All Outputs (97)

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels (2018)
Journal Article
Jiang, X., O’Reilly, P. F., Aschard, H., Hsu, Y.-H., Richards, J. B., Dupuis, J., …Kiel, D. P. (2018). Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nature Communications, 9(1), Article 260. https://doi.org/10.1038/s41467-017-02662-2

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). I... Read More about Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study (2017)
Journal Article
Abhishek, A., Valdes, A. M., Jenkins, W., Zhang, W., & Doherty, M. (2017). Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study. PLoS ONE, 12(10), Article e0186096. https://doi.org/10.1371/journal.pone.0186096

Objectives To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute... Read More about Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study.

Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans (2017)
Journal Article
Valdes, A. M., Ravipati, S., Menni, C., Abhishek, A., Metrustry, S., Harris, J., …Barrett, D. A. (in press). Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans. Scientific Reports, 7, Article 10748. https://doi.org/10.1038/s41598-017-09516-3

Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models... Read More about Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand (2017)
Journal Article
Hollander, W. D., Boer, C. G., Hart, D. J., Yau, M. S., Ramos, Y. F., Metrustry, S., …van Meurs, J. J. (2017). Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2017-211214

Objective Osteoarthritis (OA) is the most common form of arthritis and the leading cause of disability in the elderly. Of all the joints, genetic predisposition is strongest for OA of the hand; however, only few genetic risk loci for hand OA have bee... Read More about Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.

Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis (2017)
Journal Article
Valdes, A. M., Abhishek, A., Muir, K., Zhang, W., Maciewicz, R. A., & Doherty, M. (2017). Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis. Arthritis Care and Research, 69(7), 1076-1081. https://doi.org/10.1002/acr.23091

Objective: Recent findings suggest that β-adrenergic blockers have anti-nociceptive properties. The aim of this study was to compare levels of large joint pain between those on adrenergic blockers and those on other antihypertensive medications. Met... Read More about Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis.

Gut microbiome diversity and high-fibre intake are related to lower long-term weight gain (2017)
Journal Article

BACKGROUND: Cross-sectional studies suggest that the microbes in the human gut have a role in obesity by influencing the human body’s ability to extract and store calories. The aim of this study was to assess if there is a correlation between change... Read More about Gut microbiome diversity and high-fibre intake are related to lower long-term weight gain.

Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study (2017)
Journal Article

© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. Objective. The aim was to estimate familial relative risk (RR) for RA and other autoimmune diseases and the genetic contri... Read More about Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study.

Mitochondrial DNA haplogroups and ageing mechanisms in osteoarthritis (2017)
Journal Article
Valdes, A. M., & Goldring, M. B. (in press). Mitochondrial DNA haplogroups and ageing mechanisms in osteoarthritis. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2016-210783

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study (2016)
Journal Article

Background C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. Methods and Findings We performed Mendelian randomization (MR)... Read More about Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.

A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population (2015)
Journal Article

Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Valdes, A. M., See, L.-C., Luo, S.-F., Yu, K.-H., …Doherty, M. (2015). Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families. JAMA Internal Medicine, 175(9), 1518-1526. https://doi.org/10.1001/jamainternmed.2015.3528

IMPORTANCE: Relatives of patients with systemic lupus erythematosus (SLE) appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable. Furthermore, relative contri... Read More about Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families.

Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Valdes, A. M., See, L.-C., Luo, S.-F., Yu, K.-H., …Doherty, M. (2015). Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study. Arthritis and Rheumatology, 67(7), 1904-1912. https://doi.org/10.1002/art.39127

Objective: To investigate familial aggregation of Sjögren's syndrome (SS) and the relative risks (RRs) of other autoimmune disease in relatives of patients with SS. Methods: We identified 23,658,577 beneficiaries enrolled in the Taiwan National Hea... Read More about Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study.

Circulating levels of antioxidant vitamins correlate with better lung function and reduced exposure to ambient pollution (2015)
Journal Article

An atlas of genetic influences on human blood metabolites (2014)
Journal Article

Genome-wide association scans with high-throughput metabolic profiling provide unprecedented insights into how genetic variation influences metabolism and complex disease. Here we report the most comprehensive exploration of genetic loci influencing... Read More about An atlas of genetic influences on human blood metabolites.

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31 (2014)
Journal Article

Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan (2013)
Journal Article
Kuo, C., Grainge, M. J., See, L., Yu, K., Luo, S., Valdes, A. M., …Doherty, M. (2015). Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan. Annals of the Rheumatic Diseases, 74(2), 369-374. https://doi.org/10.1136/annrheumdis-2013-204067

© 2015, BMJ Publishing Group. All rights reserved. Objective: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population. Methods: Using data from the Nati... Read More about Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan.

The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study (2013)
Journal Article

© 2015, BMJ Publishing Group. All rights reserved. Objective: Variation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA). We e... Read More about The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study.