Seizure outcomes in people with drug-resistant focal epilepsy evaluated for surgery but do not proceed

Khoo, Anthony; de Tisi, Jane; Mannan, Shahidul; O’Keeffe, Aidan G.; Sander, Josemir W.; Duncan, John S.

doi:10.1016/j.eplepsyres.2021.106822

Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning (2025)
Journal Article
Dasgupta, D., Elliott, C. A., O’Keeffe, A. G., Rodionov, R., Li, K., Vakharia, V. N., Mirza, F. A., Tahir, M. Z., Tisdall, M. M., Miserocchi, A., McEvoy, A. W., Ourselin, S., Sparks, R. E., & Duncan, J. S. (2025). Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning. Frontiers in Neurology, 16, Article 1514442. https://doi.org/10.3389/fneur.2025.1514442

Objectives: This study aims to refine computer-assisted planning (CAP) of SEEG implantations by adding spatial constraints from prior SEEG trajectories (“Priors”) to improve safety and reduce manual adjustments, without increasing planning time. Meth... Read More about Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning.

Evaluating a model of best practice in primary care led post-diagnostic dementia care: feasibility and acceptability findings from the PriDem study (2024)
Journal Article
Griffiths, S., Spencer, E., Flanagan, K., O'Keeffe, A., Hunter, R., Wiegand, M., D'Andrea, F., Benjamin, L., Poole, M., Hagan, A. J., Brar, M., Wilcock, J., Walters, K. R., Robinson, L., & Rait, G. (2024). Evaluating a model of best practice in primary care led post-diagnostic dementia care: feasibility and acceptability findings from the PriDem study. BMJ Open, 14(7), Article e083175. https://doi.org/10.1136/bmjopen-2023-083175

Objectives: To evaluate the feasibility and acceptability of a primary care-based intervention for improving post-diagnostic dementia care and support (PriDem), and implementation study procedures. Design: A non-randomised, mixed methods, feasibility... Read More about Evaluating a model of best practice in primary care led post-diagnostic dementia care: feasibility and acceptability findings from the PriDem study.

Access to personalised dementia care planning in primary care: a mixed methods evaluation of the PriDem intervention (2024)
Journal Article
Spencer, E., Griffiths, S., Flanagan, K., O'Keeffe, A., Wiegand, M., Benjamin, L., D'Andrea, F., Wilcock, J., Poole, M., Walters, K. R., Robinson, L., & Rait, G. (2024). Access to personalised dementia care planning in primary care: a mixed methods evaluation of the PriDem intervention. BMJ Open, 14(7), Article e082083. https://doi.org/10.1136/bmjopen-2023-082083

Objectives: Provision of personalised care planning is a national priority for people with dementia. Research suggests a lack of quality and consistency of care plans and reviews. The PriDem model of care was developed to deliver feasible and accepta... Read More about Access to personalised dementia care planning in primary care: a mixed methods evaluation of the PriDem intervention.

Approaches to risk ratio estimation in a regression discontinuity design: Application to the prescription of statins for cholesterol reduction in UK primary care (2023)
Journal Article
Adeleke, M. O., O’Keeffe, A. G., & Baio, G. (2023). Approaches to risk ratio estimation in a regression discontinuity design: Application to the prescription of statins for cholesterol reduction in UK primary care. Statistical Methods in Medical Research, 32(10), 1994-2015. https://doi.org/10.1177/09622802231192958

In recent years regression discontinuity designs have been used increasingly for the estimation of treatment effects in observational medical data where a rule-based decision to apply treatment is taken using a continuous assignment variable. Most re... Read More about Approaches to risk ratio estimation in a regression discontinuity design: Application to the prescription of statins for cholesterol reduction in UK primary care.

Protocol for the feasibility and implementation study of a model of best practice in primary care led postdiagnostic dementia care: PriDem. (2023)
Journal Article
Griffiths, S., Spencer, E., Wilcock, J., Bamford, C., Wheatley, A., Brunskill, G., D'Andrea, F., Walters, K. R., Lago, N., O'Keeffe, A., Hunter, R., Tuijt, R., Harrison Dening, K., Banerjee, S., Manthorpe, J., Allan, L., Robinson, L., & Rait, G. (2023). Protocol for the feasibility and implementation study of a model of best practice in primary care led postdiagnostic dementia care: PriDem. BMJ Open, 13(8), Article e070868. https://doi.org/10.1136/bmjopen-2022-070868

Introduction: Care is often inadequate and poorly integrated after a dementia diagnosis. Research and policy highlight the unaffordability and unsustainability of specialist-led support, and instead suggest a task-shared model, led by primary care. T... Read More about Protocol for the feasibility and implementation study of a model of best practice in primary care led postdiagnostic dementia care: PriDem..

The impact of temporal lobe epilepsy surgery on picture naming and its relationship to network metric change. (2023)
Journal Article
Peter Binding, L., Neal Taylor, P., O'Keeffe, A. G., Giampiccolo, D., Fleury, M., Xiao, F., Caciagli, L., de Tisi, J., Winston, G. P., Miserocchi, A., McEvoy, A., Duncan, J. S., & Vos, S. B. (2023). The impact of temporal lobe epilepsy surgery on picture naming and its relationship to network metric change. NeuroImage: Clinical, 38, Article 103444. https://doi.org/10.1016/j.nicl.2023.103444

Background: Anterior temporal lobe resection (ATLR) is a successful treatment for medically-refractory temporal lobe epilepsy (TLE). In the language-dominant hemisphere, 30%- 50% of individuals experience a naming decline which can impact upon daily... Read More about The impact of temporal lobe epilepsy surgery on picture naming and its relationship to network metric change..

Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy (2023)
Journal Article
Binding, L. P., Dasgupta, D., Taylor, P. N., Thompson, P. J., O'Keeffe, A. G., De Tisi, J., Mcevoy, A. W., Miserocchi, A., Duncan, J. S., Duncan, J. S., & Vos, S. B. (2023). Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy. Neurology, 100(15), e1621-e1633. https://doi.org/10.1212/WNL.0000000000206862

Background and ObjectivesIn medically refractory temporal lobe epilepsy (TLE), 30%-50% of patients experience substantial language decline after resection in the language-dominant hemisphere. In this study, we investigated the contribution of white m... Read More about Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy.

Hippocampal resection in temporal lobe epilepsy: Do we need to resect the tail? (2023)
Journal Article
Dasgupta, D., Finn, R., Chari, A., Giampiccolo, D., de Tisi, J., O’Keeffe, A. G., Miserocchi, A., McEvoy, A. W., Vos, S. B., & Duncan, J. S. (2023). Hippocampal resection in temporal lobe epilepsy: Do we need to resect the tail?. Epilepsy Research, 190, Article 107086. https://doi.org/10.1016/j.eplepsyres.2023.107086

Introduction: Anteromesial temporal lobe resection is the most common surgical technique used to treat drug-resistant mesial temporal lobe epilepsy, particularly when secondary to hippocampal sclerosis. Structural and functional imaging data suggest... Read More about Hippocampal resection in temporal lobe epilepsy: Do we need to resect the tail?.

Long-term seizure, psychiatric and socioeconomic outcomes after frontal lobe epilepsy surgery (2022)
Journal Article
Khoo, A., de Tisi, J., Foong, J., Bindman, D., O'Keeffe, A. G., Sander, J. W., Miserocchi, A., McEvoy, A. W., & Duncan, J. S. (2022). Long-term seizure, psychiatric and socioeconomic outcomes after frontal lobe epilepsy surgery. Epilepsy Research, 186, Article 106998. https://doi.org/10.1016/j.eplepsyres.2022.106998

Objective: Resective surgery for selected individuals with frontal lobe epilepsy can be effective, although multimodal outcomes are less established than in temporal lobe epilepsy. We describe long-term seizure remission and relapse patterns, psychia... Read More about Long-term seizure, psychiatric and socioeconomic outcomes after frontal lobe epilepsy surgery.

Zibotentan in systemic sclerosis-associated chronic kidney disease: a phase II randomised placebo-controlled trial (2022)
Journal Article
Stern, E. P., Host, L. V., Wanjiku, I., Escott, J., Gilmour, P. S., Ochiel, R., Unwin, R., Burns, A., Ong, V. H., Cadiou, H., O'Keeffe, A. G., & Denton, C. P. (2022). Zibotentan in systemic sclerosis-associated chronic kidney disease: a phase II randomised placebo-controlled trial. Arthritis Research and Therapy, 24(1), Article 130. https://doi.org/10.1186/s13075-022-02818-6

Background We report results from a phase II randomised placebo-controlled trial assessing zibotentan, a highly selective endothelin receptor antagonist (ERA), in chronic kidney disease (CKD) secondary to systemic sclerosis (SSc).

Methods This t... Read More about Zibotentan in systemic sclerosis-associated chronic kidney disease: a phase II randomised placebo-controlled trial.

Regression discontinuity designs for time-to-event outcomes: An approach using accelerated failure time models (2022)
Journal Article
Adeleke, M. O., Baio, G., & O'Keeffe, A. G. (2022). Regression discontinuity designs for time-to-event outcomes: An approach using accelerated failure time models. Journal of the Royal Statistical Society: Series A, 185(3), 1216-1246. https://doi.org/10.1111/rssa.12812

Regression discontinuity designs (RDDs) have been developed for the estimation of treatment effects using observational data, where a treatment is administered using an externally defined decision rule, linked to a continuous assignment variable. Typ... Read More about Regression discontinuity designs for time-to-event outcomes: An approach using accelerated failure time models.

Cost of pre-surgical evaluation for epilepsy surgery: A single-center experience (2022)
Journal Article
Khoo, A., Martin, L., de Tisi, J., O’Keeffe, A. G., Sander, J. W., & Duncan, J. S. (2022). Cost of pre-surgical evaluation for epilepsy surgery: A single-center experience. Epilepsy Research, 182, Article 106910. https://doi.org/10.1016/j.eplepsyres.2022.106910

Objective: To estimate the cost and time taken to evaluate adults with drug-resistant focal epilepsy for potentially curative surgery. Methods: We reviewed data on 100 consecutive individuals at a tertiary referral center evaluated for epilepsy surge... Read More about Cost of pre-surgical evaluation for epilepsy surgery: A single-center experience.

Seizure outcomes in people with drug-resistant focal epilepsy evaluated for surgery but do not proceed (2021)
Journal Article
Khoo, A., de Tisi, J., Mannan, S., O’Keeffe, A. G., Sander, J. W., & Duncan, J. S. (2021). Seizure outcomes in people with drug-resistant focal epilepsy evaluated for surgery but do not proceed. Epilepsy Research, 178, Article 106822. https://doi.org/10.1016/j.eplepsyres.2021.106822

Objective: To ascertain seizure outcomes in people with drug-resistant focal epilepsy considered for epilepsy surgery but who did not proceed. Methods: We identified people discussed at a weekly presurgical epilepsy multi-disciplinary (MDT) meeting f... Read More about Seizure outcomes in people with drug-resistant focal epilepsy evaluated for surgery but do not proceed.

All Outputs (13)