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Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II) (2019)
Journal Article
Chinchilla, S. P., Doherty, M., & Abhishek, A. (2019). Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II). Rheumatology,

Objectives: To examine the predictive validity of the Gout Activity Score (GAS), its’ correlation with the Gout Impact Scale (GIS), and their sensitivity to change. Methods: Data from a clinical trial in which participants with ≥1 gout flare in th... Read More

Implication of nurse intervention on engagement with urate-lowering drugs: a qualitative study of participants in a RCT of nurse led care (2018)
Journal Article
Latif, Z. P., Nakafero, G., Jenkins, W., Doherty, M., & Abhishek, A. (2018). Implication of nurse intervention on engagement with urate-lowering drugs: a qualitative study of participants in a RCT of nurse led care. Joint Bone Spine, doi:10.1016/j.jbspin.2018.10.008

Objectives To explore patient perception of the role of a nurse-led complex package of care in facilitating engagement with urate-lowering therapies (ULTs) in the management of gout. Methods Thirty people who had participated in a randomised control... Read More

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis (2018)
Journal Article
Valdes, A. M., Ravipati, S., Pousinis, P., Menni, C., Mangino, M., Abhishek, A., …Doherty, M. (in press). Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis. Journal of Lipid Research, 59(7), doi:10.1194/jlr.P085118. ISSN 0022-2275

Omega-6 fatty acids are important inflammatory mediators increased in joints with osteoarthritis (OA) joints. To investigate the relationship between omega-6 fatty acids and knee OA 22 omega-6 lipids (arachidonic acid, linoleic acid and 20 oxylipins)... Read More

The incidence, prevalence and survival of systemic sclerosis in the UK Clinical Practice Research Datalink (2018)
Journal Article
Royle, J. G., Lanyon, P. C., Grainge, M. J., Abhishek, A., & Pearce, F. A. (2018). The incidence, prevalence and survival of systemic sclerosis in the UK Clinical Practice Research Datalink. Clinical Rheumatology, 37(8), (2103–2111). ISSN 0770-3198

Objective: To estimate the incidence, prevalence and survival of systemic sclerosis in the United Kingdom. Methods: We conducted a historical cohort study using data from the Clinical Practice Research Datalink (CPRD). We calculated the incidence an... Read More

Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study (2018)
Journal Article
Abhishek, A., Courtney, P., Jenkins, W., Sandoval-Plata, G., Jones, A., Zhang, W., & Doherty, M. (2018). Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study. Arthritis and Rheumatology, 70(11), 1847-1852. doi:10.1002/art.40572

Objective To estimate the prevalence and distribution of asymptomatic monosodium urate (MSU) crystal deposition in sons of people with gout. Method People with gout were mailed an explanatory letter enclosing a postage-paid study-pack to mail to t... Read More

Barriers and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence (2017)
Journal Article
Kanavaki, A. M., Rushton, A., Efstathiou, N., Alrushud, A., Klocke, R., Abhishek, A., & Duda, J. L. (2017). Barriers and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence. BMJ Open, 7(12), doi:10.1136/bmjopen-2017-017042

Physical activity (PA), including engagement in structured exercise, has a key role in the management of hip and knee osteoarthritis (OA). However, maintaining a physically active lifestyle is a challenge for people with OA. PA determinants in this p... Read More

Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study (2017)
Journal Article
Kunze, G., Abhishek, A., Valdes, A. M., Jenkins, W., Zhang, W., & Doherty, M. (2017). Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study. PLoS ONE, 12(10), doi:10.1371/journal.pone.0186096. ISSN 1932-6203

Objectives To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute... Read More

Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study (2017)
Journal Article
Pearce, F. A., Hubbard, R., Grainge, M. J., Watts, R. A., Abhishek, A., & Lanyon, P. C. (in press). Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study. QJM: An International Journal of Medicine, doi:10.1093/qjmed/hcx194. ISSN 1460-2725

Background: People with granulomatosis with polyangiitis (GPA) commonly describe long delays before diagnosis. Aim: To study the natural history of GPA prior to diagnosis using primary care data, and determine whether clinical features could be iden... Read More

Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room? (2017)
Journal Article
Abhishek, A., & Doherty, M. (2017). Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room?. Arthritis Research and Therapy, 19, doi:10.1186/s13075-017-1394-x. ISSN 1478-6354

The first prospective population-based study to examine risk of erectile dysfunction in men with gout in the western world has been published. It reports that following their first diagnosis of gout, men have a 31% higher risk of erectile dysfunction... Read More

Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis (2017)
Journal Article
Valdes, A. M., Abhishek, A., Muir, K., Zhang, W., Maciewicz, R. A., & Doherty, M. (2017). Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis. Arthritis Care and Research, 69(7), doi:10.1002/acr.23091. ISSN 2151-464X

Objective: Recent findings suggest that β-adrenergic blockers have anti-nociceptive properties. The aim of this study was to compare levels of large joint pain between those on adrenergic blockers and those on other antihypertensive medications. Met... Read More

First validation of the gout activity score against gout impact scale in a primary care based gout cohort (2017)
Journal Article
La-Crette, J., Jenkins, W., Fernandes, G. S., Valdes, A. M., Doherty, M., & Abhishek, A. (in press). First validation of the gout activity score against gout impact scale in a primary care based gout cohort. Joint Bone Spine, doi:10.1016/j.jbspin.2017.05.010. ISSN 1297-319X

Objectives To validate the gout activity score (GAS) against the gout impact scale in a primary care based gout cohort. Methods This was a single-centre cross-sectional study. People with gout who participated in previous research at Academic Rheuma... Read More

Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study (2017)
Journal Article
Abhishek, A., Doherty, M., Kuo, C., Mallen, C. D., Zhang, W., & Grainge, M. J. (2017). Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study. Rheumatology, 56(5), doi:10.1093/rheumatology/kew468. ISSN 1462-0332

Objectives: The objectives of this study were to examine changes in incidence and prevalence of RA between 1990 and 2014, and to explore if there is any geographic variation in incidence and prevalence of RA in the UK Methods: Design Prospective... Read More