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Regression discontinuity designs for time-to-event outcomes: An approach using accelerated failure time models

Adeleke, Mariam O; Baio, Gianluca; O'Keeffe, Aidan G

Authors

Mariam O Adeleke

Gianluca Baio



Abstract

Regression discontinuity designs (RDDs) have been developed for the estimation of treatment effects using observational data, where a treatment is administered using an externally defined decision rule, linked to a continuous assignment variable. Typically, RDDs have been applied to situations where the outcome of interest is continuous and non-temporal. Conversely, RDDs for time-to-event outcomes have received less attention , despite such outcomes being common in many applications. We explore RDDs for a time-to-event outcome subject to right censoring. An accelerated failure time approach is used to establish a treatment effect estimate for a fuzzy RDD (where treatment is not always strictly applied according to the decision rule). This estimation approach is robust to different levels of fuzziness and unobserved confounding, assessed using simulation studies and compares favourably to established structural accelerated failure time models. A motivating example is presented in which models are fitted to estimate the effect of met-formin on mortality and cardiovascular disease rate using real observational data from UK Primary Care.

Citation

Adeleke, M. O., Baio, G., & O'Keeffe, A. G. (in press). Regression discontinuity designs for time-to-event outcomes: An approach using accelerated failure time models. Journal of the Royal Statistical Society: Series A,

Journal Article Type Article
Acceptance Date Jan 4, 2022
Deposit Date Jan 14, 2022
Journal Journal of the Royal Statistical Society: Series A
Print ISSN 0964-1998
Publisher Wiley
Peer Reviewed Peer Reviewed
Public URL https://nottingham-repository.worktribe.com/output/7228784

This file is under embargo due to copyright reasons.




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