All Outputs (11)

Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes (2021)
Journal Article
Ghosh, M., Majkowska, A., Mirsa, R., Bera, S., Rodríguez-Cabello, J. C., Mata, A., & Adler-Abramovich, L. (2022). Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes. ACS Applied Materials and Interfaces, 14(1), 464-473. https://doi.org/10.1021/acsami.1c22136

Molecular self-assembly is a spontaneous natural process resulting in highly ordered nano to microarchitectures. We report temperature-independent formation of robust stable membranes obtained by the spontaneous interaction of intrinsically disordere... Read More about Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes.

Peptide Amphiphile Hydrogels Based on Homoternary Cucurbit[8]uril Host-Guest Complexes (2021)
Journal Article
Redondo-Gómez, C., Padilla-Lopátegui, S., Mata, A., & Azevedo, H. S. (2022). Peptide Amphiphile Hydrogels Based on Homoternary Cucurbit[8]uril Host-Guest Complexes. Bioconjugate Chemistry, 33(1), 111-120. https://doi.org/10.1021/acs.bioconjchem.1c00441

Supramolecular hydrogels based on peptide amphiphiles (PAs) are promising materials for tissue engineering and model extracellular matrixes for biological studies. While PA hydrogels are conventionally formed via electrostatic screening, new hydrogel... Read More about Peptide Amphiphile Hydrogels Based on Homoternary Cucurbit[8]uril Host-Guest Complexes.

Exploiting the fundamentals of biological organization for the advancement of biofabrication (2021)
Journal Article
Hill, J., Wildman, R., & Mata, A. (2022). Exploiting the fundamentals of biological organization for the advancement of biofabrication. Current Opinion in Biotechnology, 74, 42-54. https://doi.org/10.1016/j.copbio.2021.10.016

The field of biofabrication continues to progress, offering higher levels of spatial control, reproducibility, and functionality. However, we remain far from recapitulating what nature has achieved. Biological systems such as tissues and organs are a... Read More about Exploiting the fundamentals of biological organization for the advancement of biofabrication.

Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology (2021)
Journal Article
Osuna de la Peña, D., Trabulo, S. M. D., Collin, E., Liu, Y., Sharma, S., Tatari, M., …Loessner, D. (2021). Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology. Nature Communications, 12, Article 5623. https://doi.org/10.1038/s41467-021-25921-9

Patient-derived in vivo models of human cancer have become a reality, yet their turnaround time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully recapitulate in vivo tumour biology are urgently needed. These... Read More about Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology.

Polymyxin B‐Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy (2021)
Journal Article
Shi, Y., Wareham, D. W., Yuan, Y., Deng, X., Mata, A., & Azevedo, H. S. (2021). Polymyxin B‐Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy. Advanced Healthcare Materials, 10(22), Article 2101465. https://doi.org/10.1002/adhm.202101465

Repurposing old antibiotics into more effective and safer formulations is an emergent approach to tackle the growing threat of antimicrobial resistance. Herein, a peptide hydrogel is reported for the localized and sustained release of polymyxin B (PM... Read More about Polymyxin B‐Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy.

Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing (2021)
Journal Article
Ajovalasit, A., Redondo-Gómez, C., Sabatino, M. A., Okesola, B. O., Braun, K., Mata, A., & Dispenza, C. (2021). Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing. Regenerative Biomaterials, 8(5), Article rbab040. https://doi.org/10.1093/rb/rbab040

Hydrogel wound dressings can play critical roles in wound healing protecting the wound from trauma or contamination and providing an ideal environment to support the growth of endogenous cells and promote wound closure. This work presents a self-asse... Read More about Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing.

De Novo Design of Functional Co-Assembling Organic-Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization (2021)
Journal Article
Okesola, B. O., Mendoza-Martinez, A. K., Cidonio, G., Derkus, B., Boccorh, D. K., Osuna de la Peña, D., …Mata, A. (2021). De Novo Design of Functional Co-Assembling Organic-Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization. ACS Nano, 15(7), 11202–11217. https://doi.org/10.1021/acsnano.0c09814

Synthetic nanostructured materials incorporating both organic and inorganic components offer a unique, powerful and versatile class of materials for widespread applications due to the distinct, yet complementary, nature of the intrinsic properties of... Read More about De Novo Design of Functional Co-Assembling Organic-Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization.

Topographically guided hierarchical mineralization (2021)
Journal Article
Deng, X., Hasan, A., Elsharkawy, S., Tejeda-Montes, E., Tarakina, N. V., Greco, G., …Mata, A. (2021). Topographically guided hierarchical mineralization. Materials Today Bio, 11, Article 100119. https://doi.org/10.1016/j.mtbio.2021.100119

Material platforms based on interaction between organic and inorganic phases offer enormous potential to develop materials that can recreate the structural and functional properties of biological systems. However, the capability of organic-mediated m... Read More about Topographically guided hierarchical mineralization.

Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding (2021)
Journal Article
Radvar, E., Griffanti, G., Tsolaki, E., Bertazzo, S., Nazhat, S. N., Addison, O., …Elsharkawy, S. (2021). Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding. Advanced NanoBiomed Research, 1(8), Article 2100042. https://doi.org/10.1002/anbr.202100042

Physiological calcification plays an essential part in the development of the skeleton and teeth; however, the occurrence of calcification in soft tissues such as the brain, heart, and kidneys associates with health impacts, creating a massive social... Read More about Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding.

An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability (2021)
Journal Article
Wu, Y., Fortunato, G. M., Okesola, B. O., Pellerej Di Brocchetti, F. L., Suntornnond, R., Connelly, J., …Et Al, W. (2021). An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability. Biofabrication, 13(3), Article 035027. https://doi.org/10.1088/1758-5090/abe4c3

Self-assembling bioinks offer the possibility to biofabricate with molecular precision, hierarchical control, and biofunctionality. For this to become a reality with widespread impact, it is essential to engineer these ink systems ensuring reproducib... Read More about An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability.

Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model (2021)
Journal Article
Sennett, M., Friedman, J., Ashley, B., Stoeckl, B., Patel, J., Alini, M., …Dodge, G. (2021). Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model. eCells and Materials Journal, 41, 40-51. https://doi.org/10.22203/ecm.v041a04

The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics. Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis. Current repair technique... Read More about Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.