Genomic insights into cardiomyopathies: a comparative cross-species review

Simpson, Siobhan; Rutland, Paul; Rutland, Catrin S.

Abstract

n the global human population, the leading cause of non-communicable death is cardiovascular disease. It is predicted that by 2030, deaths attributable to cardiovascular disease will have risen to over 20 million per year. This review compares the cardiomyopathies in both human and non-human animals and identifies the genetic associations for each disorder in each species/taxonomic group. Despite differences between species, advances in human medicine can be gained by utilising animal models of cardiac disease; likewise, gains can be made in animal medicine from human genomic insights. Advances could include undertaking regular clinical checks in individuals susceptible to cardiomyopathy, genetic testing prior to breeding, and careful administration of breeding programmes (in non-human animals), further development of treatment regimes, and drugs and diagnostic techniques

Citation

Simpson, S., Rutland, P., & Rutland, C. S. (2017). Genomic insights into cardiomyopathies: a comparative cross-species review. Veterinary Sciences, 4(1), Article 19. https://doi.org/10.3390/vetsci4010019

• Journal Article Type: Article
• Acceptance Date: Mar 15, 2017
• Publication Date: Mar 21, 2017
• Deposit Date: Mar 22, 2017
• Publicly Available Date: Mar 22, 2017
• Journal: Veterinary Sciences
• Electronic ISSN: 2306-7381
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 1
• Article Number: 19
• DOI: https://doi.org/10.3390/vetsci4010019
• Public URL: https://nottingham-repository.worktribe.com/output/851497
• Publisher URL: http://www.mdpi.com/2306-7381/4/1/19
• Contract Date: Mar 22, 2017