius, E., Hollis, C., & Murphy, T. (2023). The COVID-19 pandemic and its impact on tic symptoms in children and young people: a prospective cohort study. Child Psychiatry and Human Development, 54(6), 1499–1509. https://doi.org/10.1007/s10578-022-01348-1

To understand how children and young people with tic disorders were affected by COVID-19, we compared pre and during pandemic scores on the Yale Global Tic Severity Scale (YGTSS). Participants were young people (N = 112; male:78%; 9–17 years) randomi... Read More about The COVID-19 pandemic and its impact on tic symptoms in children and young people: a prospective cohort study.

Automated virtual reality therapy to treat agoraphobic avoidance and distress in patients with psychosis (gameChange): a multicentre, parallel-group, single-blind, randomised, controlled trial in England with mediation and moderation analyses (2022)
Journal Article
Freeman, D., Lambe, S., Kabir, T., Petit, A., Rosebrock, L., Yu, L.-M., Dudley, R., Chapman, K., Morrison, A., O'Regan, E., Aynsworth, C., Jones, J., Murphy, E., Powling, R., Galal, U., Grabey, J., Rovira, A., Martin, J., Hollis, C., Clark, D. M., …West, J. (2022). Automated virtual reality therapy to treat agoraphobic avoidance and distress in patients with psychosis (gameChange): a multicentre, parallel-group, single-blind, randomised, controlled trial in England with mediation and moderation analyses. Lancet Psychiatry, 9(5), 375-388. https://doi.org/10.1016/S2215-0366%2822%2900060-8

Background
Automated delivery of psychological therapy using immersive technologies such as virtual reality (VR) might greatly increase the availability of effective help for patients. We aimed to evaluate the efficacy of an automated VR cognitive t... Read More about Automated virtual reality therapy to treat agoraphobic avoidance and distress in patients with psychosis (gameChange): a multicentre, parallel-group, single-blind, randomised, controlled trial in England with mediation and moderation analyses.

Factors influencing the efficacy of an online behavioural intervention for children and young people with tics: Process evaluation of a randomised controlled trial (2022)
Journal Article
Khan, K., Hollis, C., Hall, C. L., Davies, E. B., Murray, E., Andrén, P., Mataix-Cols, D., Murphy, T., & Glazebrook, C. (2022). Factors influencing the efficacy of an online behavioural intervention for children and young people with tics: Process evaluation of a randomised controlled trial. Journal of Behavioral and Cognitive Therapy, 32(3), 197-206. https://doi.org/10.1016/j.jbct.2022.02.005

The Online Remote Behavioural Intervention for Tics (ORBIT) trial found that an internet-delivered, therapist-supported, and parent-assisted Exposure and Response Prevention (ERP) intervention reduced tic severity and improved clinical outcomes. This... Read More about Factors influencing the efficacy of an online behavioural intervention for children and young people with tics: Process evaluation of a randomised controlled trial.

Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., Hippisley-Cox, J., & Coupland, C. (2022). Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records. Evidence-Based Mental Health, 25(4), 169-176. https://doi.org/10.1136/ebmental-2021-300355

BACKGROUND: Studies report an increased risk of self-harm or suicide in people prescribed mirtazapine compared with other antidepressants. OBJECTIVES: To compare the risk of serious self-harm in people prescribed mirtazapine versus other antidepressa... Read More about Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records.

The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., Hippisley-Cox, J., & Coupland, C. (2022). The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records. BMC Medicine, 20(1), Article 43. https://doi.org/10.1186/s12916-022-02247-x

Background
Studies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults prescribed mirtazapine or other s... Read More about The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records.

Treatment adherence might be the key to online Exposure and Response Prevention for paediatric tics – Authors' reply (2022)
Journal Article
Hollis, C., Hall, C. L., Marston, L., & ORBIT Trial Team. (2022). Treatment adherence might be the key to online Exposure and Response Prevention for paediatric tics – Authors' reply. Lancet Psychiatry, 9(2), 106-107. https://doi.org/10.1016/S2215-0366%2821%2900503-4

We thank Qianzhi Wang and colleagues for their endorsement of the ORBIT trial1, 2 and for acknowledging the importance of the findings. We are grateful for the opportunity to clarify the issue of adherence within the trial, which we believe to be a... Read More about Treatment adherence might be the key to online Exposure and Response Prevention for paediatric tics – Authors' reply.

Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions (2021)
Journal Article
Bellato, A., Arora, I., Kochhar, P., Ropar, D., Hollis, C., & Groom, M. J. (2022). Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions. Journal of Autism and Developmental Disorders, 52, 4679-4691. https://doi.org/10.1007/s10803-021-05244-w

Despite overlaps in clinical symptomatology, autism and ADHD may be associated with opposite autonomic arousal profiles which might partly explain altered cognitive and global functioning. We investigated autonomic arousal in 106 children/adolescents... Read More about Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions.

The impact of data from remote measurement technology on the clinical practice of healthcare professionals in depression, epilepsy and multiple sclerosis: survey (2021)
Journal Article
Andrews, J. A., Craven, M. P., Lang, A. R., Guo, B., Morriss, R., Hollis, C., & The RADAR-CNS Consortium. (2021). The impact of data from remote measurement technology on the clinical practice of healthcare professionals in depression, epilepsy and multiple sclerosis: survey. BMC Medical Informatics and Decision Making, 21, Article 282. https://doi.org/10.1186/s12911-021-01640-5

Background: A variety of smartphone apps and wearables are available both to help patients monitor their health and to support health care professionals (HCPs) in providing clinical care. As part of the RADAR-CNS consortium, we have conducted researc... Read More about The impact of data from remote measurement technology on the clinical practice of healthcare professionals in depression, epilepsy and multiple sclerosis: survey.

Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial (2021)
Journal Article
Andrén, P., Fernández De La Cruz, L., Isomura, K., Lenhard, F., Hall, C. L., Davies, E. B., Murphy, T., Hollis, C., Sampaio, F., Feldman, I., Bottai, M., Serlachius, E., Andersson, E., & Mataix-Cols, D. (2021). Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial. Trials, 22, Article 669. https://doi.org/10.1186/s13063-021-05592-z

Background
Treatment guidelines recommend behaviour therapy (BT) for patients with Tourette syndrome (TS) and chronic tic disorder (CTD). However, BT is rarely accessible due to limited availability of trained therapists and long travel distances to... Read More about Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial.

Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial (2021)
Journal Article
Andrén, P., de la Cruz, L. F., Isomura, K., Lenhard, F., Hall, C. L., Davies, E. B., Murphy, T., Hollis, C., Sampaio, F., Feldman, I., Bottai, M., Serlachius, E., Andersson, E., & Mataix-Cols, D. (2021). Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial. Trials, 22, Article 669. https://doi.org/10.1186/s13063-021-05592-z

Background: Treatment guidelines recommend behaviour therapy (BT) for patients with Tourette syndrome (TS) and chronic tic disorder (CTD). However, BT is rarely accessible due to limited availability of trained therapists and long travel distances to... Read More about Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial.

Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial (2021)
Journal Article
Hollis, C., Hall, C. L., Jones, R., Marston, L., Novere, M. L., Hunter, R., Brown, B. J., Sanderson, C., Andrén, P., Bennett, S. D., Chamberlain, L. R., Davies, E. B., Evans, A., Kouzoupi, N., McKenzie, C., Heyman, I., Khan, K., Kilgariff, J., Glazebrook, C., Mataix-Cols, D., …Murray, E. (2021). Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial. Lancet Psychiatry, 8(10), 871-882. https://doi.org/10.1016/S2215-0366%2821%2900235-2

Background: Exposure and Response Prevention (ERP) is a form of behavioural therapy for tics; however, its effectiveness remains uncertain. We aimed to evaluate the effectiveness of internet-delivered, therapist-supported, and parent-assisted ERP for... Read More about Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial.

Fidelity of delivery and contextual factors influencing children’s level of engagement: Process evaluation of the Online Remote Behavioural Intervention for Tics (ORBIT) Trial (2021)
Journal Article
Khan, K., Hollis, C., Hall, C., Murray, E., Davies, E., Andrén, P., Mataix-Cols, D., Murphy, T., & Glazebrook, C. (2021). Fidelity of delivery and contextual factors influencing children’s level of engagement: Process evaluation of the Online Remote Behavioural Intervention for Tics (ORBIT) Trial. Journal of Medical Internet Research, 23(6), Article e25470. https://doi.org/10.2196/25470

Background:
The Online Remote Behavioral Intervention for Tics (ORBIT) study was a multicenter randomized controlled trial of a complex intervention that consisted of a web-based behavioral intervention for children and young people with tic disorde... Read More about Fidelity of delivery and contextual factors influencing children’s level of engagement: Process evaluation of the Online Remote Behavioural Intervention for Tics (ORBIT) Trial.

Fidelity of Delivery and Contextual Factors Influencing Children’s Level of Engagement: Process Evaluation of the Online Remote Behavioral Intervention for Tics Trial (2021)
Journal Article
Khan, K., Hollis, C., Hall, C. L., Murray, E., Davies, E. B., Andrén, P., Mataix-Cols, D., Murphy, T., & Glazebrook, C. (2021). Fidelity of Delivery and Contextual Factors Influencing Children’s Level of Engagement: Process Evaluation of the Online Remote Behavioral Intervention for Tics Trial. Journal of Medical Internet Research, 23(6), Article e25470. https://doi.org/10.2196/25470

Background: The Online Remote Behavioral Intervention for Tics (ORBIT) study was a multicenter randomized controlled trial of a complex intervention that consisted of a web-based behavioral intervention for children and young people with tic disorder... Read More about Fidelity of Delivery and Contextual Factors Influencing Children’s Level of Engagement: Process Evaluation of the Online Remote Behavioral Intervention for Tics Trial.

Correction to: Optimising medication management in children and young people with ADHD using a computerised test (QbTest): a feasibility randomised controlled trial (2021)
Journal Article
Williams, L., Hall, C. L., Brown, S., Guo, B., James, M., Franceschini, M., Clarke, J., Selby, K., Vijayan, H., Kulkarni, N., Brown, N., Sayal, K., Hollis, C., & Groom, M. J. (2021). Correction to: Optimising medication management in children and young people with ADHD using a computerised test (QbTest): a feasibility randomised controlled trial. Pilot and Feasibility Studies, 7, Article 94. https://doi.org/10.1186/s40814-021-00830-2

What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism? (2021)
Journal Article
Arora, I., Bellato, A., Gliga, T., Ropar, D., Kochhar, P., Hollis, C., & Groom, M. (2022). What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism?. Journal of Autism and Developmental Disorders, 52(2), 600–616. https://doi.org/10.1007/s10803-021-04961-6

Slower habituation to repeating stimuli characterises Autism, but it is not known whether this is driven by difficulties with information processing or an attentional bias towards sameness. We conducted eye-tracking and presented looming geometrical... Read More about What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism?.