All Outputs (65)

Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19 (2022)
Journal Article
Houchen-Wolloff, L., Poinasamy, K., Holmes, K., Tarpey, M., Hastie, C., Raihani, K., Rogers, N., Smith, N., Adams, D., Burgess, P., Clark, J., Cranage, C., Desai, M., Geary, N., Gill, R., Mangwani, J., Staunton, L., Berry, C., Bolton, C. E., Chalder, T., …Evans, R. A. (2022). Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19. Thorax, 77(7), 717-720. https://doi.org/10.1136/thoraxjnl-2021-218582

Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts,... Read More about Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19.

Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis (2022)
Preprint / Working Paper
Middleton, S., Chalitsios, C., McKeever, T. M., Jenkins, A. R., & Bolton, C. E. Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis

Background Acute COVID-19 clinical symptoms have been clearly documented, but long-term functional and symptomatic recovery from COVID -19 is less well described.

Methods A systematic review and meta-analysis were conducted to describe patient-rep... Read More about Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis.

Patient-related outcomes in patients referred to a respiratory clinic with persisting symptoms following non-hospitalised COVID-19 (2022)
Journal Article
Harvey-Dunstan, T. C., Jenkins, A. R., Gupta, A., Hall, I. P., & Bolton, C. E. (2022). Patient-related outcomes in patients referred to a respiratory clinic with persisting symptoms following non-hospitalised COVID-19. Chronic Respiratory Disease, 19, 1-4. https://doi.org/10.1177/14799731211069391

Survivors of COVID-19 can present with varied and persisting symptoms, regardless of hospitalisation. We describe the ongoing symptoms, quality of life and return to work status in a cohort of non-hospitalised COVID-19 survivors with persisting respi... Read More about Patient-related outcomes in patients referred to a respiratory clinic with persisting symptoms following non-hospitalised COVID-19.

Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD (2021)
Journal Article
Latimer, L. E., Constantin-Teodosiu, D., Popat, B., Constantin, D., Houchen-Wolloff, L., Bolton, C. E., Steiner, M. C., & Greenhaff, P. L. (2022). Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD. European Respiratory Journal, 59(5), Article 2101507. https://doi.org/10.1183/13993003.01507-2021

BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients exhibit lower peak oxygen uptake (V'O2peak), altered muscle metabolism and impaired exercise tolerance compared with age-matched controls. Whether these traits reflect muscle-level dec... Read More about Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD.

Developing good practice by understanding how UK medical schools address low level concerns: a survey study (2021)
Journal Article
Vivekananda-Schmidt, P., Bolton, C., & Knox, R. (2022). Developing good practice by understanding how UK medical schools address low level concerns: a survey study. Education for Primary Care, 33(1), 6-12. https://doi.org/10.1080/14739879.2021.1948805

In the literature, a distinction is made between low-level concerns and what is regarded as fitness to practise concerns. The General Medical Council expects all UK medical schools to have a transparent process in place about how concerns about its m... Read More about Developing good practice by understanding how UK medical schools address low level concerns: a survey study.

Improving lung health in low-income and middle-income countries: from challenges to solutions (2021)
Journal Article
Meghji, J., Mortimer, K., Agusti, A., Allwood, B. W., Asher, I., Bateman, E. D., Bissell, K., Bolton, C. E., Bush, A., Celli, B., Chiang, C.-Y., Cruz, A. A., Dinh-Xuan, A.-T., El Sony, A., Fong, K. M., Fujiwara, P. I., Gaga, M., Garcia-Marcos, L., Halpin, D. M. G., Hurst, J. R., …Marks, G. B. (2021). Improving lung health in low-income and middle-income countries: from challenges to solutions. Lancet, 397(10277), 928-940. https://doi.org/10.1016/S0140-6736%2821%2900458-X

Low-income and middle-income countries (LMICs) bear a disproportionately high burden of the global morbidity and mortality caused by chronic respiratory diseases (CRDs), including asthma, chronic obstructive pulmonary disease, bronchiectasis, and pos... Read More about Improving lung health in low-income and middle-income countries: from challenges to solutions.

The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP) (2021)
Journal Article
Pick, H., Faghy, M., Cresswell, G., Ashton, D., Bolton, C., McKeever, T., Lim, W., & Bewick, T. (2021). The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP). Advances in Respiratory Medicine, 89, 216-220. https://doi.org/10.5603/ARM.a2021.0002

Background: Patients experience substantial morbidity following discharge from hospital and during recovery from community-acquired pneumonia (CAP). Inspiratory muscle training (IMT) has demonstrated improved functional capacity and reduced patient-r... Read More about The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP).

The burden of chronic respiratory diseases in adults in Nepal: A systematic review (2021)
Journal Article
Ekezie, W., Jenkins, A. R., Hall, I. P., Evans, C., Koju, R., Kurmi, O. P., & Bolton, C. E. (2021). The burden of chronic respiratory diseases in adults in Nepal: A systematic review. Chronic Respiratory Disease, 18, 1-20. https://doi.org/10.1177/1479973121994572

While chronic lung disease causes substantial global morbidity and mortality, global estimates have primarily been based on broad assumptions. Specific country data from low-income countries such as Nepal are limited. This review assessed primary evi... Read More about The burden of chronic respiratory diseases in adults in Nepal: A systematic review.

Cardiovascular risk prediction using physical performance measures in COPD: results from a multicentre observational study (2020)
Journal Article
Fermont, J. M., Fisk, M., Bolton, C. E., MacNee, W., Cockcroft, J. R., Fuld, J., Cheriyan, J., Mohan, D., Mäki-Petäjä, K. M., Al-Hadithi, A. B., Tal-Singer, R., Müllerova, H., Polkey, M. I., Wood, A. M., McEniery, C. M., & Wilkinson, I. B. (2020). Cardiovascular risk prediction using physical performance measures in COPD: results from a multicentre observational study. BMJ Open, 10(12), Article e038360. https://doi.org/10.1136/bmjopen-2020-038360

Objectives Although cardiovascular disease (CVD) is a common comorbidity associated with chronic obstructive pulmonary disease (COPD), it is unknown how to improve prediction of cardiovascular (CV) risk in individuals with COPD. Traditional CV risk s... Read More about Cardiovascular risk prediction using physical performance measures in COPD: results from a multicentre observational study.

Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study (2020)
Journal Article
Siraj, R., McKeever, T., Gibson, J., Gordon, A., & Bolton, C. (2021). Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study. Respiratory Medicine, 177, Article 106288. https://doi.org/10.1016/j.rmed.2020.106288

Background: Although cognitive impairment and dementia are common comorbidities in patients with chronic obstructive pulmonary disease (COPD), estimates of incidence following a diagnosis of COPD are inconclusive. Objective: To determine the incidenc... Read More about Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study.

British Thoracic Society survey of rehabilitation to support recovery of the post-COVID- 19 population (2020)
Journal Article
Singh, S. J., Barradell, A. C., Greening, N. J., Bolton, C., Jenkins, G., Preston, L., & Hurst, J. R. (2020). British Thoracic Society survey of rehabilitation to support recovery of the post-COVID- 19 population. BMJ Open, 10(12), Article e040213. https://doi.org/10.1136/bmjopen-2020-040213

Objective A proportion of those recovering from COVID-19 are likely to have significant and ongoing symptoms, functional impairment and psychological disturbances. There is an immediate need to develop a safe and efficient discharge process and recov... Read More about British Thoracic Society survey of rehabilitation to support recovery of the post-COVID- 19 population.

Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease (2020)
Journal Article
Fermont, J. M., Mohan, D., Fisk, M., Bolton, C. E., Macnee, W., Cockcroft, J. R., McEniery, C., Fuld, J., Cheriyan, J., Tal-Singer, R., Müllerova, H., Wood, A. M., Wilkinson, I. B., & Polkey, M. I. (2021). Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease. Age and Ageing, 50(3), 795-801. https://doi.org/10.1093/ageing/afaa138

RATIONALE: chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and common in older adults. The BODE Index is the most recognised mortality risk score in COPD but includes a 6-minute walk test (6MWT) that is seldom available i... Read More about Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease.

Submaximal Eccentric Cycling in People With COPD: Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses (2020)
Journal Article
Ward, T. J. C., Lindley, M. R., Ferguson, R. A., Constantin, D., Singh, S. J., Bolton, C. E., Evans, R. A., Greenhaff, P. L., & Steiner, M. C. (2021). Submaximal Eccentric Cycling in People With COPD: Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses. Chest, 159(2), 564-574. https://doi.org/10.1016/j.chest.2020.08.2082

© 2020 American College of Chest Physicians Background: Eccentric cycling (ECC) may be an attractive exercise method in COPD because of both low cardiorespiratory demand and perception of effort compared with conventional concentric cycling (CON) at... Read More about Submaximal Eccentric Cycling in People With COPD: Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses.

Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study (2020)
Journal Article
Safavi, S., Arthofer, C., Cooper, A., Harkin, J. W., Prayle, A. P., Sovani, M. P., Bolton, C. E., Gowland, P. A., & Hall, I. P. (2020). Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study. European Journal of Radiology, 130, Article 109196. https://doi.org/10.1016/j.ejrad.2020.109196

Purpose
The diaphragm is the most important muscle of respiration. Disorders of the diaphragm can have a deleterious impact on respiratory function. We aimed to evaluate the use of an open-configuration upright low-field MRI system to assess diaphra... Read More about Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study.

Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative (2020)
Journal Article
Crossley, D., Stockley, J., Bolton, C. E., Hopkinson, N. S., Mahadeva, R., Steiner, M., Wilkinson, T., Hurst, J. R., Gooptu, B., & Stockley, R. A. (2020). Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative. BMJ Open, 10(6), Article e036045. https://doi.org/10.1136/bmjopen-2019-036045

Objectives To establish a database network for the study of alpha-1 antitrypsin deficiency (AATD) and compare the results to CT lung density as the most direct measure of emphysema.

Design A central electronic database was established to permit th... Read More about Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative.

Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement (2020)
Journal Article
Gupta, A., Jayes, L. R., Holmes, S., Sahota, O., Canavan, M., Elkin, S. L., Lim, K., Murphy, A. C., Singh, S., Towlson, E. A., Ward, H., Scullion, J., McKeever, T. M., & Bolton, C. E. (2020). Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement. International Journal of Chronic Obstructive Pulmonary Disease, 15, 1377-1390. https://doi.org/10.2147/copd.s233398

Introduction: Osteoporosis and bone fractures are common in chronic obstructive pulmonary disease (COPD) and contribute significantly to morbidity and mortality. Current national guidance on COPD management recommends addressing bone health in patien... Read More about Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement.

Respiratory and Cardiovascular Outcomes in Survivors of Extremely Preterm Birth at 19 Years (2020)
Journal Article
Hurst, J. R., Beckmann, J., Ni, Y., Bolton, C. E., McEniery, C. M., Cockcroft, J. R., & Marlow, N. (2020). Respiratory and Cardiovascular Outcomes in Survivors of Extremely Preterm Birth at 19 Years. American Journal of Respiratory and Critical Care Medicine, 202(3), 422-432. https://doi.org/10.1164/rccm.202001-0016oc

Rationale: Growth and development during adolescence may modify the respiratory and vascular differences seen among extremely preterm (EP) individuals in childhood and early adolescence.

Objective: To assess the trajectory of respiratory and cardi... Read More about Respiratory and Cardiovascular Outcomes in Survivors of Extremely Preterm Birth at 19 Years.

Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study (2020)
Journal Article
Fermont, J. M., Bolton, C. E., Fisk, M., Mohan, D., Macnee, W., Cockcroft, J. R., McEniery, C., Fuld, J., Cheriyan, J., Tal-Singer, R., Wilkinson, I. B., Wood, A. M., Polkey, M. I., & Müllerova, H. (2020). Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study. PLoS ONE, 15(2), e0228940. https://doi.org/10.1371/journal.pone.0228940

In chronic obstructive pulmonary disease (COPD), acute exacerbation of COPD requiring hospital admission is associated with mortality and healthcare costs. The ERICA study assessed multiple clinical measures in people with COPD, including the short... Read More about Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study.

Highlights 2019: fresh focus on health (2019)
Journal Article
Palmer, J., Bolton, C. E., Shrestha, P., Adhikari, P., & Karmacharya, B. (2019). Highlights 2019: fresh focus on health. Lancet, 394(10216), 2219-2236. https://doi.org/10.1016/s0140-6736%2819%2933060-0

Contribution towards

Fresh focus on health: Highlights 2019 photography competition open for submissions.
Palmer J.
Lancet. 2019 Jun 8;393(10188):2284-2285. doi: 10.1016/S0140-6736(19)31258-9. Epub 2019 Jun 6

https://www.ncbi.nlm.nih.gov/pubm... Read More about Highlights 2019: fresh focus on health.

Is targeted lung cancer screening an opportune time to address cardiovascular risk? (2019)
Journal Article
Fisk, M., & Bolton, C. E. (2019). Is targeted lung cancer screening an opportune time to address cardiovascular risk?. Thorax, 74(12), 1107-1108. https://doi.org/10.1136/thoraxjnl-2019-213790