All Outputs (7)

SLC1A5 co-expression with TALDO1 associates with endocrine therapy failure in estrogen receptor-positive breast cancer (2021)
Journal Article
Alfarsi, L. H., Ansari, R. E., Craze, M. L., Mohammed, O. J., Masisi, B. K., Ellis, I. O., …Green, A. R. (2021). SLC1A5 co-expression with TALDO1 associates with endocrine therapy failure in estrogen receptor-positive breast cancer. Breast Cancer Research and Treatment, 189(2), 317-331. https://doi.org/10.1007/s10549-021-06298-1

Purpose: Identification of effective biomarkers for the benefit of endocrine treatment and understanding the molecular pathways that contribute to the development of resistance are of crucial importance to the management of luminal breast cancer. The... Read More about SLC1A5 co-expression with TALDO1 associates with endocrine therapy failure in estrogen receptor-positive breast cancer.

PP1, PKA and DARPP-32 in breast cancer: a retrospective assessment of protein and mRNA expression (2021)
Journal Article
Saidy, B., Kotecha, S., Butler, A., Rakha, E., Ellis, I., Green, A., …Storr, S. (2021). PP1, PKA and DARPP-32 in breast cancer: a retrospective assessment of protein and mRNA expression. Journal of Cellular and Molecular Medicine, 25(11), 5015-5024. https://doi.org/10.1111/jcmm.16447

Cyclic-AMP dependent protein kinase A (PKA) and protein phosphatase 1 (PP1) are proteins involved in numerous essential signalling pathways that modulate physiological and pathological functions. Both PP1 and PKA can be inhibited by dopamine and cAMP... Read More about PP1, PKA and DARPP-32 in breast cancer: a retrospective assessment of protein and mRNA expression.

RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer (2021)
Journal Article
Sanz-Moreno, A., Palomeras, S., Pedersen, K., Morancho, B., Pascual, T., Galván, P., …Gonzalez-Suarez, E. (2021). RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer. Breast Cancer Research, 23(1), Article 42. https://doi.org/10.1186/s13058-021-01390-2

Background Around 15–20% of primary breast cancers are characterized by HER2 protein overexpression and/or HER2 gene amplification. Despite the successful development of anti-HER2 drugs, intrinsic and acquired resistance represents a major hurdle. T... Read More about RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer.

Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells (2021)
Journal Article
Lu, X., Redon, C. E., Tang, W., Parvathaneni, S., Bokhari, B., Debnath, S., …Sharma, S. (2021). Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells. Molecular and Cellular Biology, 41(4), e00515-20. https://doi.org/10.1128/mcb.00515-20

Susceptibility to breast cancer is significantly increased in individuals with germ line mutations in RECQ1 (also known as RECQL or RECQL1), a gene encoding a DNA helicase essential for genome maintenance. We previously reported that RECQ1 expression... Read More about Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells.

Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies (2021)
Journal Article
Sneha, S., Baker, S. C., Green, A., Storr, S., Aiyappa, R., Martin, S., & Pors, K. (2021). Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies. Biomedicines, 9(3), Article 290. https://doi.org/10.3390/biomedicines9030290

Age-related biology of early-stage operable breast cancer and its impact on clinical outcome (2021)
Journal Article
Cheung, K. L., Ellis, I. O., Morgan, D. A., Rakha, E. A., Green, A. R., & Syed, B. M. (2021). Age-related biology of early-stage operable breast cancer and its impact on clinical outcome. Cancers, 13(6), Article 1417. https://doi.org/10.3390/cancers13061417

As age advances, breast cancer (BC) tends to change its biological characteristics. This study aimed to explore the natural progression of such changes. The study included 2383 women with clinically T0-2N0-1M0 BC, managed by primary surgery and optim... Read More about Age-related biology of early-stage operable breast cancer and its impact on clinical outcome.

The role of ALDH1A1 in contributing to breast tumour aggressiveness: A study conducted in an African population (2021)
Journal Article
Gyan, E., Green, A., Ahenkorah-Fondjo, L., Jackson, A., Toss, M. S., Akakpo, P. K., …Owiredu, W. (2021). The role of ALDH1A1 in contributing to breast tumour aggressiveness: A study conducted in an African population. Annals of Diagnostic Pathology, 51, Article 151696. https://doi.org/10.1016/j.anndiagpath.2020.151696

Aldehyde dehydrogenase 1 member A1 (ALDH1A1) is one of the most well studied breast cancer stem cells. Its expression has been associated with poor clinicopathological features and clinical outcomes in several studies. This paper studies the expressi... Read More about The role of ALDH1A1 in contributing to breast tumour aggressiveness: A study conducted in an African population.