Skip to main content

Research Repository

Advanced Search

All Outputs (65)

European Respiratory Society guideline on long term management of children with bronchopulmonary dysplasia (2019)
Journal Article
Duijts, L., van Meel, E. R., Moschino, L., Baraldi, E., Barnhoorn, M., Bramer, W. M., Bolton, C. E., Boyd, J., Buchval, F., del Cerro, M. J., Colin, A. A., Ersu, R., Greenough, A., Gremmen, C., Halvorson, T., Kamphuis, J., Kotecha, S., Rooney-Otero, K., Schulzke, S., Wilson, A., …Pijnenburg, M. W. (2020). European Respiratory Society guideline on long term management of children with bronchopulmonary dysplasia. European Respiratory Journal, 55(1), Article 1900788. https://doi.org/10.1183/13993003.00788-2019

This document provides recommendations for monitoring and treatment of children in whom bronchopulmonary dysplasia (BPD) has been established and were discharged from the hospital, or who were older than 36 weeks of postmenstrual age. The guideline w... Read More about European Respiratory Society guideline on long term management of children with bronchopulmonary dysplasia.

Building toolkits for COPD exacerbations: lessons from the past and present (2019)
Journal Article
Sapey, E., Bafadhel, M., Bolton, C. E., Wilkinson, T., Hurst, J. R., & Quint, J. K. (2019). Building toolkits for COPD exacerbations: lessons from the past and present. Thorax, 74(9), 898-905. https://doi.org/10.1136/thoraxjnl-2018-213035

In the nineteenth century, it was recognised that acute attacks of chronic bronchitis were harmful. 140 years later, it is clearer than ever that exacerbations of chronic obstructive pulmonary disease (ECOPD) are important events. They are associated... Read More about Building toolkits for COPD exacerbations: lessons from the past and present.

A Specific Proteinase 3 Activity Footprint in Alpha-1-antitrypsin Deficiency (2019)
Journal Article
Newby, P. R., Crossley, D., Crisford, H., Stockley, J. A., Mumford, R. A., Carter, R. I., Bolton, C. E., Hopkinson, N. S., Mahadeva, R., Steiner, M. C., Wilkinson, T. M., Sapey, E., & Stockley, R. A. (2019). A Specific Proteinase 3 Activity Footprint in Alpha-1-antitrypsin Deficiency. ERJ Open Research, 5(3), Article 00095-2019. https://doi.org/10.1183/23120541.00095-2019

Alpha-1-antitrypsin deficiency is a risk factor for emphysema due to tissue damage by serine proteases. Neutrophil elastase has long been considered the enzyme responsible. However, proteinase 3 also produces the pathological features of Chronic Obst... Read More about A Specific Proteinase 3 Activity Footprint in Alpha-1-antitrypsin Deficiency.

Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review (2019)
Journal Article
Pick, H. J., Bolton, C. E., Lim, W. S., & McKeever, T. M. (2019). Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review. European Respiratory Journal, 53(3), Article 1802165. https://doi.org/10.1183/13993003.02165-2018

Symptomatic and functional recovery are important patient-reported outcome measures (PROMs) in community-acquired pneumonia (CAP) that are increasingly used as trial endpoints. This systematic review summarises the literature on PROMs in CAP.

Comp... Read More about Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review.

Hip fracture outcomes in patients with COPD (2018)
Journal Article
Buss, L., McKeever, T. M., Nightingale, J., Akyea, R., Ollivere, B., Moppett, I., & Bolton, C. E. (2018). Hip fracture outcomes in patients with COPD. British Journal of Anaesthesia, 121(6), 1377-1379. https://doi.org/10.1016/j.bja.2018.09.008+hideArticle+Info

Hip fractures are common in patients with COPD and contemporary outcome data is needed. Patients admitted with a hip fracture to one acute trust (2010-2015) were assessed prospectively (UK National Hip Fracture Database audit) and mortality data col... Read More about Hip fracture outcomes in patients with COPD.

TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations (2018)
Journal Article
Mallia-Milanes, B., Dufour, A., Philp, C., Solis, N., Klein, T., Fischer, M., Bolton, C. E., Shapiro, S., Overall, C. M., & Johnson, S. R. (2018). TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations. AJP - Lung Cellular and Molecular Physiology, 315(6), L1003-L1014. https://doi.org/10.1152/ajplung.00175.2018

© 2018 the American Physiological Society. Dys-regulated protease activity is thought to cause parenchymal and airway damage in chronic obstructive pulmonary disease (COPD). Multiple proteases have been implicated in COPD, and identifying their subst... Read More about TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations.

Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study (2018)
Journal Article
Mohan, D., Forman, J. R., Allinder, M., McEniery, C. M., Bolton, C. E., Cockcroft, J. R., MacNee, W., Fuld, J., Marchong, M., Gale, N. S., Fisk, M., Nagarajan, S., Cheriyan, J., Lomas, D. A., Calverley, P. M., Miller, B. E., Tal-Singer, R., Wilkinson, I. B., & Polkey, M. I. (2018). Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study. Thorax, 73(12), 1182-1185. https://doi.org/10.1136/thoraxjnl-2018-211556

Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine whether aortic stiffness and... Read More about Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.

Risk of fall in patients with COPD (2018)
Journal Article
Hakamy, A., Bolton, C. E., Gibson, J. E., & McKeever, T. M. (2018). Risk of fall in patients with COPD. Thorax, 73(11), 1079-1080. https://doi.org/10.1136/thoraxjnl-2017-211008

A matched cohort study was conducted to determine the incidence of falls in patients following a diagnosis of COPD using a UK primary care database. 44 400 patients with COPD and 175 545 non-COPD subjects were identified. The incidence rate of fall p... Read More about Risk of fall in patients with COPD.

Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy (2018)
Journal Article
Thomson, R. J., Aung, N., Sanghvi, M. M., Paiva, J. M., Lee, A. M., Fung, K., Pfeffer, P. E., Mackay, A. J., Mckeever, T. M., Lukaschuk, E. 5., Carapella, V., Kim, Y. J., Bolton, C. E., Piechnik, S. K., Neubauer, S., & Petersen, S. E. (2018). Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy. PLoS ONE, 13(3), Article e0194434. https://doi.org/10.1371/journal.pone.0194434

Background

Reduced lung function is common and associated with increased cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung fu... Read More about Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy.

The recording and characteristics of pulmonary rehabilitation in patients with COPD using The Health Information Network (THIN) primary care database (2017)
Journal Article
Hakamy, A., McKeever, T. M., Gibson, J. E., & Bolton, C. E. (in press). The recording and characteristics of pulmonary rehabilitation in patients with COPD using The Health Information Network (THIN) primary care database. npj Primary Care Respiratory Medicine, 27(1), Article 58. https://doi.org/10.1038/s41533-017-0058-2

Pulmonary rehabilitation is recommended for patients with COPD to improve physical function, breathlessness and quality of life. Using The Health Information Network (THIN) primary care database in UK, we compared the demographic and clinical paramet... Read More about The recording and characteristics of pulmonary rehabilitation in patients with COPD using The Health Information Network (THIN) primary care database.

Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease (2017)
Journal Article
Shindi, R., Al-Mehairi, A., Negm, O. H., Kalsheker, N., Gale, N., Shale, D. J., Harrison, T. W., Bolton, C. E., John, M., Todd, I., Tighe, P. J., & Fairclough, L. C. (2017). Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease. Clinical Immunology, 183, https://doi.org/10.1016/j.clim.2017.09.020

Autoimmunity occurs in chronic obstructive pulmonary disease (COPD). We describe an antigen microarray for detecting serum autoantibodies (AAbs) to determine how IgM, as well as IgG, AAbs distinguish patients with COPD from controls with a history of... Read More about Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease.

The use of the practice walk test in pulmonary rehabilitation program: National COPD Audit Pulmonary Rehabilitation Workstream (2017)
Journal Article
Hakamy, A., McKeever, T. M., Steiner, M. C., Roberts, C. M., Singh, S. J., & Bolton, C. E. (in press). The use of the practice walk test in pulmonary rehabilitation program: National COPD Audit Pulmonary Rehabilitation Workstream. International Journal of Chronic Obstructive Pulmonary Disease, 12, https://doi.org/10.2147/COPD.S141620

Our aim was to evaluate the use and impact of the practice walk test on enrolment, completion, and clinical functional response to pulmonary rehabilitation (PR) using the 2015 UK National Chronic Obstructive Pulmonary Disease (COPD) Pulmonary Rehabil... Read More about The use of the practice walk test in pulmonary rehabilitation program: National COPD Audit Pulmonary Rehabilitation Workstream.

Socioeconomic deprivation and the outcome of pulmonary rehabilitation in England and Wales (2017)
Journal Article
Steiner, M. C., Lowe, D., Beckford, K., Blakey, J., Bolton, C. E., Elkin, S., Man, W. D. .-C., Roberts, C. M., Sewell, L., Walker, P., & Singh, S. J. (2017). Socioeconomic deprivation and the outcome of pulmonary rehabilitation in England and Wales. Thorax, 72(6), 530-537. https://doi.org/10.1136/thoraxjnl-2016-209376

Background: Pulmonary rehabilitation (PR) improves exercise capacity and health status in patients with COPD, but many patients assessed for PR do not complete therapy. It is unknown whether socioeconomic deprivation associates with rates of completi... Read More about Socioeconomic deprivation and the outcome of pulmonary rehabilitation in England and Wales.

The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro (2016)
Journal Article
Miller, S., Henry, A. P., Hodge, E., Kheirallah, A. K., Billington, C. K., Rimington, T. L., Bhaker, S. K., Obeidat, M., Melén, E., Merid, S. K., Swan, C., Gowland, C., Nelson, C. P., Stewart, C. E., Bolton, C. E., Kilty, I., Malarstig, A., Parker, S. G., Moffatt, M. F., Wardlaw, A. J., …Sayers, I. (2016). The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro. PLoS ONE, 11(10), Article e0164041. https://doi.org/10.1371/journal.pone.0164041

Introduction

Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the Advanced Glycation End Product Recepto... Read More about The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro.

The effect of pulmonary rehabilitation on mortality, balance, and risk of fall in stable patients with chronic obstructive pulmonary disease: a systematic review (2016)
Journal Article
Hakamy, A., Bolton, C. E., & McKeever, T. M. (2017). The effect of pulmonary rehabilitation on mortality, balance, and risk of fall in stable patients with chronic obstructive pulmonary disease: a systematic review. Chronic Respiratory Disease, 14(1), https://doi.org/10.1177/1479972316661925

Objectives: To evaluate the impact of pulmonary rehabilitation on survival and fall (including balance) in patients with chronic obstructive pulmonary disease (COPD) at stability.

Design: Systematic Review.

Methods: OVID, MEDLINE, EMBASE, and... Read More about The effect of pulmonary rehabilitation on mortality, balance, and risk of fall in stable patients with chronic obstructive pulmonary disease: a systematic review.

Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease (2016)
Journal Article
Selvarajah, S., Todd, I., Tighe, P. J., John, M., Bolton, C. E., Harrison, T. W., & Fairclough, L. C. (2016). Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease. Mediators of Inflammation, 2016, 1-9. https://doi.org/10.1155/2016/3604842

Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multipl... Read More about Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease.

Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD (2016)
Journal Article
Rabinovich, R. A., Miller, B. E., Wrobel, K., Ranjit, K., Williams, M. C., Drost,, E., Edwards, L. D., Lomas, D. A., Rennard, S. I., Agustí, A., Tal-Singer, R., Vestbo, J., Wouters, E. F., John, M., van Beek, E. J., Murchison, J. T., Bolton, C. E., MacNee, W., & Huang, J. T. (in press). Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD. European Respiratory Journal, 47(5), https://doi.org/10.1183/13993003.01824-2015

Elastin degradation is a key feature of emphysema and may have a role in the pathogenesis of atherosclerosis associated with chronic obstructive pulmonary disease (COPD). Circulating desmosine is a specific biomarker of elastin degradation. We invest... Read More about Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD.