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All Outputs (18)

Quantitative expression of oestrogen receptor in breast cancer: Clinical and molecular significance (2023)
Journal Article
Makhlouf, S., Quinn, C., Toss, M., Alsaleem, M., Atallah, N. M., Ibrahim, A., Rutland, C. S., Mongan, N. P., & Rakha, E. A. (2024). Quantitative expression of oestrogen receptor in breast cancer: Clinical and molecular significance. European Journal of Cancer, 197, Article 113473. https://doi.org/10.1016/j.ejca.2023.113473

Background

Oestrogen receptor (ER) positive breast cancer (BC) patients are eligible for endocrine therapy (ET), regardless of ER immunohistochemical expression level. There is a wide spectrum of ER expression and the response to ET is not uniform... Read More about Quantitative expression of oestrogen receptor in breast cancer: Clinical and molecular significance.

Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression (2023)
Journal Article
Atallah, N. M., Haque, M., Quinn, C., Toss, M. S., Makhlouf, S., Ibrahim, A., Green, A. R., Alsaleem, M., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. (2023). Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression. European Journal of Cancer, 195, Article 113371. https://doi.org/10.1016/j.ejca.2023.113371

Background: Breast cancer (BC) expressing low levels of human epidermal growth factor receptor 2 (HER2 Low) is an emerging category that needs further refining. This study aims to provide a comprehensive clinico-pathological and molecular profile of... Read More about Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression.

Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish (2023)
Journal Article
Emeish, W. F. A., Fawaz, M. M., Hussein, N. M., Al-Amgad, Z., Abd-ElHafeez, H. H., Rutland, C. S., & Bakry, K. A. (2023). Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish. Microscopy and Microanalysis, 29(5), 1774-1790. https://doi.org/10.1093/micmic/ozad091

Henneguya species are myxozoans, a suborder of Cnidaria, which can affect the gills and extrarespiratory organs of the African sharptooth catfish, Clarias gariepinus. This research describes natural infection-induced histological alterations caused b... Read More about Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish.

Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry (2023)
Journal Article
Alsafy, M. A., El-Gendy, S. A., Kamal, B. M., Rutland, C. S., Abd-Elhafeez, H. H., Soliman, S., ELKhamary, A. N., & Nomir, A. G. (2023). Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry. BMC Zoology, 8, Article 12. https://doi.org/10.1186/s40850-023-00173-w

Dromedary camel heart morphology is a crucial research topic with clinical applications. The study aims to understand the dromedary camel anatomy, morphology, and architecture of the ventricular mass. Results: Sagittal and transverse gross sections w... Read More about Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry.

Cardiovascular Stem Cell Applications in Experimental Animal Models (2023)
Book Chapter
Jeyapalan, J. N., Cockcroft, J., Rizvanov, A. A., Haider, K. H., & Rutland, C. S. (2023). Cardiovascular Stem Cell Applications in Experimental Animal Models. In K. H. Haider (Ed.), Cardiovascular Applications of Stem Cells (465-490). Springer Nature Singapore. https://doi.org/10.1007/978-981-99-0722-9_16

Stem cells are increasingly used in various species for differing diseases, most frequently experimentally. In addition, several animals are also used as models for both veterinary and human medicine. Differing stem cell types have been trialed with... Read More about Cardiovascular Stem Cell Applications in Experimental Animal Models.

Anatomical oropharyngeal cavity specialisations in the cutlassfish (Trichiurus lepturus, Linnaeus, 1758) (2023)
Journal Article
El-Bakary, N. E., Alsafy, M. A., Rutland, C. S., El-Gendy, S. A., & Kamal, B. M. (2023). Anatomical oropharyngeal cavity specialisations in the cutlassfish (Trichiurus lepturus, Linnaeus, 1758). Anatomia, Histologia, Embryologia, 52(6), 821-1033. https://doi.org/10.1111/ahe.12943

Trichiurus lepturus is a carnivorous fish, and most of the previous anatomical research has focused on computed tomography imaging and histology of their teeth and fangs, while the remaining structures of pharyngeal cavity remain unexplored. The pres... Read More about Anatomical oropharyngeal cavity specialisations in the cutlassfish (Trichiurus lepturus, Linnaeus, 1758).

Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus) (2023)
Journal Article
Abd-Elhafeez, H. H., Rutland, C. S., & Soliman, S. A. (2023). Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus). Microscopy Research and Technique, 86(9), 1108-1121. https://doi.org/10.1002/jemt.24374

Telocytes (TCs) are present in a broad range of species and regulate processes including homeostasis, tissue regeneration and immunosurveillance. This novel study describes the morphological features of migrating TCs and their role during cartilage d... Read More about Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus).

Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus) (2023)
Preprint / Working Paper
Abd‐Elhafeez, H. H., Rutland, C. S., & Soliman, S. Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus)

Telocytes (TCs) are present in a broad range of species and regulate processes including homeostasis, tissue regeneration and immunosurveillance. This novel study describes the morphological features of migrating TCs and their role during cartilage d... Read More about Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus).

Encapsulated papillary carcinoma of the breast: does it have a native basement membrane? (2023)
Preprint / Working Paper
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. A. (2023). Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?

Background Encapsulated papillary carcinoma (EPC) is surrounded by a thick fibrous capsule‐like structure, which is interpreted as a thickened basement membrane (BM). This study aimed to describe the geometric characteristics of the EPC capsule and t... Read More about Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?.

Encapsulated papillary carcinoma of the breast: does it have a native basement membrane? (2023)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. (2023). Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?. Histopathology, 83(3), 376-393. https://doi.org/10.1111/his.14939

Background
Encapsulated papillary carcinoma (EPC) is surrounded by a thick fibrous capsule-like structure, which is interpreted as a thickened basement membrane (BM). This study aimed to describe the geometric characteristics of the EPC capsule and... Read More about Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?.

Topographic anatomy and vascularization of the glandula thyroidea in rats (2023)
Journal Article
Nur, I. H., Pérez, W., & Rutland, C. S. (2023). Topographic anatomy and vascularization of the glandula thyroidea in rats. Anatomia, Histologia, Embryologia, 52(4), 571-582. https://doi.org/10.1111/ahe.12916

Topographical anatomy and detailed measurements of the glandula thyroidea (thyroid gland) and the glandula parathyroidea (parathyroid gland) were determined in rats, with significant differences identified between the sexes. In the rats (N=10 male, 1... Read More about Topographic anatomy and vascularization of the glandula thyroidea in rats.

Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports (2023)
Preprint / Working Paper
Kovac, M., Aliev, R., Berestov, I., Aimaletdinov, A., Rutland, C., Rizvanov, A., & Zakirova, E. Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports

Injury to the proximal part of the equine suspensory ligament (SL), called proximal suspensory desmitis (PSD), commonly causes lameness in horses. PSD is extremely difficult to manage and treat, with present methods often unable to achieve full recov... Read More about Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports.

The Relationship of Sperm Motility Pattern and Its Ability to Agglutinate with Vaginal Sperm Selection, Uptake in Sperm Storage Tubules and Competitiveness (2023)
Book Chapter
Sayed, M. A. M., Abd Elhafeez, H. H., Rutland, C. S., & El-Sherry, T. M. (2023). The Relationship of Sperm Motility Pattern and Its Ability to Agglutinate with Vaginal Sperm Selection, Uptake in Sperm Storage Tubules and Competitiveness. In G. Téllez-Isaías (Ed.), Poultry Farming - New Perspectives and Applications [Working Title]. InTech. https://doi.org/10.5772/intechopen.110198

To ensure survival, some unique features can be distinguished in birds that help them maintain reproduction. These features include the ability to store sperm for long periods within the utero-vaginal junction, a high sperm concentration per ejaculat... Read More about The Relationship of Sperm Motility Pattern and Its Ability to Agglutinate with Vaginal Sperm Selection, Uptake in Sperm Storage Tubules and Competitiveness.

The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode (2023)
Journal Article
Baron, F., Zhang, M., Archer, N., Bellows, E., Knight, H. M., Welham, S., Rutland, C. S., Mongan, N. P., Hayes, C. J., Fray, R. G., & Bodi, Z. (2023). The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode. RNA, 29(6), 777-789. https://doi.org/10.1261/rna.079615.123

N6-methyladenosine (m6A) in mRNA regulates almost every stage in the mRNA life cycle, and the development of methodologies for the high-throughput detection of methylated sites in mRNA using m6A-specific methylated RNA immunoprecipitation with next-g... Read More about The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode.

Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells (2023)
Journal Article
Soliman, S. A., Abd-Elhafeez, H. H., Mohamed, N.-E., Al-Rashdi, B. M., Alghamdi, A. A., Elmansi, A., Salah, A. S., El-Gendy, S. A., Rutland, C. S., & Massoud, D. (2023). Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells. Microscopy Research and Technique, 86(5), 600-613. https://doi.org/10.1002/jemt.24298

Varanus niloticus is a lizard residing within the Varanidae family. To date no studies detailing its blood morphology and characteristics have been conducted. This study used histologically stained blood and bone marrow samples to visualize the cells... Read More about Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells.

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer (2023)
Journal Article
Lothion-Roy, J., Haigh, D. B., Harris, A. E., Metzler, V. M., Alsaleem, M., Toss, M. S., Kariri, Y., Ntekim, A., Robinson, B. D., Khani, F., Gudas, L. J., Allegrucci, C., James, V. H., Madhusudan, S., Mather, M., Emes, R. D., Archer, N., Fray, R. G., Rakha, E., Jeyapalan, J. N., …Woodcock, C. L. (2023). Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Frontiers in Genetics, 13, Article 1096071. https://doi.org/10.3389/fgene.2022.1096071

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are... Read More about Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer (2023)
Journal Article
Metzler, V. M., de Brot, S., Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., Nilsson, E. M., Ntekim, A., Persson, J. L., Robinson, B. D., Khani, F., Laursen, K. B., Gudas, L. J., Toss, M. S., Madhusudan, S., Rakha, E., Heery, D. M., Rutland, C. S., Mongan, N. P., & Jeyapalan, J. N. (2023). The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Frontiers in Cell and Developmental Biology, 11, Article 1116424. https://doi.org/10.3389/fcell.2023.1116424

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types... Read More about The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.