All Outputs (5)

The role of mesenchymal cells in cholangiocarcinoma (2024)
Journal Article
Sueca-Comes, M., Rusu, E. C., Ashworth, J. C., Collier, P., Probert, C., Ritchie, A., Meakin, M., Mongan, N. P., Egbuniwe, I. U., Andersen, J. B., Bates, D. O., & Grabowska, A. M. (2024). The role of mesenchymal cells in cholangiocarcinoma. Disease Models and Mechanisms, 17(12), Article dmm050716. https://doi.org/10.1242/dmm.050716

The tumour microenvironment (TME) significantly influences tumour formation and progression through dynamic interactions. Cholangiocarcinoma (CCA), a highly desmoplastic tumour, lacks early diagnostic biomarkers and has limited effective treatments o... Read More about The role of mesenchymal cells in cholangiocarcinoma.

Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study (2024)
Journal Article
Vijay, A., Kelly, A., Miller, S., Marshall, M., Alonso, A., Kouraki, A., Probert, C., Simpson, E. J., & Valdes, A. M. (2024). Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study. Nutrients, 16(19), 3326. https://doi.org/10.3390/nu16193326

Background/Objective: Although low-methoxy (LM) pectin (polysaccharides extracted from citrus peels) can reduce inflammation by binding to and inhibiting the TLR-2 pathway in animal models and in vitro studies, the anti-inflammatory effects of LM pec... Read More about Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study.

Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts (2023)
Journal Article
Jones, S., Ashworth, J. C., Meakin, M., Collier, P., Probert, C., Ritchie, A. A., Merry, C. L. R., & Grabowska, A. M. (2023). Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts. In Vitro Models, 2(3-4), 99-111. https://doi.org/10.1007/s44164-023-00048-x

Purpose
This 3D in vitro cancer model for propagation of patient-derived cells, using a synthetic self-assembling peptide gel, allows the formation of a fully characterised, tailorable tumour microenvironment. Unlike many existing 3D cancer models,... Read More about Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts.

A 3D Heterotypic Breast Cancer Model Demonstrates a Role for Mesenchymal Stem Cells in Driving a Proliferative and Invasive Phenotype (2020)
Journal Article
Pal, A., Ashworth, J. C., Collier, P., Probert, C., Jones, S., Leza, E. P., Meakin, M. L., A. Ritchie, A., Onion, D., Clarke, P. A., Allegrucci, C., & Grabowska, A. M. (2020). A 3D Heterotypic Breast Cancer Model Demonstrates a Role for Mesenchymal Stem Cells in Driving a Proliferative and Invasive Phenotype. Cancers, 12(8), Article 2290. https://doi.org/10.3390/cancers12082290

Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis (2018)
Journal Article
Probert, C., Dottorini, T., Speakman, A., Hunt, S., Nafee, T., Fazeli, A., Wood, S., Brown, J. E., & James, V. (2019). Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis. Oncogene, 38(10), 1751-1763. https://doi.org/10.1038/s41388-018-0540-5

© 2018, The Author(s). The role of extracellular vesicles (EVs) as vehicles for cell-to-cell communication between a tumour and its environment is a relatively new concept. The hypothesis that EVs may be critical in co-opting tissues by tumours to ge... Read More about Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis.