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Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy (2017)
Journal Article
England, J., Loughna, S., & Rutland, C. S. (2017). Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy. Journal of Cardiovascular Development and Disease, 4(3), Article 8. https://doi.org/10.3390/jcdd4030008

Animals have frequently been used as models for human disorders and mutations. Following advances in genetic testing and treatment options, and the decreasing cost of these technologies in the clinic, mutations in both companion and commercial animal... Read More about Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy.

Fatty acids in veterinary medicine and research (2017)
Book Chapter
Rutland, C. S., Mostyn, A., & Simpson, S. (2017). Fatty acids in veterinary medicine and research. In A. Catala (Ed.), Fatty acids. InTechOpen. https://doi.org/10.5772/intechopen.68440

Fatty acid regulation is an essential process for all animals. A number of studies have shown that diet affects the levels/availability of fatty acids in the body but increasingly evidence shows that disease states can alter the amounts within the bo... Read More about Fatty acids in veterinary medicine and research.

Morphological and structural investigations of Egyptian water buffalo (Bubalus Bubalis) sertoli cells (2017)
Journal Article
Rutland, C. S., Derbalah, A., Karam Roshdy, K., & El-Gendy, S. (2017). Morphological and structural investigations of Egyptian water buffalo (Bubalus Bubalis) sertoli cells. Journal of Buffalo Science, 6(1), https://doi.org/10.6000/1927-520X.2017.06.01.1

Buffaloes are essential part of the economy in many countries and provide sustainable food in addition to being working animals. Inefficiency in reproduction has become problematic in recent years due to a number of factors and although much research... Read More about Morphological and structural investigations of Egyptian water buffalo (Bubalus Bubalis) sertoli cells.

Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects (2017)
Journal Article
England, J., Granados-Riveron, J. T., Polo-Parada, L., Kuriakose, D., Moore, C., Brook, J. D., …Loughna, S. (2017). Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects. Journal of Molecular and Cellular Cardiology, 106, https://doi.org/10.1016/j.yjmcc.2017.03.006

Tropomyosin 1 (TPM1) is an essential sarcomeric component, stabilising the thin filament and facilitating actin's interaction with myosin. A number of sarcomeric proteins, such as alpha myosin heavy chain, play crucial roles in cardiac development. M... Read More about Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects.

Genomic insights into cardiomyopathies: a comparative cross-species review (2017)
Journal Article
Simpson, S., Rutland, P., & Rutland, C. S. (2017). Genomic insights into cardiomyopathies: a comparative cross-species review. Veterinary Sciences, 4(1), Article 19. https://doi.org/10.3390/vetsci4010019

n the global human population, the leading cause of non-communicable death is cardiovascular disease. It is predicted that by 2030, deaths attributable to cardiovascular disease will have risen to over 20 million per year. This review compares the ca... Read More about Genomic insights into cardiomyopathies: a comparative cross-species review.

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development (2017)
Journal Article
Metzler, V. M., de Brot, S., Robinson, R. S., Jeyapalan, J. N., Rakha, E., Walton, T., …Mongan, N. P. (2017). Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. Placenta, 56, 79-85. https://doi.org/10.1016/j.placenta.2017.02.018

The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy,... Read More about Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development.

The Effects of Diet on Anatomy, Physiology and Health in the Guinea Pig (2016)
Journal Article
Witkowska, A., Price, J., Hughes, C., Smith, D., White, K., Alibhai, A., & Rutland, C. S. (2017). The Effects of Diet on Anatomy, Physiology and Health in the Guinea Pig. Journal of Animal Health and Behavioural Science, 1(1), 1-6

Given the increasing popularity of the guinea pig as a pet, it is perhaps surprising that relatively little is published as to their husbandry and dietary requirements. Indeed, a review of the literature currently available to owners, scientists and... Read More about The Effects of Diet on Anatomy, Physiology and Health in the Guinea Pig.

Multiple genetic associations with Irish wolfhound dilated cardiomyopathy (2016)
Journal Article
Simpson, S., Dunning, M. D., Brownlie, S., Patel, J., Godden, M., Cobb, M., …Rutland, C. S. (2016). Multiple genetic associations with Irish wolfhound dilated cardiomyopathy. BioMed Research International, 2016(637408), https://doi.org/10.1155/2016/6374082

Cardiac disease is a leading cause of morbidity and mortality in dogs and humans, with dilated cardiomyopathy being a large contributor to this. The Irish Wolfhound (IWH) is one of the most commonly affected breeds and one of the few breeds with gene... Read More about Multiple genetic associations with Irish wolfhound dilated cardiomyopathy.

How does student educational background affect transition into the first year of veterinary school? Academic performance and support needs in university education (2016)
Journal Article
Rutland, C. S., Dobbs, H., & Tötemeyer, S. (in press). How does student educational background affect transition into the first year of veterinary school? Academic performance and support needs in university education. Journal of Veterinary Medical Education, 43(4), https://doi.org/10.3138/jvme.0915-145R1

The first year of university is critical in shaping persistence decisions (whether students continue with and complete their degrees) and plays a formative role in influencing student attitudes and approaches to learning. Previous educational experie... Read More about How does student educational background affect transition into the first year of veterinary school? Academic performance and support needs in university education.

Increased dietary protein in the second trimester of gestation increases live weight gain and carcass composition in weaner calves to 6 months of age (2016)
Journal Article
Miguel-Pacheco, G., Curtain, L., Rutland, C. S., Knott, L., Norman, S., Phillips, N., & Perry, V. (2017). Increased dietary protein in the second trimester of gestation increases live weight gain and carcass composition in weaner calves to 6 months of age. Animal, 11(6), 991-999. https://doi.org/10.1017/S1751731116002330

Genetically similar nulliparous Polled Hereford heifers from a closed pedigree herd were used to evaluate the effects of dietary protein during the first and second trimester of gestation upon fetal, placental and postnatal growth. Heifers were rando... Read More about Increased dietary protein in the second trimester of gestation increases live weight gain and carcass composition in weaner calves to 6 months of age.

Linking bone development on the caudal aspect of the distal phalanx with lameness during life (2016)
Journal Article
Newsome, R., Green, M. J., Bell, N., Chagunda, M., Mason, C., Rutland, C. S., …Huxley, J. (2016). Linking bone development on the caudal aspect of the distal phalanx with lameness during life. Journal of Dairy Science, 99(6), https://doi.org/10.3168/jds.2015-10202

Claw horn disruption lesions (CHDL; sole hemorrhage, sole ulcer, and white line disease) cause a large proportion of lameness in dairy cattle, yet their etiopathogenesis remains poorly understood. Untreated CHDL may be associated with damage to the i... Read More about Linking bone development on the caudal aspect of the distal phalanx with lameness during life.

Genetics of human and canine dilated cardiomyopathy (2015)
Journal Article
Simpson, S., Edwards, J., Ferguson-Mignan, T. F., Cobb, M., Mongan, N. P., & Rutland, C. S. (2015). Genetics of human and canine dilated cardiomyopathy. International Journal of Genomics, 2015, Article 204823. https://doi.org/10.1155/2015/204823

Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in... Read More about Genetics of human and canine dilated cardiomyopathy.

A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data (2015)
Journal Article
Simpson, S., Edwards, J., Emes, R. D., Cobb, M. A., Mongan, N. P., & Rutland, C. S. (2015). A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data. PeerJ, 3, Article e842. https://doi.org/10.7717/peerj.842

Dilated cardiomyopathy is a prevalent and often fatal disease in humans and dogs. Indeed dilated cardiomyopathy is the third most common form of cardiac disease in humans, reported to affect approximately 36 individuals per 100,000 individuals. In do... Read More about A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data.

Computed tomography analysis of guinea pig bone: architecture, bone thickness and dimensions throughout development. (2014)
Journal Article
Witkowska, A., Alibhai, A., Hughes, C., Price, J., Klisch, K., Sturrock, C., & Rutland, C. S. (2014). Computed tomography analysis of guinea pig bone: architecture, bone thickness and dimensions throughout development. PeerJ, 2, Article e615. https://doi.org/10.7717/peerj.615

The domestic guinea pig, Cavia aperea f. porcellus, belongs to the Caviidae family of rodents. It is an important species as a pet, a source of food and in medical research. Adult weight is achieved at 8-12 months and life expectancy is ∼5-6 years. O... Read More about Computed tomography analysis of guinea pig bone: architecture, bone thickness and dimensions throughout development..

Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart (2011)
Journal Article
Rutland, C. S., Polo-Parada, L., Ehler, E., Alibhai, A., Thorpe, A., Suren, S., …Loughna, S. (2011). Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart. Development, 138(18), https://doi.org/10.1242/dev.059063

The expression and function of embryonic myosin heavy chain (eMYH) has not been investigated within the early developing heart. This is despite the knowledge that other structural proteins, such as alpha and beta myosin heavy chains and cardiac alpha... Read More about Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart.

Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis (2009)
Journal Article
Rutland, C., Warner, L., Thorpe, A., Alibhai, A., Robinson, T., Shaw, B., …Loughna, S. (2009). Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis. Journal of Anatomy, 214(6), 905-915. https://doi.org/10.1111/j.1469-7580.2009.01079.x

Atrial septal defects are a common congenital heart defect in humans. Although mutations in different genes are now frequently being described, little is known about the processes and mechanisms behind the early stages of atrial septal development. B... Read More about Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis.