All Outputs (8)

Nepal Family Cohort study: a study protocol (2024)
Journal Article
Kurmi, O. P., Chaudhary, N., Delanerolle, G., Bolton, C. E., Pant, P. R., Regmi, P. R., Gautam, S., Satia, I., Simkhada, P., Kyrou, I., Sigdel, T. K., Hundley, V., Dali, P. R., Løkke, A., Lam, K. B. H., Bennett, D., Custovic, A., van Teijlingen, E., Gill, P., Randeva, H., & O'Byrne, P. (2024). Nepal Family Cohort study: a study protocol. BMJ Open, 14(11), Article e088896. https://doi.org/10.1136/bmjopen-2024-088896

INTRODUCTION: The Nepal Family Cohort study uses a life course epidemiological approach to collect comprehensive data on children's and their parents' environmental, behavioural and metabolic risk factors. These factors can affect the overall develop... Read More about Nepal Family Cohort study: a study protocol.

Mirtazapine to alleviate severe breathlessness in patients with COPD or interstitial lung diseases (BETTER-B): an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial. (2024)
Journal Article
Higginson, I. J., Brown, S. T., Oluyase, A. O., May, P., Maddocks, M., Costantini, M., Bajwah, S., Normand, C., Bausewein, C., Simon, S. T., Ryan, K., Currow, D. C., Johnson, M. J., Hart, S. P., Mather, H., Krajnik, M., Tanzi, S., Ghirotto, L., Bolton, C. E., Janowiak, P., …Brown, J. M. (2024). Mirtazapine to alleviate severe breathlessness in patients with COPD or interstitial lung diseases (BETTER-B): an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial. Lancet Respiratory Medicine, 12(10), 763-774. https://doi.org/10.1016/s2213-2600%2824%2900187-5

Background

Breathlessness frequently becomes severe among people with respiratory disease. Mirtazapine, a widely used antidepressant, has shown promise in the modulation of respiratory sensation and the response to it, as well as reducing feelings... Read More about Mirtazapine to alleviate severe breathlessness in patients with COPD or interstitial lung diseases (BETTER-B): an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial..

Erratum: Structural Predictors of Lung Function Decline in Young Smokers with Normal Spirometry (2024)
Journal Article
Ritchie, A. I., Donaldson, G. C., Hoffman, E. A., Allinson, J. P., Bloom, C. I., Bolton, C. E., Choudhury, G., Gerard, S. E., Guo, J., Alves-Moreira, L., McGarvey, L., Sapey, E., Stockley, R. A., Yip, K., Singh, D., Wilkinson, T., Fageras, M., Ostridge, K., Jöns, O., Bucchioni, E., …Wedzicha, J. A. (2024). Erratum: Structural Predictors of Lung Function Decline in Young Smokers with Normal Spirometry. American Journal of Respiratory and Critical Care Medicine, 210(2), 249. https://doi.org/10.1164/rccm.v209erratum11

There is an error in the article by Ritchie and colleagues (1), published in the May 15, 2024 issue of the Journal. In the second sentence in the Figure 3 legend, the midcoronal section from the nonsmoking subject is incorrectly identified as the pane... Read More about Erratum: Structural Predictors of Lung Function Decline in Young Smokers with Normal Spirometry.

DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19 (2024)
Journal Article
Gupta, A., Nicholas, R., McGing, J. J., Nixon, A. V., Mallinson, J. E., McKeever, T. M., Bradley, C. R., Piasecki, M., Cox, E. F., Bonnington, J., Lord, J. M., Brightling, C. E., Evans, R. A., Hall, I. P., Francis, S. T., Greenhaff, P. L., & Bolton, C. E. (2024). DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19. Experimental Physiology, 109(8), 1274-1291. https://doi.org/10.1113/ep091590

We evaluated the impacts of COVID-19 on multi-organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular disease were recruited... Read More about DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19.

Free-breathing Functional Pulmonary Proton MRI: A Novel Approach Using Voxel-wise Lung Ventilation (VOLVE) Assessment in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease (2024)
Journal Article
Peggs, Z. J., Brooke, J. P., Bolton, C. E., Hall, I. P., Francis, S. T., & Gowland, P. A. (2024). Free-breathing Functional Pulmonary Proton MRI: A Novel Approach Using Voxel-wise Lung Ventilation (VOLVE) Assessment in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease. Journal of Magnetic Resonance Imaging, 61(2), 663-675. https://doi.org/10.1002/jmri.29444

Background: In respiratory medicine, there is a need for sensitive measures of regional lung function that can be performed using standard imaging technology, without the need for inhaled or intravenous contrast agents. Purpose: To describe VOxel‐wis... Read More about Free-breathing Functional Pulmonary Proton MRI: A Novel Approach Using Voxel-wise Lung Ventilation (VOLVE) Assessment in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease.

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2024)
Journal Article
Shek, N., Choy, A.-M., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., Thomson, N. C., Chalmers, J. D., Bown, M. J., Newby, D. E., Khan, F., & Huang, J. T. J. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), Article 15. https://doi.org/10.1038/s41514-024-00143-7

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and seve... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Accelerated immune ageing is associated with COVID-19 disease severity (2024)
Journal Article
Lord, J. M., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, A. G., Greening, N. J., McAuley, H. J. C., Evans, R. A., Moss, P., Moore, S. C., Turtle, L., Gautam, N., Gilani, A., Bajaj, M., Wain, L. V., Brightling, C., Raman, B., Marks, M., Singapuri, A., Elneima, O., …Bolton, C. E. (2024). Accelerated immune ageing is associated with COVID-19 disease severity. Immunity and Ageing, 21(1), Article 6. https://doi.org/10.1186/s12979-023-00406-z

Background: The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescence and ac... Read More about Accelerated immune ageing is associated with COVID-19 disease severity.

Structural Predictors of Lung Function Decline in Young Smokers with Normal Spirometry (2024)
Journal Article
Ritchie, A. I., Donaldson, G. C., Hoffman, E. A., Allinson, J. P., Bloom, C. I., Bolton, C. E., Choudhury, G., Gerard, S. E., Guo, J., Alves-Moreira, L., McGarvey, L., Sapey, E., Stockley, R. A., Yip, K., Singh, D., Wilkinson, T., Fageras, M., Ostridge, K., Jöns, O., Bucchioni, E., …Wedzicha, J. A. (2024). Structural Predictors of Lung Function Decline in Young Smokers with Normal Spirometry. American Journal of Respiratory and Critical Care Medicine, 209(10), 1208-1218. https://doi.org/10.1164/rccm.202307-1203OC

Rationale: Chronic obstructive pulmonary disease (COPD) due to tobacco smoking commonly presents when extensive lung damage has occurred.

Objectives: We hypothesized that structural change would be detected early in the natural history of COPD and... Read More about Structural Predictors of Lung Function Decline in Young Smokers with Normal Spirometry.